(data stored in SCRATCH zone)

SWISSPROT: C5BFA8_EDWI9

ID   C5BFA8_EDWI9            Unreviewed;       158 AA.
AC   C5BFA8;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 62.
DE   RecName: Full=Transcription elongation factor GreA {ECO:0000256|HAMAP-Rule:MF_00105, ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS00033968};
DE   AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   Name=greA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   OrderedLocusNames=NT01EI_0456 {ECO:0000313|EMBL:ACR67694.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67694.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting
CC       sites in DNA have the property of trapping a certain fraction of
CC       elongating RNA polymerases that pass through, resulting in locked
CC       ternary complexes. Cleavage of the nascent transcript by cleavage
CC       factors such as GreA or GreB allows the resumption of elongation
CC       from the new 3'terminus. GreA releases sequences of 2 to 3
CC       nucleotides. {ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS00003943}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00105, ECO:0000256|RuleBase:RU000556,
CC       ECO:0000256|SAAS:SAAS00541981}.
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DR   EMBL; CP001600; ACR67694.1; -; Genomic_DNA.
DR   RefSeq; WP_015869896.1; NC_012779.2.
DR   STRING; 634503.NT01EI_0456; -.
DR   EnsemblBacteria; ACR67694; ACR67694; NT01EI_0456.
DR   GeneID; 7961281; -.
DR   KEGG; eic:NT01EI_0456; -.
DR   PATRIC; fig|634503.3.peg.415; -.
DR   eggNOG; ENOG4108UKH; Bacteria.
DR   eggNOG; COG0782; LUCA.
DR   HOGENOM; HOG000241145; -.
DR   KO; K03624; -.
DR   OMA; TWLTQEA; -.
DR   OrthoDB; POG091H00BT; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.30; -; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF46557; SSF46557; 1.
DR   TIGRFAMs; TIGR01462; greA; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
DR   PROSITE; PS00830; GREAB_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BFA8.
DR   SWISS-2DPAGE; C5BFA8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS00003957};
KW   Elongation factor {ECO:0000313|EMBL:ACR67694.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:ACR67694.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS00018751};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS00018712}.
FT   DOMAIN        4     74       GreA_GreB_N. {ECO:0000259|Pfam:PF03449}.
FT   DOMAIN       83    157       GreA_GreB. {ECO:0000259|Pfam:PF01272}.
SQ   SEQUENCE   158 AA;  17668 MW;  A311612C7AA8BA3C CRC64;
     MNQIPMTLRG AEKLREELDF LKGTRRPQII AAIAEAREHG DLKENAEYHA AREQQGFCEG
     RIQEIEAKLS NAQVIDVTKM PNNGRVIFGS TVSVENLNTE DQQTYRIVGD DEADFKHNLI
     SVNSPIARGL IGKEEGDVVT IKTPGGEVEY EILNVEYL
//

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