(data stored in SCRATCH zone)

SWISSPROT: C5BHE9_EDWI9

ID   C5BHE9_EDWI9            Unreviewed;       228 AA.
AC   C5BHE9;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 47.
DE   RecName: Full=Endonuclease V {ECO:0000256|HAMAP-Rule:MF_00801};
DE            EC=3.1.21.7 {ECO:0000256|HAMAP-Rule:MF_00801};
DE   AltName: Full=Deoxyinosine 3'endonuclease {ECO:0000256|HAMAP-Rule:MF_00801};
DE   AltName: Full=Deoxyribonuclease V {ECO:0000256|HAMAP-Rule:MF_00801};
DE            Short=DNase V {ECO:0000256|HAMAP-Rule:MF_00801};
GN   Name=nfi {ECO:0000256|HAMAP-Rule:MF_00801};
GN   OrderedLocusNames=NT01EI_0181 {ECO:0000313|EMBL:ACR67427.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67427.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA repair enzyme involved in the repair of deaminated
CC       bases. Selectively cleaves double-stranded DNA at the second
CC       phosphodiester bond 3' to a deoxyinosine leaving behind the intact
CC       lesion on the nicked DNA. {ECO:0000256|HAMAP-Rule:MF_00801}.
CC   -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
CC       apyrimidinic sites to products with a 5'-phosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_00801}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00801};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00801}.
CC   -!- SIMILARITY: Belongs to the endonuclease V family.
CC       {ECO:0000256|HAMAP-Rule:MF_00801}.
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DR   EMBL; CP001600; ACR67427.1; -; Genomic_DNA.
DR   RefSeq; WP_015869639.1; NC_012779.2.
DR   ProteinModelPortal; C5BHE9; -.
DR   STRING; 634503.NT01EI_0181; -.
DR   EnsemblBacteria; ACR67427; ACR67427; NT01EI_0181.
DR   GeneID; 7958772; -.
DR   KEGG; eic:NT01EI_0181; -.
DR   PATRIC; fig|634503.3.peg.163; -.
DR   eggNOG; ENOG4105Y7X; Bacteria.
DR   eggNOG; COG1515; LUCA.
DR   HOGENOM; HOG000229135; -.
DR   KO; K05982; -.
DR   OMA; GYKLPEP; -.
DR   OrthoDB; POG091H0CQB; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043737; F:deoxyribonuclease V activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-HAMAP.
DR   CDD; cd06559; Endonuclease_V; 1.
DR   HAMAP; MF_00801; Endonuclease_5; 1.
DR   InterPro; IPR007581; Endonuclease-V.
DR   PANTHER; PTHR28511; PTHR28511; 1.
DR   Pfam; PF04493; Endonuclease_5; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BHE9.
DR   SWISS-2DPAGE; C5BHE9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00801};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00801};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00801};
KW   Endonuclease {ECO:0000256|HAMAP-Rule:MF_00801,
KW   ECO:0000313|EMBL:ACR67427.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00801,
KW   ECO:0000313|EMBL:ACR67427.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00801};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00801};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485}.
FT   METAL        33     33       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_00801}.
FT   METAL       101    101       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_00801}.
FT   SITE         71     71       Interaction with target DNA.
FT                                {ECO:0000256|HAMAP-Rule:MF_00801}.
SQ   SEQUENCE   228 AA;  25365 MW;  F0DD61636E494BE4 CRC64;
     MDLPALRSEQ RARAVQVEQV DRWETPAFIA GADVGFEQDG LVTRAALAVL RYPELTLVEY
     QVARIETQMP YIPGFLSFRE YPALLQAWGL LQHRPQLVMV DGHGIAHPRR LGIASHFGLL
     ADVPTIGIAK RRLCGQSAPL DETPGSAVAL MDGTEQLGWV LRSKARCHPL FISGGHRVST
     DSALTWVQRC LRGYRLPEPT RWADAIASRR PAFLRWQAAQ PRSAIALE
//

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