(data stored in SCRATCH zone)

SWISSPROT: C5DCH3_LACTC

ID   C5DCH3_LACTC            Unreviewed;       427 AA.
AC   C5DCH3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   11-DEC-2019, entry version 51.
DE   RecName: Full=Histone acetyltransferase {ECO:0000256|PROSITE-ProRule:PRU01064};
DE            EC=2.3.1.48 {ECO:0000256|PROSITE-ProRule:PRU01064};
GN   OrderedLocusNames=KLTH0B03080g {ECO:0000313|EMBL:CAR21484.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21484.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21484.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC         lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC         Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01064};
CC   -!- SIMILARITY: Belongs to the RTT109 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01064}.
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DR   EMBL; CU928166; CAR21484.1; -; Genomic_DNA.
DR   RefSeq; XP_002551922.1; XM_002551876.1.
DR   STRING; 381046.XP_002551922.1; -.
DR   EnsemblFungi; CAR21484; CAR21484; KLTH0B03080g.
DR   GeneID; 8290755; -.
DR   KEGG; lth:KLTH0B03080g; -.
DR   HOGENOM; HOG000001105; -.
DR   InParanoid; C5DCH3; -.
DR   KO; K11309; -.
DR   OMA; ADTNGYC; -.
DR   OrthoDB; 594915at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0010484; F:H3 histone acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; IEA:InterPro.
DR   InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
DR   InterPro; IPR016849; Rtt109.
DR   PANTHER; PTHR31571:SF2; PTHR31571:SF2; 1.
DR   Pfam; PF08214; HAT_KAT11; 1.
DR   SMART; SM01250; KAT11; 1.
DR   PROSITE; PS51728; RTT109_HAT; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCH3.
DR   SWISS-2DPAGE; C5DCH3.
KW   DNA damage {ECO:0000256|PROSITE-ProRule:PRU01064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   REGION          393..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  48507 MW;  B5D325A1ED415D52 CRC64;
     MSSLENLLSR VLPENKKFEL LHLQSPPKES HSVFVQQRSD CTQTVVKVQH FFGLGADEKI
     FYSLELFVYL TIESSKAIEK LIFVSKADTN GYCDEKISVK DITTAILDYI VTLDPSHYLS
     KEIKVSGTSP GCGPSITRCT TTKRALKILK ARHDSKKGDN CPNRGFFRNI EGKDPDWTCK
     ICLFTRSEPQ YLFSESSRNP KKHILSGEQL LRWWLSVIDK ILVRHFDSGT KATLQIPGEE
     ESRTLRYLSN NKAPFWRVGD IFSGKSSELA IFAIPVFPDD PKGRFLEQVV EENRAKKVRL
     SDFWVELQVQ QEFRLGCTVS VIGVDGRIPK KCFGPHNNEV IVMPSKKVFS IVKSYIVGEQ
     YDTSEGAYEA YANLRDFLHL RMQRSLLEIR GCRKSSEPGS KGTGSDRNAP VRPLNTLTVR
     RKVKKSI
//

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