(data stored in SCRATCH zone)

SWISSPROT: C6B0J8_RHILS

ID   C6B0J8_RHILS            Unreviewed;       268 AA.
AC   C6B0J8;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 56.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   OrderedLocusNames=Rleg_0306 {ECO:0000313|EMBL:ACS54617.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54617.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54617.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54617.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity.
CC       Binds linear dsDNA with 5'- and 3'- overhangs but not closed
CC       circular dsDNA nor ssDNA. Recruits and stimulates the ligase
CC       activity of LigD. {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family.
CC       {ECO:0000256|HAMAP-Rule:MF_01875}.
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DR   EMBL; CP001622; ACS54617.1; -; Genomic_DNA.
DR   RefSeq; WP_012756025.1; NC_012850.1.
DR   ProteinModelPortal; C6B0J8; -.
DR   EnsemblBacteria; ACS54617; ACS54617; Rleg_0306.
DR   KEGG; rlg:Rleg_0306; -.
DR   HOGENOM; HOG000237249; -.
DR   KO; K10979; -.
DR   OMA; QVKGYPR; -.
DR   OrthoDB; POG091H08YK; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-HAMAP.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B0J8.
DR   SWISS-2DPAGE; C6B0J8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01875}.
FT   DOMAIN       55    185       Ku. {ECO:0000259|SMART:SM00559}.
SQ   SEQUENCE   268 AA;  30367 MW;  DABBBA98E50F4876 CRC64;
     MARQTFWKGY LKLSLVTAAV SLTPATTESN KVRFHVLNRQ TKNRVESRYV DSVTHKPVAE
     RDQVKGYPRG EDDYVLLEDE EIEEVGLEST RTIEIDNFVP RGSIDWIWYD KPHFLAPEDK
     VGVEAFCVIR EAMKANDVVG IARLVLYRRE RAVLLEPLGK GIVLWTLRYG DEVRDPVAEL
     DNKTEIDSKL LALMTQLVKE ETKNWSPAMV QDPIQKRLKS MIRGKQKSLK KAAPAQKPAP
     VKSTGNVINI MDALKKSLAA EGGQKPRQ
//

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