(data stored in SCRATCH zone)

SWISSPROT: C6WHV8_ACTMD

ID   C6WHV8_ACTMD            Unreviewed;       540 AA.
AC   C6WHV8;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   RecName: Full=60 kDa chaperonin {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419};
DE   AltName: Full=GroEL protein {ECO:0000256|HAMAP-Rule:MF_00600};
DE   AltName: Full=Protein Cpn60 {ECO:0000256|HAMAP-Rule:MF_00600};
GN   Name=groL {ECO:0000256|HAMAP-Rule:MF_00600};
GN   Synonyms=groEL {ECO:0000256|HAMAP-Rule:MF_00600};
GN   OrderedLocusNames=Amir_0442 {ECO:0000313|EMBL:ACU34409.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34409.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34409.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- FUNCTION: Prevents misfolding and promotes the refolding and
CC       proper assembly of unfolded polypeptides generated under stress
CC       conditions. {ECO:0000256|HAMAP-Rule:MF_00600,
CC       ECO:0000256|RuleBase:RU000419}.
CC   -!- SUBUNIT: Oligomer of 14 subunits composed of two stacked rings of
CC       7 subunits. {ECO:0000256|HAMAP-Rule:MF_00600,
CC       ECO:0000256|RuleBase:RU000419}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}.
CC   -!- SIMILARITY: Belongs to the chaperonin (HSP60) family.
CC       {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000418}.
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DR   EMBL; CP001630; ACU34409.1; -; Genomic_DNA.
DR   RefSeq; WP_012783072.1; NC_013093.1.
DR   STRING; 446462.Amir_0442; -.
DR   EnsemblBacteria; ACU34409; ACU34409; Amir_0442.
DR   KEGG; ami:Amir_0442; -.
DR   eggNOG; ENOG4105CJ9; Bacteria.
DR   eggNOG; COG0459; LUCA.
DR   HOGENOM; HOG000076290; -.
DR   KO; K04077; -.
DR   OMA; TDTDKME; -.
DR   OrthoDB; POG091H00E7; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0042026; P:protein refolding; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.10.560.10; -; 2.
DR   Gene3D; 3.50.7.10; -; 1.
DR   HAMAP; MF_00600; CH60; 1.
DR   InterPro; IPR018370; Chaperonin_Cpn60_CS.
DR   InterPro; IPR001844; Chaprnin_Cpn60.
DR   InterPro; IPR002423; Cpn60/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom.
DR   InterPro; IPR027413; GROEL-like_equatorial.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   PRINTS; PR00298; CHAPERONIN60.
DR   SUPFAM; SSF52029; SSF52029; 1.
DR   TIGRFAMs; TIGR02348; GroEL; 1.
DR   PROSITE; PS00296; CHAPERONINS_CPN60; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WHV8.
DR   SWISS-2DPAGE; C6WHV8.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00600};
KW   Chaperone {ECO:0000256|HAMAP-Rule:MF_00600};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00600};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213}.
FT   COILED      384    407       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   540 AA;  56574 MW;  BE1B7494B1093644 CRC64;
     MAKMIAFDED ARRGLERGMN ILADAVKVTL GPKGRNVVLE KKWGAPTITN DGVSIAKEIE
     LEDPWEKIGA ELVKEVAKKT DDVAGDGTTT ATVLAQALVR EGLRNVAAGA NPLGLKRGIE
     KAVEAVTEQL LKTAKEVETK EQIAATASIS AGDSTIGELI AEAMDKVGKE GVITVEESNA
     LGLELELTEG MRFDKGYISG YFVSDPERQE AVLEDPYILL YGSKIASVKD LLPLLEKVMQ
     SGKPLLIISE DVEGEALATL VVNKIRGTFK SVAVKAPGFG DRRKAILQDI AILTGGQVIT
     EDVGLKLDTA DLSLLGKARK VVVTKDETTV VEGSGDAEQI QGRVNQIRAE IEKSDSDYDR
     EKLQERLAKL AGGVAVIKAG AATEVELKER KHRIEDAVRN AKAAVEEGIV AGGGVALLQA
     AEAAFAGLKL EGDEATGANI VKVAVEAPLK QIAVNAGLEG GVVVEKVKGL PVGHGLNAAT
     GVYEDLLAAG VPDPTKVTRS ALQNAASIAA LFLTTEAVVA DKPEKAGAAP AMPDAGGMDF
//

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