(data stored in ACNUC1104 zone)

SWISSPROT: C5C3L9_BEUC1

ID   C5C3L9_BEUC1            Unreviewed;       546 AA.
AC   C5C3L9;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   10-APR-2019, entry version 52.
DE   SubName: Full=Drug resistance transporter, EmrB/QacA subfamily {ECO:0000313|EMBL:ACQ81928.1};
GN   OrderedLocusNames=Bcav_3686 {ECO:0000313|EMBL:ACQ81928.1};
OS   Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC   Bacteria; Actinobacteria; Micrococcales; Beutenbergiaceae;
OC   Beutenbergia.
OX   NCBI_TaxID=471853 {ECO:0000313|EMBL:ACQ81928.1, ECO:0000313|Proteomes:UP000007962};
RN   [1] {ECO:0000313|EMBL:ACQ81928.1, ECO:0000313|Proteomes:UP000007962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432
RC   {ECO:0000313|Proteomes:UP000007962};
RX   PubMed=21304633; DOI=10.4056/sigs.1162;
RA   Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA   Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M.,
RA   Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavromatis K.,
RA   Ovchinnikova G., Pati A., Chen A., Palaniappan K., Hauser L.,
RA   Chang Y.J., Jefferies C.C., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Chain P., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT   0122).";
RL   Stand. Genomic Sci. 1:21-28(2009).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP001618; ACQ81928.1; -; Genomic_DNA.
DR   RefSeq; WP_015884165.1; NC_012669.1.
DR   EnsemblBacteria; ACQ81928; ACQ81928; Bcav_3686.
DR   KEGG; bcv:Bcav_3686; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; SWLCGIS; -.
DR   OrthoDB; 1108236at2; -.
DR   BioCyc; BCAV471853:G1GET-3745-MONOMER; -.
DR   Proteomes; UP000007962; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5C3L9.
DR   SWISS-2DPAGE; C5C3L9.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007962};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007962};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     31     49       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     61     81       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     93    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    151    169       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    181    201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    213    231       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    251    272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    293    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    357    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    383    405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    519    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    542       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   546 AA;  56158 MW;  8E1EB6E5761F03BD CRC64;
     MSTTTTAPGS PAPGGAVDLH GRSPWSVIPP LALGFFMIMV DTTIVNIAVP TLTAELDADL
     VSIGWVNSAY LLSYAVLLLL AGRLGDRYGP KPVFVLGLVV FTAASAWCGL AGTVEMLIVA
     RVVQGIGAAL MTPQTMSMIT RVFPPRGRGA AMGLWGAVAG VATITGPVLG GFLVETWGWE
     WIFFVNIPVG VIALVMAFTN LPRLATHKRS FDLLGVALSI IGLFAFVFGL QEGETYDWGR
     IGVVSVGPVD VPVTVVGLIV VGLLVLTGFV LWQHHLRDRA LLPLSLFSHR NFSLANVGGM
     AVSFAMIGIF FPLTIYLQTI LDLSPLHAAL LNLPGSLVSG VVAPIAGRLS DRIPGKWVVA
     AGFAAIAGAV VWLWAIVSPD TSPLAFLAPM ALFGVGTGAV FSPLANLATS GLDHRTAGAG
     AGAFNTTRQV GGVIGSAAIV AMLTARLSVT LPAAARDAAA GLPAELREPF VEGFSQAGGS
     FGGTMPALPP GIPDDVAQLL QDAATSAFHS GFATATGQTL LLAAGVLVVG MLAALAMDRG
     HHGGQP
//

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