(data stored in SCRATCH zone)

SWISSPROT: C6WDR7_ACTMD

ID   C6WDR7_ACTMD            Unreviewed;       400 AA.
AC   C6WDR7;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 52.
DE   SubName: Full=Homogentisate 12-dioxygenase {ECO:0000313|EMBL:ACU34062.1};
GN   OrderedLocusNames=Amir_0088 {ECO:0000313|EMBL:ACU34062.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34062.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34062.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|SAAS:SAAS00382092};
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
CC       {ECO:0000256|SAAS:SAAS00570051}.
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DR   EMBL; CP001630; ACU34062.1; -; Genomic_DNA.
DR   RefSeq; WP_012782725.1; NC_013093.1.
DR   STRING; 446462.Amir_0088; -.
DR   EnsemblBacteria; ACU34062; ACU34062; Amir_0088.
DR   KEGG; ami:Amir_0088; -.
DR   eggNOG; ENOG4105F1J; Bacteria.
DR   eggNOG; COG3508; LUCA.
DR   HOGENOM; HOG000279435; -.
DR   KO; K00451; -.
DR   OMA; PYNHSNI; -.
DR   OrthoDB; POG091H04EK; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:InterPro.
DR   GO; GO:0006570; P:tyrosine metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin.
DR   PANTHER; PTHR11056; PTHR11056; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WDR7.
DR   SWISS-2DPAGE; C6WDR7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Dioxygenase {ECO:0000256|SAAS:SAAS00084228,
KW   ECO:0000313|EMBL:ACU34062.1}; Iron {ECO:0000256|SAAS:SAAS00084220};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00084212};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00084208};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213}.
SQ   SEQUENCE   400 AA;  43430 MW;  B0A741E69471A75A CRC64;
     MPYYRQVGDI PRKRHTQFRS PDGSLYAEEL MGVEGFSADS ALLYHRHLPT AIVDAVTVPD
     TRGPLVPNLP LKPRHFRTEP LVGSDPGGPG GPGGAADAVT GRRVLFGNAD VVICFAAATE
     PSPLYRNAFG DELLYVQSGE GVVETIYGAL VVESGDYVVL PTSCTYRLAP RTPMRLLVLE
     ATGHIGPPKR YLSARGQFLE HSPYCERDLR GPAEPLLVDG EDVDVLVRHR AGLTRMTYAA
     HPFDVVGWDG CLYPWVFNIG DFEPITGRVH QPPPVHQTFE GPNFVVCSFV PRKVDYHPLA
     VPVPYNHANV DSDELMFYVG GDYEARKGSG IGLGSLSLHP AGCAHGPQPG AVEASLGAES
     FDETAVMVDT FRPLELGEAA LAGEDARYAW SWSRRGPDLD
//

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