(data stored in SCRATCH zone)

SWISSPROT: C6WGM9_ACTMD

ID   C6WGM9_ACTMD            Unreviewed;       469 AA.
AC   C6WGM9;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 64.
DE   SubName: Full=Histidine kinase {ECO:0000313|EMBL:ACU34345.1};
GN   OrderedLocusNames=Amir_0378 {ECO:0000313|EMBL:ACU34345.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34345.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34345.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-
CC       phospho-L-histidine. {ECO:0000256|SAAS:SAAS00703347}.
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DR   EMBL; CP001630; ACU34345.1; -; Genomic_DNA.
DR   RefSeq; WP_012783008.1; NC_013093.1.
DR   STRING; 446462.Amir_0378; -.
DR   PRIDE; C6WGM9; -.
DR   EnsemblBacteria; ACU34345; ACU34345; Amir_0378.
DR   KEGG; ami:Amir_0378; -.
DR   eggNOG; ENOG4105BZU; Bacteria.
DR   eggNOG; ENOG410XNMH; LUCA.
DR   HOGENOM; HOG000223177; -.
DR   KO; K02484; -.
DR   OMA; MLAHIDT; -.
DR   OrthoDB; POG091H02OU; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; C6WGM9.
DR   SWISS-2DPAGE; C6WGM9.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00776324};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Kinase {ECO:0000256|SAAS:SAAS00577625, ECO:0000313|EMBL:ACU34345.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00833905, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00777800};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Transferase {ECO:0000256|SAAS:SAAS00577260};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00833930,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00833995,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00577723}.
FT   TRANSMEM    156    179       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      180    239       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      254    469       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   469 AA;  50839 MW;  39E055DE2A9FF084 CRC64;
     MRELVTGRRM RLGTRLALGL GALALAVFGL VGALVVTSME DYLARKLDAQ MKSTQIAQEK
     DFKENGDVLG PVYGWYYAVY EVRDGVAAPL PTHKLPDDDR PMAKVATLVT GSQPVFKTVH
     FEGEGTYRVR GCPAGNGTVL VSAAPMDDLT TTVQQLTMVL VALFALALVA LVVVGRAVLR
     RGLQPLSEMA RTAHDITSHD LTDSARLPVR SEGSYGGVEV AELRTAFNTM LEHIDSSLAA
     RTAAEQRLRR FIADASHELR TPLTSIRGYA DLFRYAAANA PEEREAHLEK LRAEAARMSV
     LLEELLLLAR LDSAEAELPV RPENGDLVEL VGQAVDAFRV ARPGHPVALA VAHPRVPMRF
     DAGRLRQVLD NLLTNAAVHT PKGTAVSVSV DVVGGDAVVR VSDSGPGIPA RDQERIFDRF
     YRVDHSRTRD RGGSGLGLAV ARSLVEAHRG RLDLESRPGS TTFTITLPR
//

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