(data stored in SCRATCH zone)

SWISSPROT: C5DCR8_LACTC

ID   C5DCR8_LACTC            Unreviewed;       986 AA.
AC   C5DCR8;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-4 specific {ECO:0000256|PIRNR:PIRNR037104};
DE            EC=2.1.1.43 {ECO:0000256|PIRNR:PIRNR037104};
GN   OrderedLocusNames=KLTH0B05280g {ECO:0000313|EMBL:CAR21579.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21579.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21579.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Catalytic component of the COMPASS (Set1C) complex that
CC       specifically mono-, di- and trimethylates histone H3 to form
CC       H3K4me1/2/3, which subsequently plays a role in telomere length
CC       maintenance and transcription elongation regulation.
CC       {ECO:0000256|PIRNR:PIRNR037104}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000256|PIRNR:PIRNR037104, ECO:0000256|PROSITE-
CC         ProRule:PRU00905, ECO:0000256|SAAS:SAAS01127263};
CC   -!- SUBUNIT: Component of the COMPASS (Set1C) complex.
CC       {ECO:0000256|PIRNR:PIRNR037104}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR037104,
CC       ECO:0000256|SAAS:SAAS00574581}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000256|PROSITE-
CC       ProRule:PRU00905}.
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DR   EMBL; CU928166; CAR21579.1; -; Genomic_DNA.
DR   RefSeq; XP_002552017.1; XM_002551971.1.
DR   STRING; 381046.XP_002552017.1; -.
DR   EnsemblFungi; CAR21579; CAR21579; KLTH0B05280g.
DR   GeneID; 8290855; -.
DR   KEGG; lth:KLTH0B05280g; -.
DR   HOGENOM; HOG000066111; -.
DR   InParanoid; C5DCR8; -.
DR   KO; K11422; -.
DR   OMA; PIAAKEM; -.
DR   OrthoDB; 1017537at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR024657; COMPASS_Set1_N-SET.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR017111; Set1.
DR   InterPro; IPR024636; SET_assoc.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF11764; N-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF11767; SET_assoc; 1.
DR   PIRSF; PIRSF037104; Histone_H3-K4_mtfrase_Set1_fun; 1.
DR   SMART; SM01291; N-SET; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51572; SAM_MT43_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCR8.
DR   SWISS-2DPAGE; C5DCR8.
KW   Chromatin regulator {ECO:0000256|PIRNR:PIRNR037104};
KW   Chromosome {ECO:0000256|PIRNR:PIRNR037104};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Methyltransferase {ECO:0000256|PIRNR:PIRNR037104, ECO:0000256|PROSITE-
KW   ProRule:PRU00905};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR037104,
KW   ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   S-adenosyl-L-methionine {ECO:0000256|PIRNR:PIRNR037104,
KW   ECO:0000256|PROSITE-ProRule:PRU00905, ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|PIRNR:PIRNR037104, ECO:0000256|PROSITE-
KW   ProRule:PRU00905}.
FT   DOMAIN      844    961       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      970    986       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   COILED      288    308       {ECO:0000256|SAM:Coils}.
FT   COILED      480    502       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   986 AA;  112610 MW;  0E91960FBF0F2422 CRC64;
     MSDYYGRGYD SPYQRYSRGH NGRRAGRRHG GRPPKRESHQ YGYSRRDEYL HGETYFPPSS
     RMSKPVNAVV EPLRPKPQLR FNNDSFREKY HYFDPVSEKL LHRDEMKSWA SEKLPKTGYV
     IVQDQSKDKT RAVMKPRCPD QKAVDPRSQS SPSPESGVYR KRRNQLVSLP RLVYDKHSVG
     PPPPNEIVVY PVFRDHSSAV QDIAIKNYFS TFGEISHFQS FNDPISALPL YVYVVRYTGP
     PGNLDAPFRA AYKAAKTFEN SHYFVSGFKF AVSINRANYS QKIVDGFIQD NIKQAAKIKK
     EVERQNSQKQ ISSGPQAKRL PRDLERVVNG RPSLLVLKRF ISIHGLTVED FKIKLAKYKF
     SRVLNHSTGI YIVFNDISDA RACMFVENDV LAMPSKRRRT PVKVRFSLIE SQPSIVATVK
     RDGLRDQKKT YASEEQLLET AADLIIDELG RALDRDIKRR VIGPLVFDSL NPANYPAITA
     KKDEEEERKS EQRRVAAEQK QDQQSKSASF DIFNLYGARF RKKNYIKSQI GEQSEPEYES
     KLKFSSSLKD SGQEKPMAHL LNESSRSNTP LAAENFKSDD EQAQSAVEDD EDEEGFSDVS
     ELPEKKIKTG SSEATTPETE SNKYVLNSSR IQELLRIPEK YRPDASEEPK TIYPQDDFDS
     YEFSSVSLGD FQRAVKDEED FETLKNILNP PSSALSSNEE YILHSLVHEV STEAEERHKV
     SKLQTSANEV PFDESLRSSA GSFKAGGFKK IPDKLKNCYL PHRRKLHQPL NTVYNHQDTP
     EAVTDVHRNE SEKLDMDAHA QEVSSSRVNR AINRRFQQDI EAQKAMIGSE SELLTLNQLT
     KRKKPVTFAR SAIHNWGLYA LEPIAAKEMI IEYVGEILRQ PVAEMRERTY LKSGIGSSYL
     FRVDESTVID ATKKGGIARF INHCCDPSCT AKIIRVGGRK RIVIYALRDI AANEELTYDY
     KFERETDDEE RLPCFCGAPT CKGFLN
//

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