(data stored in SCRATCH zone)

SWISSPROT: C6B0E5_RHILS

ID   C6B0E5_RHILS            Unreviewed;       145 AA.
AC   C6B0E5;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 63.
DE   RecName: Full=Large-conductance mechanosensitive channel {ECO:0000256|HAMAP-Rule:MF_00115, ECO:0000256|SAAS:SAAS00806423};
GN   Name=mscL {ECO:0000256|HAMAP-Rule:MF_00115};
GN   OrderedLocusNames=Rleg_0253 {ECO:0000313|EMBL:ACS54564.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54564.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54564.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54564.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Channel that opens in response to stretch forces in the
CC       membrane lipid bilayer. May participate in the regulation of
CC       osmotic pressure changes within the cell. {ECO:0000256|HAMAP-
CC       Rule:MF_00115, ECO:0000256|SAAS:SAAS00806431}.
CC   -!- SUBUNIT: Homopentamer. {ECO:0000256|HAMAP-Rule:MF_00115,
CC       ECO:0000256|SAAS:SAAS00806422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_00115}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_00115}.
CC   -!- SIMILARITY: Belongs to the MscL family. {ECO:0000256|HAMAP-
CC       Rule:MF_00115, ECO:0000256|SAAS:SAAS00694839}.
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DR   EMBL; CP001622; ACS54564.1; -; Genomic_DNA.
DR   RefSeq; WP_012755977.1; NC_012850.1.
DR   ProteinModelPortal; C6B0E5; -.
DR   EnsemblBacteria; ACS54564; ACS54564; Rleg_0253.
DR   KEGG; rlg:Rleg_0253; -.
DR   HOGENOM; HOG000226782; -.
DR   KO; K03282; -.
DR   OMA; YGSFIQT; -.
DR   OrthoDB; POG091H07L6; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   HAMAP; MF_00115; MscL; 1.
DR   InterPro; IPR019823; Mechanosensitive_channel_CS.
DR   InterPro; IPR001185; MS_channel.
DR   PANTHER; PTHR30266:SF3; PTHR30266:SF3; 1.
DR   Pfam; PF01741; MscL; 1.
DR   PRINTS; PR01264; MECHCHANNEL.
DR   SUPFAM; SSF81330; SSF81330; 1.
DR   TIGRFAMs; TIGR00220; mscL; 1.
DR   PROSITE; PS01327; MSCL; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B0E5.
DR   SWISS-2DPAGE; C6B0E5.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00115};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00115,
KW   ECO:0000256|SAAS:SAAS00694840};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Ion channel {ECO:0000256|HAMAP-Rule:MF_00115,
KW   ECO:0000256|SAAS:SAAS00694837};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_00115,
KW   ECO:0000256|SAAS:SAAS00694838};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00115,
KW   ECO:0000256|SAAS:SAAS00705692};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_00115,
KW   ECO:0000256|SAAS:SAAS00705668};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00115,
KW   ECO:0000256|SAAS:SAAS00705687};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_00115,
KW   ECO:0000256|SAAS:SAAS00694846}.
FT   TRANSMEM     12     31       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00115}.
FT   TRANSMEM     38     57       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00115}.
FT   TRANSMEM     77    101       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00115}.
SQ   SEQUENCE   145 AA;  15569 MW;  8A288FB99B5B10F8 CRC64;
     MLNEFKAFIA RGNVMDLAVG VIIGGAFGGI VKSLVDDLIM PIVGAIFGGF DFSNYFLPLS
     SAVNAQSLAA AREQGAVFAY GSFLTVLINF LILAWIIFLM VKGVNTLRAQ VERQEKVAPE
     ELPAPPADVQ LLTEIRDLLA TRPTA
//

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