(data stored in SCRATCH zone)

SWISSPROT: C5DCQ5_LACTC

ID   C5DCQ5_LACTC            Unreviewed;       740 AA.
AC   C5DCQ5;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 56.
DE   RecName: Full=Histone acetyltransferase {ECO:0000256|RuleBase:RU361211};
DE            EC=2.3.1.48 {ECO:0000256|RuleBase:RU361211};
GN   OrderedLocusNames=KLTH0B04994g {ECO:0000313|EMBL:CAR21566.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21566.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21566.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-
CC         acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-
CC         COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:61930; EC=2.3.1.48;
CC         Evidence={ECO:0000256|RuleBase:RU361211};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU361211}.
CC   -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC       {ECO:0000256|RuleBase:RU361211}.
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DR   EMBL; CU928166; CAR21566.1; -; Genomic_DNA.
DR   RefSeq; XP_002552004.1; XM_002551958.1.
DR   STRING; 381046.XP_002552004.1; -.
DR   EnsemblFungi; CAR21566; CAR21566; KLTH0B04994g.
DR   GeneID; 8290842; -.
DR   KEGG; lth:KLTH0B04994g; -.
DR   HOGENOM; HOG000141817; -.
DR   InParanoid; C5DCQ5; -.
DR   KO; K11378; -.
DR   OMA; RENVIYC; -.
DR   OrthoDB; 629545at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR037995; Esa1/KAT5/Tip60.
DR   InterPro; IPR002717; HAT_MYST-type.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR040706; Zf-MYST.
DR   PANTHER; PTHR10615:SF161; PTHR10615:SF161; 1.
DR   Pfam; PF01853; MOZ_SAS; 1.
DR   Pfam; PF17772; zf-MYST; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51726; MYST_HAT; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCQ5.
DR   SWISS-2DPAGE; C5DCQ5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Nucleus {ECO:0000256|RuleBase:RU361211};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   DOMAIN      213    506       MYST-type HAT. {ECO:0000259|PROSITE:
FT                                PS51726}.
FT   ACT_SITE    393    393       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR602717-51}.
SQ   SEQUENCE   740 AA;  85251 MW;  5DCEAF7DE9843BC9 CRC64;
     MGSKDVNSQR HQRLLRNIEI TDNVHAVTAN EIARNPDGYA RQTRAKLAYH PRDEKTELQV
     KPNLQWSLPD DAKEANALSS HVEFIKVDPV RGTFNKHIVK LRYDPRKLLS FDNLINNAAP
     DPQKYHVDFE IREPETLFNR IDNECSKPYR CAIGDRRDYS TQRTTPSLKD REFFQSLLHK
     AAPASYYNGN LLLAFNEAEE REITNPKKNK SRKAPSKIEY IYFRDHEIKT WYTAPYPEEF
     NKNKILYICE YCLKYMNSRY VIHRHQLKCS LRHPPGNEIY REGNISIWEV DGRENVIYCQ
     NLCLLAKLFL NSKTLYYDVE PFIFYVLTER EDTGEESQFH FVGYFSKEKL TSTDYNLSCI
     LTLPIYQRKG YGHFLVDFSY LLTRREYKWG TPEKPLSDLG LLSYRNFWKT KICEVLGELK
     EEINHAEKKG EILHCSIEDL SNLTGMIPTD VVFGLEQIGA LHYYKGESKL QFAIKIDNWS
     LIDEVNNARK SKGYRALVPE KLVWKPMIFG PSCGINAMGT MIETTTGAAR STATGQQNGI
     DTFKNSVSVL VNFLRDDIED PRSMEAICQQ KIHDQQGRHF DTSKINLMTL AFNAPVSRRL
     KNSASSLVSV PNRYDDNETN NNTFSAPNGG ADLGIVDPEL LEETEQIDEE DEDNDLNETL
     ADGDTIGDEE VKFSSTSEDE EEDEDEEIPG RGVSSSQGRF SRTRSGRAIN SHRVIDSDEH
     EEEHIATRRL RSMDPLLKNL
//

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