(data stored in SCRATCH zone)

SWISSPROT: C5B9B2_EDWI9

ID   C5B9B2_EDWI9            Unreviewed;       697 AA.
AC   C5B9B2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 67.
DE   SubName: Full=(P)ppGpp synthetase, RelA/SpoT family, putative {ECO:0000313|EMBL:ACR67292.1};
DE            EC=2.7.6.5 {ECO:0000313|EMBL:ACR67292.1};
GN   OrderedLocusNames=NT01EI_0032 {ECO:0000313|EMBL:ACR67292.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67292.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR67292.1, ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|EMBL:ACR67292.1,
RC   ECO:0000313|Proteomes:UP000001485};
RX   PubMed=22247535; DOI=10.1128/JB.06522-11;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA   Lawrence M.L.;
RT   "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated
RT   with a Natural Channel Catfish Outbreak of Enteric Septicemia of
RT   Catfish.";
RL   J. Bacteriol. 194:740-741(2012).
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5-'
CC       diphosphate) is a mediator of the stringent response that
CC       coordinates a variety of cellular activities in response to
CC       changes in nutritional abundance. {ECO:0000256|RuleBase:RU003847}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
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DR   EMBL; CP001600; ACR67292.1; -; Genomic_DNA.
DR   RefSeq; WP_015869516.1; NC_012779.2.
DR   EnsemblBacteria; ACR67292; ACR67292; NT01EI_0032.
DR   GeneID; 7959351; -.
DR   KEGG; eic:NT01EI_0032; -.
DR   PATRIC; fig|634503.3.peg.29; -.
DR   eggNOG; ENOG4105CWR; Bacteria.
DR   eggNOG; COG0317; LUCA.
DR   HOGENOM; HOG000018299; -.
DR   KO; K01139; -.
DR   OMA; HYYSIYQ; -.
DR   OrthoDB; 204079at2; -.
DR   BioCyc; EICT634503:G1GVC-28-MONOMER; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RelA_SpoT; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF81271; SSF81271; 1.
DR   TIGRFAMs; TIGR00691; spoT_relA; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5B9B2.
DR   SWISS-2DPAGE; C5B9B2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Transferase {ECO:0000313|EMBL:ACR67292.1}.
FT   DOMAIN       45    144       HD. {ECO:0000259|PROSITE:PS51831}.
FT   DOMAIN      623    697       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   697 AA;  78804 MW;  703B761BAA6EB22E CRC64;
     MYLFESLNLL IQKYLPEEQI KRLKQAYLVA RDAHEGQTRS SGEPYITHPV AVACILAEMR
     LDYETLMAAL LHDVIEDTPA TYQDMEQLFG KSVAELVEGV SKLDKLKFRD KKEAQAENFR
     KMIMAMVQDI RVILIKLADR THNMRTLGSL RPDKRRRIAR ETLEIYSPLA HRLGIHHLKT
     ELEELGFEAL YPNRYRVIKE VVKAARGNRK EMIQKILAEI DGRLSEAGMA CQVNGREKHL
     YSIYRKMHLK EQRFHSIMDI YAFRVIVKDV DTCYRVLGQA HSLYKPRPGR VKDYIAIPKA
     NGYQSLHTSL IGPHGVPVEV QIRTEDMDQM AEMGVAAHWA YKEGESSTTA QIRAQRWMQS
     LLELQQSAGN SFEFIESVKS DLFPDEIYVF TPEGRIVELP AGATPVDFAY AVHTDIGHAC
     VGARVDRQPY PLSQALSSGQ TIEVITAPGA RPNAAWLNFV VSSKARAKIR QMLKNLKRDD
     SVSLGRRLLN HALGNGRKLA SIPAPNIQRE LERMKLQSLD DLLAEIGLGN AMSVVVARNL
     LGEQDTPPGG RKLPIKGADG VLLTFAKCCR PIPGDPIIAH VSPGKGLVIH HESCRNIRGY
     QKEPEKFMPV EWDKDIDQEF IAEIKVDMFN HQGALANLTA AINATASNIQ SMNTEEKDGR
     VYSVYIRLTT RDRVHLANIM RKIRIMPDVI KVTRNRN
//

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