(data stored in SCRATCH zone)

SWISSPROT: C5DD48_LACTC

ID   C5DD48_LACTC            Unreviewed;       483 AA.
AC   C5DD48;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 52.
DE   RecName: Full=Cysteine protease {ECO:0000256|RuleBase:RU363115};
DE            EC=3.4.22.- {ECO:0000256|RuleBase:RU363115};
GN   OrderedLocusNames=KLTH0B08272g {ECO:0000313|EMBL:CAR21709.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21709.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21709.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Cysteine protease required for the cytoplasm to vacuole
CC       transport (Cvt) and autophagy. {ECO:0000256|RuleBase:RU363115}.
CC   -!- FUNCTION: Required for selective autophagic degradation of the
CC       nucleus (nucleophagy) as well as for mitophagy which contributes
CC       to regulate mitochondrial quantity and quality by eliminating the
CC       mitochondria to a basal level to fulfill cellular energy
CC       requirements and preventing excess ROS production.
CC       {ECO:0000256|RuleBase:RU363115}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU363115,
CC       ECO:0000256|SAAS:SAAS01046728}. Nucleus
CC       {ECO:0000256|RuleBase:RU363115}.
CC   -!- SIMILARITY: Belongs to the peptidase C54 family.
CC       {ECO:0000256|RuleBase:RU363115, ECO:0000256|SAAS:SAAS01046731}.
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DR   EMBL; CU928166; CAR21709.1; -; Genomic_DNA.
DR   RefSeq; XP_002552147.1; XM_002552101.1.
DR   STRING; 381046.XP_002552147.1; -.
DR   MEROPS; C54.001; -.
DR   EnsemblFungi; CAR21709; CAR21709; KLTH0B08272g.
DR   GeneID; 8290987; -.
DR   KEGG; lth:KLTH0B08272g; -.
DR   HOGENOM; HOG000034154; -.
DR   InParanoid; C5DD48; -.
DR   KO; K08342; -.
DR   OMA; WFVDIPD; -.
DR   OrthoDB; 431748at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR005078; Peptidase_C54.
DR   PANTHER; PTHR22624; PTHR22624; 1.
DR   Pfam; PF03416; Peptidase_C54; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DD48.
DR   SWISS-2DPAGE; C5DD48.
KW   Autophagy {ECO:0000256|RuleBase:RU363115,
KW   ECO:0000256|SAAS:SAAS01046725};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Cytoplasm {ECO:0000256|RuleBase:RU363115,
KW   ECO:0000256|SAAS:SAAS01046727};
KW   Hydrolase {ECO:0000256|RuleBase:RU363115,
KW   ECO:0000256|SAAS:SAAS01046733};
KW   Nucleus {ECO:0000256|RuleBase:RU363115};
KW   Protease {ECO:0000256|RuleBase:RU363115,
KW   ECO:0000256|SAAS:SAAS01046741};
KW   Protein transport {ECO:0000256|RuleBase:RU363115,
KW   ECO:0000256|SAAS:SAAS01046735};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Thiol protease {ECO:0000256|SAAS:SAAS01046736};
KW   Transport {ECO:0000256|SAAS:SAAS01046738}.
SQ   SEQUENCE   483 AA;  54343 MW;  485FDE16B6A65899 CRC64;
     MFKFAKCQCF NHNTLFRQQE YSRATAMEFL QKVSQQLFEP ENADQDNELV VLGRRYEANG
     SNERKPDEGE AVSTGVFSQL FHRERGWNPE FLLEVHSLLH FTYRTKFEPI PKDPNGPSPM
     NFGTLFRDNP LNSFESAINH PDCFCSDIGW GCMIRTGQAL LGNALARLRS PPEEKQLIGW
     FEDRSSAPFS LHNFVREGNA LSRKPPGEWF GPSATSRSIQ SLVHAFPQCG LNHCIISTDS
     GDVYEEDVGP ILEREPQATI LLLLGVKLGL NNVNSRYWPD VKHILGSSFS VGIAGGRPSS
     SLYFFGYQGD YLFYLDPHTS QLDLASCATD NEKYESVHSA RFNKVHFSEL DPSMLIGVLI
     QGLDDWDAWK SYIDRSQILH VLPHRPRDYF MDEPDDSASE NDGIPGSRDS QDSQGPAIDG
     DYVDVAPMVQ HAGSCRDDEF QDVKCKNQKI LVVGDHDSTT ADTEIERVLV EHETVPLIAS
     TRP
//

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