(data stored in SCRATCH zone)

SWISSPROT: C6B0G4_RHILS

ID   C6B0G4_RHILS            Unreviewed;        70 AA.
AC   C6B0G4;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   08-MAY-2019, entry version 60.
DE   RecName: Full=DNA gyrase inhibitor YacG {ECO:0000256|HAMAP-Rule:MF_00649, ECO:0000256|SAAS:SAAS00382377};
GN   Name=yacG {ECO:0000256|HAMAP-Rule:MF_00649};
GN   OrderedLocusNames=Rleg_0272 {ECO:0000313|EMBL:ACS54583.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54583.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54583.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54583.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Inhibits all the catalytic activities of DNA gyrase by
CC       preventing its interaction with DNA. Acts by binding directly to
CC       the C-terminal domain of GyrB, which probably disrupts DNA binding
CC       by the gyrase. {ECO:0000256|HAMAP-Rule:MF_00649,
CC       ECO:0000256|SAAS:SAAS00085449}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00649};
CC       Note=Binds 1 zinc ion. {ECO:0000256|HAMAP-Rule:MF_00649};
CC   -!- SUBUNIT: Interacts with GyrB. {ECO:0000256|HAMAP-Rule:MF_00649,
CC       ECO:0000256|SAAS:SAAS00085444}.
CC   -!- SIMILARITY: Belongs to the DNA gyrase inhibitor YacG family.
CC       {ECO:0000256|HAMAP-Rule:MF_00649, ECO:0000256|SAAS:SAAS00570156}.
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DR   EMBL; CP001622; ACS54583.1; -; Genomic_DNA.
DR   RefSeq; WP_012755993.1; NC_012850.1.
DR   EnsemblBacteria; ACS54583; ACS54583; Rleg_0272.
DR   GeneID; 23434386; -.
DR   KEGG; rlg:Rleg_0272; -.
DR   HOGENOM; HOG000255917; -.
DR   KO; K09862; -.
DR   OMA; CSNRCRE; -.
DR   OrthoDB; 2071775at2; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0008657; F:DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.30.50.10; -; 1.
DR   HAMAP; MF_00649; DNA_gyrase_inhibitor_YacG; 1.
DR   InterPro; IPR005584; DNA_gyrase_inhibitor_YacG.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR36150; PTHR36150; 1.
DR   Pfam; PF03884; YacG; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B0G4.
DR   SWISS-2DPAGE; C6B0G4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00649,
KW   ECO:0000256|SAAS:SAAS00459510};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00649, ECO:0000256|SAAS:SAAS00459506}.
FT   METAL        20     20       Zinc. {ECO:0000256|HAMAP-Rule:MF_00649}.
FT   METAL        23     23       Zinc. {ECO:0000256|HAMAP-Rule:MF_00649}.
FT   METAL        35     35       Zinc. {ECO:0000256|HAMAP-Rule:MF_00649}.
FT   METAL        39     39       Zinc. {ECO:0000256|HAMAP-Rule:MF_00649}.
SQ   SEQUENCE   70 AA;  7992 MW;  E4F9664867543674 CRC64;
     MPEDKKAAAK VEPLRKTRPC PECGKPSHRE HYPFCSNRCR EADLSRWLTG AYAIPVADDE
     TKADYPDEEN
//

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