(data stored in SCRATCH zone)

SWISSPROT: C6WF98_ACTMD

ID   C6WF98_ACTMD            Unreviewed;       390 AA.
AC   C6WF98;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 55.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   OrderedLocusNames=Amir_0261 {ECO:0000313|EMBL:ACU34230.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34230.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34230.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00693862}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00693876}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001630; ACU34230.1; -; Genomic_DNA.
DR   STRING; 446462.Amir_0261; -.
DR   EnsemblBacteria; ACU34230; ACU34230; Amir_0261.
DR   KEGG; ami:Amir_0261; -.
DR   eggNOG; ENOG4105DRC; Bacteria.
DR   eggNOG; COG3004; LUCA.
DR   HOGENOM; HOG000218489; -.
DR   KO; K03313; -.
DR   OMA; WHTPFGF; -.
DR   OrthoDB; POG091H05CU; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341:SF2; PTHR30341:SF2; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WF98.
DR   SWISS-2DPAGE; C6WF98.
KW   Antiport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693867};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693865};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693875};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693879};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Sodium {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693859};
KW   Sodium transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693872};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693873};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693863};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693869}.
FT   TRANSMEM     21     41       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM     61     78       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM     90    114       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    126    147       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    154    174       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    180    196       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    259    278       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    290    318       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    330    354       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    360    380       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
SQ   SEQUENCE   390 AA;  39829 MW;  CE76543A9CBFCD20 CRC64;
     MSSPARKPAA DFARYLRTET TGGIVLLVAT AIALLWANSP LGDSYTALRE THLGPLTIGD
     WVKDGLLAVF FFVAGLELKR ELVVGELNSL KAAALPVIAA VGGMVVPALV ALGFSWGEPG
     AGQAWAIPMA TDIAFALGVL AIAGSALPSS VRVFLLSLAV VDDLGAIAVI AVLFTSGLEL
     LAVLAAVALL ALYAFLQHKR VTATWLYVPI AVGAWVAVHE AGVHATIAGV ALGLLTRVRA
     DEGEDEAPAA RLEHRLQPWS AGLVVPLFAL FAAGVPIGGD ALRALVDDPI ALGVVAGLVL
     GKVIGILGFS ALAVRLRLAV WPSGAGPRDV AAVGVLGGVG FTVSLLIADL ALAGEAAERA
     KAAVLIASLL ASLIAAVLLV RRGRAHRDSD
//

If you have problems or comments...

PBIL Back to PBIL home page