(data stored in SCRATCH zone)

SWISSPROT: C5BFB6_EDWI9

ID   C5BFB6_EDWI9            Unreviewed;       495 AA.
AC   C5BFB6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 75.
DE   RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   OrderedLocusNames=NT01EI_0466 {ECO:0000313|EMBL:ACR67702.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67702.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR67702.1, ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|EMBL:ACR67702.1,
RC   ECO:0000313|Proteomes:UP000001485};
RX   PubMed=22247535; DOI=10.1128/JB.06522-11;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA   Lawrence M.L.;
RT   "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated
RT   with a Natural Channel Catfish Outbreak of Enteric Septicemia of
RT   Catfish.";
RL   J. Bacteriol. 194:740-741(2012).
CC   -!- FUNCTION: Participates in both transcription termination and
CC       antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC       dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
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DR   EMBL; CP001600; ACR67702.1; -; Genomic_DNA.
DR   RefSeq; WP_015869904.1; NC_012779.2.
DR   EnsemblBacteria; ACR67702; ACR67702; NT01EI_0466.
DR   GeneID; 7961289; -.
DR   KEGG; eic:NT01EI_0466; -.
DR   PATRIC; fig|634503.3.peg.423; -.
DR   eggNOG; ENOG4105CHV; Bacteria.
DR   eggNOG; COG0195; LUCA.
DR   HOGENOM; HOG000006394; -.
DR   KO; K02600; -.
DR   OMA; SRTTPKM; -.
DR   OrthoDB; 384865at2; -.
DR   BioCyc; EICT634503:G1GVC-436-MONOMER; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1480.10; -; 1.
DR   Gene3D; 3.30.300.20; -; 2.
DR   HAMAP; MF_00945_B; NusA_B; 1.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR025249; KH_dom_NusA-like.
DR   InterPro; IPR009019; KH_sf_prok-type.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR030842; NusA_bac.
DR   InterPro; IPR036555; NusA_N_sf.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR013735; TF_NusA_N.
DR   InterPro; IPR010214; Tscrpt_termin_fac_NusA_C_rpt.
DR   InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR   PANTHER; PTHR22648; PTHR22648; 1.
DR   Pfam; PF13184; KH_5; 1.
DR   Pfam; PF08529; NusA_N; 1.
DR   SMART; SM00322; KH; 2.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF47794; SSF47794; 2.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF54814; SSF54814; 2.
DR   SUPFAM; SSF69705; SSF69705; 1.
DR   TIGRFAMs; TIGR01953; NusA; 1.
DR   TIGRFAMs; TIGR01954; nusA_Cterm_rpt; 2.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BFB6.
DR   SWISS-2DPAGE; C5BFB6.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Elongation factor {ECO:0000313|EMBL:ACR67702.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:ACR67702.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_00945};
KW   RNA-binding {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription antitermination {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription termination {ECO:0000256|HAMAP-Rule:MF_00945}.
FT   DOMAIN      135    200       S1 motif. {ECO:0000259|PROSITE:PS50126}.
FT   COILED      403    423       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   495 AA;  54732 MW;  31EE8FC3656B29DA CRC64;
     MNKEILAVVE AVSNEKALPR EKIFEALETA LATATKKKYE QEIDVRVAID RKSGDFDTFR
     RWLIVEEVTQ PTREITLDAA RFEDPALDLG DYVEDQIESV TFDRITTQTA KQVIVQKVRE
     AERAMVVDAF REHEGEIVTG VVKKVNRDSI SLDLGNNAEA VIGREDMLPR ENFRPGDRIR
     GVLYAVRPEA RGAQLFVTRS RPEMLIELFR IEVPEIGEEV IEIKGAARDP GSRAKIAVKT
     NDKRIDPVGA CVGMRGARVQ AVSSELGGER IDIVLWDDNP AQFVINAMAP ADVASIVVDE
     DKHTMDIAVE ASNLAQAIGR NGQNVRLASQ LSGWELNVMT AEDLQAKHQA EAHAAIDTFT
     KHLDIDEEFA TLLVEEGFSS LEELAYVPER ELLSIDGLDE DTVEVLRTRA KNALTTLALA
     QEESLGDNKP ADDLLNLPGM ERSVAFKLAA RGVCTLEDLA EQGVDDLTDI EGLNNEQAGE
     LIMAARNICW FGDSE
//

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