(data stored in SCRATCH zone)

SWISSPROT: C6WDZ0_ACTMD

ID   C6WDZ0_ACTMD            Unreviewed;       394 AA.
AC   C6WDZ0;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   08-MAY-2019, entry version 54.
DE   SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:ACU34135.1};
GN   OrderedLocusNames=Amir_0164 {ECO:0000313|EMBL:ACU34135.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34135.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34135.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- SIMILARITY: Belongs to the thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; CP001630; ACU34135.1; -; Genomic_DNA.
DR   RefSeq; WP_012782798.1; NC_013093.1.
DR   STRING; 446462.Amir_0164; -.
DR   EnsemblBacteria; ACU34135; ACU34135; Amir_0164.
DR   KEGG; ami:Amir_0164; -.
DR   eggNOG; ENOG4105CHU; Bacteria.
DR   eggNOG; COG0183; LUCA.
DR   HOGENOM; HOG000012238; -.
DR   OMA; TDMRWGA; -.
DR   OrthoDB; 550338at2; -.
DR   BioCyc; AMIR446462:G1GEY-171-MONOMER; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WDZ0.
DR   SWISS-2DPAGE; C6WDZ0.
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Transferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ACU34135.1}.
FT   DOMAIN        6    264       Thiolase_N. {ECO:0000259|Pfam:PF00108}.
FT   DOMAIN      272    393       Thiolase_C. {ECO:0000259|Pfam:PF02803}.
FT   ACT_SITE     90     90       Acyl-thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000429-1}.
FT   ACT_SITE    351    351       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
FT   ACT_SITE    381    381       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
SQ   SEQUENCE   394 AA;  41087 MW;  38E5A1B1BAB766A0 CRC64;
     MQRPLILDAA RTPFGRYRGG LSGVRVDDLA ALPISELLRR HPDLDPARVD DVLYGNTNGA
     GEENRNIGRM AALLAGLPPT VPGASVNRLC ASGGEAIVQA SRALAMGDAD VVVAGGVEGM
     TRAPFVVPRP DRPFADRLEP VSTALGWRLV NPRMPSAWTV PLGRAAEQVA AELGITRERM
     DQYALRSHRR ASAAWDAGVH DGFAFPVQLP DGSAVRRDES VRPETSAEKL AKLKPAFSDD
     GTVTAGNSSP LNDGAAAVLL GTESLATELG VTPLGEVLGS AVTAGEPQRF TLAPVGAIRK
     LLGRLGIGGA DVDLWEINEA FAAMALSVLH HLPEVDREKV NVHGGAIAYG HPLGASMPRV
     VVDLCRHLRA RGGGVGVAAA CVGVGQGMAI AVRV
//

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