(data stored in SCRATCH zone)

SWISSPROT: C5DCW3_LACTC

ID   C5DCW3_LACTC            Unreviewed;       129 AA.
AC   C5DCW3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   11-DEC-2019, entry version 52.
DE   RecName: Full=Prefoldin subunit 4 {ECO:0000256|PIRNR:PIRNR016477};
GN   OrderedLocusNames=KLTH0B06292g {ECO:0000313|EMBL:CAR21624.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21624.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21624.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins. {ECO:0000256|PIRNR:PIRNR016477}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000256|PIRNR:PIRNR016477}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000256|PIRNR:PIRNR016477}.
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DR   EMBL; CU928166; CAR21624.1; -; Genomic_DNA.
DR   RefSeq; XP_002552062.1; XM_002552016.1.
DR   STRING; 381046.XP_002552062.1; -.
DR   EnsemblFungi; CAR21624; CAR21624; KLTH0B06292g.
DR   GeneID; 8290901; -.
DR   KEGG; lth:KLTH0B06292g; -.
DR   HOGENOM; HOG000204477; -.
DR   InParanoid; C5DCW3; -.
DR   KO; K09550; -.
DR   OMA; IQYKIGD; -.
DR   OrthoDB; 1459797at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0016272; C:prefoldin complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR002777; PFD_beta-like.
DR   InterPro; IPR016661; PFDN4.
DR   InterPro; IPR009053; Prefoldin.
DR   PANTHER; PTHR21100; PTHR21100; 1.
DR   Pfam; PF01920; Prefoldin_2; 1.
DR   PIRSF; PIRSF016477; Prefoldin_subunit_4; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCW3.
DR   SWISS-2DPAGE; C5DCW3.
KW   Chaperone {ECO:0000256|PIRNR:PIRNR016477};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   COILED          75..109
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   129 AA;  15077 MW;  3AE5BC976E56B24A CRC64;
     MDLLPEGKKN TVQVLYEDQQ KINEFSKLIM RKDAINQELA HYKQEKGYLD DVSLEIELID
     EDEQIQYRIG EAFVFMKQSE VVEQLEKDAE ALDQKIEELE DADSEISSRT SELKTVLYAK
     FGDNINLER
//

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