(data stored in SCRATCH zone)

SWISSPROT: C5DCM3_LACTC

ID   C5DCM3_LACTC            Unreviewed;       866 AA.
AC   C5DCM3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   11-DEC-2019, entry version 49.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=KLTH0B04268g {ECO:0000313|EMBL:CAR21534.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21534.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21534.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU928166; CAR21534.1; -; Genomic_DNA.
DR   RefSeq; XP_002551972.1; XM_002551926.1.
DR   STRING; 381046.XP_002551972.1; -.
DR   EnsemblFungi; CAR21534; CAR21534; KLTH0B04268g.
DR   GeneID; 8290809; -.
DR   KEGG; lth:KLTH0B04268g; -.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; C5DCM3; -.
DR   KO; K02154; -.
DR   OMA; VKFCPFS; -.
DR   OrthoDB; 181796at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCM3.
DR   SWISS-2DPAGE; C5DCM3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        456..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        500..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        578..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        607..631
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        672..690
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        773..793
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        805..828
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          115..149
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          315..335
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   866 AA;  98665 MW;  B1DFE79F06EB06EF CRC64;
     MTREEAIFRS ADMTYVQLYI PLELSREVVC LLGNMGNVMF RDLNTDLTTF QRGYVNQIRK
     FDDLERLIDY MSNVASRYSE ATWKYVFHGD NDNATQHPSM NFLMSSMHTH SLDTVSDLTA
     EITEFESRVR QLDESLVNLR KRLNTLIEHR HAAFECGRYM EVNPGLRGRA ARSQQHRDLE
     QLTVEDFRLS DDEVSETLSD TFSFDEVSED NSVPSAGRDL SAELEEGFRH RTTIIGSINR
     SKVETLNKIL WRILRGNLFF HNIPIEEPLL EKGELVQKDC FVVFTHGDVL LKKVKRVVES
     LNGTIFPGNE GRSTIKNLNT QIADLQQICQ TTEQTLHTEL LIVSDQLPMW RAVARREKLI
     YAALNLFRQE SQGLVAEGWL PSTELLIVSN ALKNHSENIG SENSAVVSVI KTSKKPPTYH
     RTNKFTQSFQ AIVDAYGIAT YKEVNPGLAT IVTFPFMFAI MFGDTGHGAI VFLIALFLVL
     NEKKLAQAQN GEIFDMAFSG RYVILLMGFF SIYTGLLYND IFSLSMTFFK SGWKWNSGFK
     EGEAIEATNT GVYPFGLDYA WHGTENNLIF SNSYKMKLSI LMGFIHMTYS LFFSLVNYRY
     FRSRVDIIGN FIPGFIFMQS IFGYLSWAII YKWSKDWIKD GKVAPGLLNM LINMFLAPGV
     VDEPLFRGQS YLQVFLLLCA LICVPWLLLY KPLKLRAQNK AAISNGYQNI HDQNASESLL
     ESQEDAGGEI LVTDYDENHS NTFEFGDIMI HQVIHTIEFC LNCISHTASY LRLWALSLAH
     AQLSSVLWTM TIANAFSSKD SGSPLAVIKV VFLFGMWFVL TVCILVLMEG TSAMLHSLRL
     HWVEAMSKFF EGDGYPYEPF SFKALD
//

If you have problems or comments...

PBIL Back to PBIL home page