(data stored in SCRATCH zone)

SWISSPROT: C5DC89_LACTC

ID   C5DC89_LACTC            Unreviewed;      1015 AA.
AC   C5DC89;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   11-DEC-2019, entry version 62.
DE   SubName: Full=KLTH0B01078p {ECO:0000313|EMBL:CAR21400.1};
GN   OrderedLocusNames=KLTH0B01078g {ECO:0000313|EMBL:CAR21400.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21400.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21400.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC       {ECO:0000256|RuleBase:RU000519}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU928166; CAR21400.1; -; Genomic_DNA.
DR   RefSeq; XP_002551838.1; XM_002551792.1.
DR   STRING; 381046.XP_002551838.1; -.
DR   EnsemblFungi; CAR21400; CAR21400; KLTH0B01078g.
DR   GeneID; 8290664; -.
DR   KEGG; lth:KLTH0B01078g; -.
DR   HOGENOM; HOG000167329; -.
DR   InParanoid; C5DC89; -.
DR   KO; K03178; -.
DR   OMA; CIVWARL; -.
DR   OrthoDB; 91748at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0006464; P:cellular protein modification process; IEA:InterPro.
DR   Gene3D; 1.10.10.2660; -; 1.
DR   Gene3D; 2.40.30.180; -; 1.
DR   Gene3D; 3.10.290.60; -; 1.
DR   Gene3D; 3.50.50.80; -; 1.
DR   InterPro; IPR032420; E1_4HB.
DR   InterPro; IPR032418; E1_FCCH.
DR   InterPro; IPR042302; E1_FCCH_sf.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR018965; Ub-activating_enz_E1_C.
DR   InterPro; IPR042449; Ub-E1_IAD_1.
DR   InterPro; IPR038252; UBA_E1_C_sf.
DR   InterPro; IPR019572; UBA_E1_Cys.
DR   InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   InterPro; IPR018075; UBQ-activ_enz_E1.
DR   InterPro; IPR018074; UBQ-activ_enz_E1_CS.
DR   InterPro; IPR033127; UBQ-activ_enz_E1_Cys_AS.
DR   InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR   Pfam; PF16191; E1_4HB; 1.
DR   Pfam; PF16190; E1_FCCH; 1.
DR   Pfam; PF09358; E1_UFD; 1.
DR   Pfam; PF00899; ThiF; 2.
DR   Pfam; PF10585; UBA_e1_thiolCys; 1.
DR   PRINTS; PR01849; UBIQUITINACT.
DR   SMART; SM00985; UBA_e1_C; 1.
DR   SUPFAM; SSF69572; SSF69572; 2.
DR   TIGRFAMs; TIGR01408; Ube1; 1.
DR   PROSITE; PS00536; UBIQUITIN_ACTIVAT_1; 1.
DR   PROSITE; PS00865; UBIQUITIN_ACTIVAT_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DC89.
DR   SWISS-2DPAGE; C5DC89.
KW   ATP-binding {ECO:0000256|RuleBase:RU000519};
KW   Ligase {ECO:0000256|RuleBase:RU000519};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000519};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Ubl conjugation pathway {ECO:0000256|RuleBase:RU000519}.
FT   DOMAIN          885..1011
FT                   /note="UBA_e1_C"
FT                   /evidence="ECO:0000259|SMART:SM00985"
FT   REGION          768..787
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        593
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10132"
SQ   SEQUENCE   1015 AA;  113042 MW;  16ABB8A4A4689C39 CRC64;
     MVKPGEIDES LYSRQLYVLG KEAMLKMQHS TVLIIGLKGL GVEIAKNIAL AGVKSLTLFD
     PAPVVLEDLS TQFFLSEKDV GKPRAAVSQA KLAELNSYVP IDVLDSLQDQ EQLKKYQVIV
     ATETLPLERK IELNNFCHAA GIKFIATETR GLFGSVFNDF GEEFTVVDPT GEEPQSGIVS
     DIEPDGTVTM LDDNRHNLED GNYVKFSEVE GLEKLNDGTP YKVEVLGPFA FRIGSVKELG
     TYKKGGVFTQ VKMPLKLSFK TLQQSLPNPE HLYSDFAKFE RPGQLHLGFQ ALDQFQATHQ
     GQLPRPFNEE DANELIELTS KLAVQQPKVL GEGNSVNKDI IRELSFQARG DIPGMVAFFG
     GLVAQEALKA CSGKFTPLKQ YMYFDSLESL PDAKEYPRNE ETTRSINSRY DPQIAVFGLE
     FQRKLANSKV FLVGSGAIGC EMLKNWALLG LGSGPDGKIF ITDNDSIEKS NLNRQFLFRP
     KDVGRNKSEV ASEAVSNMNP DLQGKIKWMT EKVGAESEDL FNDDFWNGLD FVTNALDNVD
     ARTYVDRKCV FYKKPLLESG TLGTKGNTQV VIPNVTESYS SSRDPPEKSI PLCTLRSFPN
     KIDHTIAWAK SLFQGYFTEA PENVNLYLTQ PDFVQQTLKQ AGDVKGILES IADSLNNRPY
     DFDDCIKWAR LEFEKKFNHE IQQLLYNFPK DSKTSTGAPF WSGPKRAPEP LVFDIKNPDH
     FYFVVGAANL RAFNYGLTGD EGEPDISHYE SVLANTNVPA FSPRSDVKIQ ANDDEPDPNS
     NSDVGGDALE ALTASLPDPS TLAGFKLLPA EFEKDDDSNH HIEFITSASN DRALNYSIET
     ADRQKTKFIA GRIIPAIATT TGLVTGLVNL ELYKVVDGKT DIEAYQNGFI NLALPFFGFS
     DPIASPQGKY NDKSYDKIWD RFDIRGNITL KELIDHFDEK EGLEITMLSY GVSLLYASFF
     PPKKLKDRLN LPITEVVKLV TKNEVAPHVK TMILEICADD KNGEDVEVPY ITIHL
//

If you have problems or comments...

PBIL Back to PBIL home page