(data stored in SCRATCH zone)

SWISSPROT: C5BH35_EDWI9

ID   C5BH35_EDWI9            Unreviewed;       494 AA.
AC   C5BH35;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 73.
DE   RecName: Full=Sodium/proline symporter {ECO:0000256|RuleBase:RU366012};
DE   AltName: Full=Proline permease {ECO:0000256|RuleBase:RU366012};
GN   OrderedLocusNames=NT01EI_0483 {ECO:0000313|EMBL:ACR67718.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67718.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR67718.1, ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|EMBL:ACR67718.1,
RC   ECO:0000313|Proteomes:UP000001485};
RX   PubMed=22247535; DOI=10.1128/JB.06522-11;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA   Lawrence M.L.;
RT   "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated
RT   with a Natural Channel Catfish Outbreak of Enteric Septicemia of
RT   Catfish.";
RL   J. Bacteriol. 194:740-741(2012).
CC   -!- FUNCTION: Catalyzes the sodium-dependent uptake of extracellular
CC       L-proline. {ECO:0000256|RuleBase:RU366012}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU366012}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366012}.
CC   -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF)
CC       (TC 2.A.21) family. {ECO:0000256|RuleBase:RU366012}.
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DR   EMBL; CP001600; ACR67718.1; -; Genomic_DNA.
DR   RefSeq; WP_015869919.1; NC_012779.2.
DR   EnsemblBacteria; ACR67718; ACR67718; NT01EI_0483.
DR   GeneID; 7961510; -.
DR   KEGG; eic:NT01EI_0483; -.
DR   PATRIC; fig|634503.3.peg.437; -.
DR   eggNOG; ENOG4105CK7; Bacteria.
DR   eggNOG; COG0591; LUCA.
DR   HOGENOM; HOG000282935; -.
DR   KO; K11928; -.
DR   OMA; YARYHKC; -.
DR   OrthoDB; 231452at2; -.
DR   BioCyc; EICT634503:G1GVC-450-MONOMER; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005298; F:proline:sodium symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031402; F:sodium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015824; P:proline transport; IEA:UniProtKB-UniRule.
DR   CDD; cd11475; SLC5sbd_PutP; 1.
DR   Gene3D; 1.20.1730.10; -; 1.
DR   InterPro; IPR038377; Na/Glc_symporter_sf.
DR   InterPro; IPR011851; Na/Pro_symporter.
DR   InterPro; IPR001734; Na/solute_symporter.
DR   InterPro; IPR018212; Na/solute_symporter_CS.
DR   Pfam; PF00474; SSF; 1.
DR   TIGRFAMs; TIGR02121; Na_Pro_sym; 1.
DR   TIGRFAMs; TIGR00813; sss; 1.
DR   PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR   PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BH35.
DR   SWISS-2DPAGE; C5BH35.
KW   Amino-acid transport {ECO:0000256|RuleBase:RU366012};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU366012};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00735906};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Ion transport {ECO:0000256|RuleBase:RU366012};
KW   Membrane {ECO:0000256|RuleBase:RU366012};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Sodium {ECO:0000256|RuleBase:RU366012};
KW   Sodium transport {ECO:0000256|RuleBase:RU366012};
KW   Symport {ECO:0000256|RuleBase:RU366012};
KW   Transmembrane {ECO:0000256|RuleBase:RU366012};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU366012};
KW   Transport {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM     67     88       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    127    152       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    164    185       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    192    212       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    232    255       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    275    296       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    325    350       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    371    391       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    403    422       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    429    449       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    455    473       Helical. {ECO:0000256|RuleBase:RU366012}.
SQ   SEQUENCE   494 AA;  53731 MW;  BE688EC204FC2F79 CRC64;
     MSVNTPTLIT FLIYIFGMIL IGLLAYRATN NFSDYILGGR RLGSVVTALS AGASDMSGWL
     LMGLPGAIFV AGLSESWIAI GLVLGAYLNW RIVAGRLRVH TELNNNALTL PDYFTQRFED
     KQHILRLISA LIILVFFTVY CASGVVAGAR LFESTFGMSY ESALWAGAAA TIAYTFIGGF
     LAISWTDTVQ ATLMIFALIL TPVMVVVSVG GFDDAINAIA QRSPAYLDLF RGLDWVAIVS
     LMGWGLGYCG QPHILARFMA ADSHHTIRKA RRISIVWMIF CLGGAVAVGF FGIAFFSTHP
     QLALEVHENK ERVFISLAKL LFNPWIAGVL LSAILAAVMS TLSCQLLVSA SAVTEDLYKA
     FLRKHANQRE LVIVSRTMVM LIALIAIGLA ANPHNYVLDL VSYAWAGFGA AFGPVIIISL
     LWPGMTRNGA LAGMLVGAAT VVVWKQYAWF HLYEIIPGFI LASLAIVLVS LVGRGPSPQM
     RERFAQANKI YLTK
//

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