(data stored in SCRATCH zone)

SWISSPROT: C6WHX4_ACTMD

ID   C6WHX4_ACTMD            Unreviewed;      1092 AA.
AC   C6WHX4;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 56.
DE   RecName: Full=Histidine kinase {ECO:0000256|SAAS:SAAS00703354};
DE            EC=2.7.13.3 {ECO:0000256|SAAS:SAAS00703354};
GN   OrderedLocusNames=Amir_0458 {ECO:0000313|EMBL:ACU34425.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34425.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34425.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-
CC       phospho-L-histidine. {ECO:0000256|SAAS:SAAS00703347}.
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DR   EMBL; CP001630; ACU34425.1; -; Genomic_DNA.
DR   STRING; 446462.Amir_0458; -.
DR   EnsemblBacteria; ACU34425; ACU34425; Amir_0458.
DR   KEGG; ami:Amir_0458; -.
DR   eggNOG; ENOG4105CM5; Bacteria.
DR   eggNOG; ENOG410XSDD; LUCA.
DR   HOGENOM; HOG000253142; -.
DR   OMA; TTSLVML; -.
DR   OrthoDB; POG091H0FKB; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR013587; Nitrate/nitrite_sensing.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF08376; NIT; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   4: Predicted;
DR   PRODOM; C6WHX4.
DR   SWISS-2DPAGE; C6WHX4.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00776284};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Kinase {ECO:0000256|SAAS:SAAS00577625};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00776426};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Transferase {ECO:0000256|SAAS:SAAS00577260};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00577723}.
FT   TRANSMEM     46     65       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    351    371       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      552    665       HATPase_c. {ECO:0000259|SMART:SM00387}.
SQ   SEQUENCE   1092 AA;  117442 MW;  863AB2DA972E6164 CRC64;
     MGDGLAALRD GTVTESTGTG LTTGVRQGEA RTASWRLQNW RLPTKLGAVL LIPTVAALAL
     GGLRVQSDLA NATQFSRLAN QVQLETAVAD LVHQLQRERD LSTWYVASSK QIESVALDRQ
     LVRVSDAVET LKSKIIDLSG DLAPETVERF RGTAEQLTRL NSLRSAVRET QYPSDAVLRV
     YSESVESLLD LGEQAIGGID DPELARLHLA TNAMARIKEQ ESQKRGILFD VFQRGSFAAN
     QERALLAVNA ELDAARNDFR KSATPDQAKI YDDTVTGLII DTANNMQETA LNLAGTTSGF
     GDISPKGWDV SSTLTVNKTR QVEVMLIEQL QRLSDERTGE ARAAAFYDSG VVLGALLMAL
     VMALFVARSI LNPLRLLRRT ALDVADKGLP EAVEKILADP NPQEAAKTAI APVPITTREE
     VGQVARAFDA VHGEAVRLAA EQAMLRDNVN AMFVNLSRRS QALVERQLNL IDRLEQDEQD
     PDQLASLFEL DHLATRMRRN SENLLMLSGT DLSRRLTRPV PVAEVLGAAV SEVEQYARVQ
     VGQTPELTVQ GRAVNDLVHL IAELLDNATA FSDPVTKVTV RTARTRKGEL AIEIQDRGVG
     MSDQDLRDAN ERLANPPDVD VAVSRRMGLY VVARLAKRHD VKVRLRGNED IEGGTTALVT
     VPEALVTSAG QTAHPMGADL IGSPSAPAPS AFPSPNTAQR ASGIAGAFGG GNGTAGVTSR
     HDEESSYPAV SFMSTDVDAD ATRAPYRAEV PQETSAEISQ ASWLPMVEEQ PPAVARDAQN
     EPTGTFGSPT LFTAYEDRDA PQADHEHGYQ TTQFPAVDDS ANAFAPFAAP LPEPEPEPEP
     EPEPEPVVFQ RSSAPRASAP ARPVVDDTPT ERLPIYEAVL SQWFQSVGSE TSAATTQAVP
     PAPAAPAPRP ARQDVQPEPQ REEAPLPTRK PRPVSEQAQE AAAPSSAIEN GLPKRQPGSQ
     SNMSKRTLET SRVSEPEAVQ AEPAAKASPA SVWQSPADEG WQAAQSLLSS TPDATTQAGL
     PKRKPKAQLV PGSAAPLAGA TQQPQQPPLP PRSADVIRGR MSSLQQGVRR GRHALIDAYA
     GDMSSRQDEE QE
//

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