(data stored in SCRATCH zone)

SWISSPROT: C5DCG2_LACTC

ID   C5DCG2_LACTC            Unreviewed;       470 AA.
AC   C5DCG2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 62.
DE   RecName: Full=General transcription and DNA repair factor IIH {ECO:0000256|PIRNR:PIRNR015919};
GN   OrderedLocusNames=KLTH0B02794g {ECO:0000313|EMBL:CAR21473.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21473.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21473.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Component of the general transcription and DNA repair
CC       factor IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged
CC       DNA and, when complexed to TFIIK, in RNA transcription by RNA
CC       polymerase II. {ECO:0000256|PIRNR:PIRNR015919}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR015919}.
CC   -!- SIMILARITY: Belongs to the GTF2H2 family.
CC       {ECO:0000256|PIRNR:PIRNR015919}.
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DR   EMBL; CU928166; CAR21473.1; -; Genomic_DNA.
DR   RefSeq; XP_002551911.1; XM_002551865.1.
DR   STRING; 381046.XP_002551911.1; -.
DR   EnsemblFungi; CAR21473; CAR21473; KLTH0B02794g.
DR   GeneID; 8290742; -.
DR   KEGG; lth:KLTH0B02794g; -.
DR   HOGENOM; HOG000159415; -.
DR   InParanoid; C5DCG2; -.
DR   KO; K03142; -.
DR   OMA; IRMGFPH; -.
DR   OrthoDB; 768809at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:InterPro.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01453; vWA_transcription_factor_IIH_t; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR007198; Ssl1-like.
DR   InterPro; IPR004595; TFIIH_C1-like_dom.
DR   InterPro; IPR012170; TFIIH_SSL1/p44.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF07975; C1_4; 1.
DR   Pfam; PF04056; Ssl1; 1.
DR   PIRSF; PIRSF015919; TFIIH_SSL1; 1.
DR   SMART; SM01047; C1_4; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   TIGRFAMs; TIGR00622; ssl1; 1.
DR   PROSITE; PS50234; VWFA; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCG2.
DR   SWISS-2DPAGE; C5DCG2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR015919};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR015919};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Transcription {ECO:0000256|PIRNR:PIRNR015919};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR015919};
KW   Zinc {ECO:0000256|PIRNR:PIRNR015919}.
FT   DOMAIN      134    314       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   ZN_FING     358    375       C4-type. {ECO:0000256|PIRSR:PIRSR015919-
FT                                1}.
SQ   SEQUENCE   470 AA;  53027 MW;  39817454B9DC75BE CRC64;
     MAPIVESDSE DESLNRPKKQ VRGRTSKGKK HVRIEEDYNE DGHSMSEDDE NLFSEDEADS
     GPSNGRKKKK LANKNLQGAN GGYAWEEDIQ RSWDLVKVDD EGNMAALVSS IIEARKKRAS
     NKNLTPFQRG IIRTMVLVLD CSDAMMEKDL RPNRYAMTIQ YAINFVHEFF DQNPISQIGI
     VCMRNDLAQL VSQVSGNPQD HIDALKAIRK QEPKGNSSLQ NALEMARGLL LHVPAHCTRE
     VLIIFGALSS TDPGDIHQTI ASLVQERIRV RVIGLSAQVA ICKELCKQTN YGDNSFYGVI
     LNEVHFKDLF AEAVTPLPVN KINKGFTLVK MGFPTRVYED MPSFCTCHSK LMYGGYFCPN
     CKSKVCSLPT VCPCCDLMLI LSTHLARSYH HLMPLKTFQE VDVAETFPTD TCYSCQKRFP
     RLKNQKTQEL LTSSRYRCAD CHQDFCIDCD VFIHEILHNC PGCESQPGIW
//

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