(data stored in SCRATCH zone)

SWISSPROT: C6B1M7_RHILS

ID   C6B1M7_RHILS            Unreviewed;       188 AA.
AC   C6B1M7;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   30-AUG-2017, entry version 45.
DE   RecName: Full=dTDP-4-dehydrorhamnose 3,5-epimerase {ECO:0000256|RuleBase:RU364069};
DE            EC=5.1.3.13 {ECO:0000256|RuleBase:RU364069};
DE   AltName: Full=Thymidine diphospho-4-keto-rhamnose 3,5-epimerase {ECO:0000256|RuleBase:RU364069};
GN   OrderedLocusNames=Rleg_0437 {ECO:0000313|EMBL:ACS54746.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54746.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54746.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54746.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Catalyzes the epimerization of the C3' and C5'positions
CC       of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-
CC       hexulose. {ECO:0000256|RuleBase:RU364069}.
CC   -!- CATALYTIC ACTIVITY: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-
CC       4-dehydro-beta-L-rhamnose. {ECO:0000256|RuleBase:RU364069}.
CC   -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC       {ECO:0000256|RuleBase:RU364069}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU364069}.
CC   -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase
CC       family. {ECO:0000256|RuleBase:RU364069}.
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DR   EMBL; CP001622; ACS54746.1; -; Genomic_DNA.
DR   RefSeq; WP_012756134.1; NC_012850.1.
DR   ProteinModelPortal; C6B1M7; -.
DR   EnsemblBacteria; ACS54746; ACS54746; Rleg_0437.
DR   KEGG; rlg:Rleg_0437; -.
DR   HOGENOM; HOG000227724; -.
DR   KO; K01790; -.
DR   OMA; DVCYRID; -.
DR   OrthoDB; POG091H04OS; -.
DR   BioCyc; RLEG395491:GHX2-441-MONOMER; -.
DR   UniPathway; UPA00124; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0008830; F:dTDP-4-dehydrorhamnose 3,5-epimerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR000888; dTDP_sugar_isom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin.
DR   PANTHER; PTHR21047; PTHR21047; 1.
DR   Pfam; PF00908; dTDP_sugar_isom; 1.
DR   ProDom; PD001462; dTDP_sugar_isom; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR01221; rmlC; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B1M7.
DR   SWISS-2DPAGE; C6B1M7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Isomerase {ECO:0000256|RuleBase:RU364069,
KW   ECO:0000313|EMBL:ACS54746.1}.
SQ   SEQUENCE   188 AA;  21109 MW;  C2A677A9708B04BF CRC64;
     MYALKVEQLE IGDVKKVTPA RFGDPRGYFS EVFKDFWFRT NVADVSFVQD NESLSAQPGT
     VRGLHFQSPP FAQGKLVRCL RGALLDVAVD IRHGSPTYGK WVSAELSPEN GSQLWVPAGF
     AHGFVTLEPD TIISYKVTAL YSAEHDCGVR WNDAEIGIEW PQMDGYVLSD KDNKQPRLSE
     LPTYFQFS
//

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