(data stored in SCRATCH zone)

SWISSPROT: C5BCF1_EDWI9

ID   C5BCF1_EDWI9            Unreviewed;       362 AA.
AC   C5BCF1;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 57.
DE   RecName: Full=Adenine DNA glycosylase {ECO:0000256|RuleBase:RU365096};
DE            EC=3.2.2.31 {ECO:0000256|RuleBase:RU365096};
GN   OrderedLocusNames=NT01EI_0272 {ECO:0000313|EMBL:ACR67514.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67514.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR67514.1, ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|EMBL:ACR67514.1,
RC   ECO:0000313|Proteomes:UP000001485};
RX   PubMed=22247535; DOI=10.1128/JB.06522-11;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA   Lawrence M.L.;
RT   "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated
RT   with a Natural Channel Catfish Outbreak of Enteric Septicemia of
RT   Catfish.";
RL   J. Bacteriol. 194:740-741(2012).
CC   -!- FUNCTION: Adenine glycosylase active on G-A mispairs.
CC       {ECO:0000256|RuleBase:RU365096}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8-
CC         oxoguanine:adenine mismatched double-stranded DNA, leaving an
CC         apurinic site.; EC=3.2.2.31;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|RuleBase:RU365096};
CC   -!- SIMILARITY: Belongs to the Nth/MutY family.
CC       {ECO:0000256|RuleBase:RU365096}.
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DR   EMBL; CP001600; ACR67514.1; -; Genomic_DNA.
DR   RefSeq; WP_015869723.1; NC_012779.2.
DR   EnsemblBacteria; ACR67514; ACR67514; NT01EI_0272.
DR   GeneID; 7960052; -.
DR   KEGG; eic:NT01EI_0272; -.
DR   PATRIC; fig|634503.3.peg.244; -.
DR   eggNOG; ENOG4105CEN; Bacteria.
DR   eggNOG; COG1194; LUCA.
DR   HOGENOM; HOG000028744; -.
DR   KO; K03575; -.
DR   OMA; RDPYRVW; -.
DR   OrthoDB; 1274533at2; -.
DR   BioCyc; EICT634503:G1GVC-251-MONOMER; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0019104; F:DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR   CDD; cd03431; DNA_Glycosylase_C; 1.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 1.10.1670.10; -; 1.
DR   InterPro; IPR005760; A/G_AdeGlyc_MutY.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR004036; Endonuclease-III-like_CS2.
DR   InterPro; IPR003651; Endonuclease3_FeS-loop_motif.
DR   InterPro; IPR004035; Endouclease-III_FeS-bd_BS.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR000445; HhH_motif.
DR   InterPro; IPR023170; HTH_base_excis_C.
DR   InterPro; IPR029119; MutY_C.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   Pfam; PF00633; HHH; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   Pfam; PF14815; NUDIX_4; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SMART; SM00525; FES; 1.
DR   SUPFAM; SSF48150; SSF48150; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   TIGRFAMs; TIGR01084; mutY; 1.
DR   PROSITE; PS00764; ENDONUCLEASE_III_1; 1.
DR   PROSITE; PS01155; ENDONUCLEASE_III_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BCF1.
DR   SWISS-2DPAGE; C5BCF1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   DNA damage {ECO:0000256|RuleBase:RU365096};
KW   Glycosidase {ECO:0000256|RuleBase:RU365096,
KW   ECO:0000313|EMBL:ACR67514.1};
KW   Hydrolase {ECO:0000313|EMBL:ACR67514.1};
KW   Iron {ECO:0000256|RuleBase:RU365096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485}.
FT   DOMAIN       40    191       ENDO3c. {ECO:0000259|SMART:SM00478}.
SQ   SEQUENCE   362 AA;  40480 MW;  2ED363E880178770 CRC64;
     MMQAQQFAHA VLAWYARFGR KTLPWQHPKT PYRVWLSEVM LQQTQVATVL PYFQRFTQRF
     PDVQTLASAP LDEVLHLWTG LGYYARARNL HKAAQLIVSR HHGEFPHDFE QVAALPGIGR
     STAGAILSLS LGQHHPILDG NVKRVLARCY AVPGWPGRKD VETRLWQLSG EVTPADGVSQ
     FNQAMMDLGA LVCTRSRPKC ELCPLNAGCL AYADGNWADF PGKKPRQTLP ERQAYLLLLQ
     HGETVWLQQR PASGLWGGLF CFPQYDSEAA LHTRLRHLGQ DPTAAQTLTA FRHTFSHFHL
     DIIPVWSTYT TASACMDEGD GLWYNLAQPP SVGLAAPTER LLQQLRRQPP ASAATGDATE
     KE
//

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