(data stored in SCRATCH zone)

SWISSPROT: C6WI20_ACTMD

ID   C6WI20_ACTMD            Unreviewed;       237 AA.
AC   C6WI20;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   05-JUL-2017, entry version 56.
DE   RecName: Full=Urease accessory protein UreG {ECO:0000256|HAMAP-Rule:MF_01389};
GN   Name=ureG {ECO:0000256|HAMAP-Rule:MF_01389};
GN   OrderedLocusNames=Amir_0504 {ECO:0000313|EMBL:ACU34471.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34471.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34471.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- FUNCTION: Facilitates the functional incorporation of the urease
CC       nickel metallocenter. This process requires GTP hydrolysis,
CC       probably effectuated by UreG. {ECO:0000256|HAMAP-Rule:MF_01389,
CC       ECO:0000256|SAAS:SAAS00098435}.
CC   -!- SUBUNIT: Homodimer. UreD, UreF and UreG form a complex that acts
CC       as a GTP-hydrolysis-dependent molecular chaperone, activating the
CC       urease apoprotein by helping to assemble the nickel containing
CC       metallocenter of UreC. The UreE protein probably delivers the
CC       nickel. {ECO:0000256|HAMAP-Rule:MF_01389}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01389,
CC       ECO:0000256|SAAS:SAAS00098440}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_01389,
CC       ECO:0000256|SAAS:SAAS00571589}.
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DR   EMBL; CP001630; ACU34471.1; -; Genomic_DNA.
DR   RefSeq; WP_012783134.1; NC_013093.1.
DR   ProteinModelPortal; C6WI20; -.
DR   STRING; 446462.Amir_0504; -.
DR   EnsemblBacteria; ACU34471; ACU34471; Amir_0504.
DR   KEGG; ami:Amir_0504; -.
DR   eggNOG; ENOG4107S16; Bacteria.
DR   eggNOG; COG0378; LUCA.
DR   HOGENOM; HOG000236979; -.
DR   KO; K03189; -.
DR   OMA; PYVGVDV; -.
DR   OrthoDB; POG091H08WY; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01389; UreG; 1.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR012202; NiFe-hyd/urease_mat_GTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004400; UreG.
DR   PANTHER; PTHR31715; PTHR31715; 1.
DR   Pfam; PF02492; cobW; 1.
DR   PIRSF; PIRSF005624; Ni-bind_GTPase; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00101; ureG; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WI20.
DR   SWISS-2DPAGE; C6WI20.
KW   Chaperone {ECO:0000256|HAMAP-Rule:MF_01389,
KW   ECO:0000256|SAAS:SAAS00089873};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01389,
KW   ECO:0000256|SAAS:SAAS00089900};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_01389,
KW   ECO:0000256|SAAS:SAAS00089897};
KW   Nickel insertion {ECO:0000256|HAMAP-Rule:MF_01389,
KW   ECO:0000256|SAAS:SAAS00089886};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01389,
KW   ECO:0000256|SAAS:SAAS00089889};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213}.
FT   DOMAIN       39    209       cobW. {ECO:0000259|Pfam:PF02492}.
FT   NP_BIND      43     50       GTP. {ECO:0000256|HAMAP-Rule:MF_01389}.
SQ   SEQUENCE   237 AA;  24666 MW;  135CA824996BB852 CRC64;
     MSADHGHGHG HAHPVNFDPT DAGHDPHVPA PDARRAVRIG IGGPVGSGKT ALTAALCRAL
     GGRVDLAVVT NDIYTTEDAD FLRRAGVLPT ERIEAVQTGA CPHTAIRDDI TANLDAVEEL
     EQRFPGLELV IIESGGDNLT AVFSRGLADA QVFVVDVAGG DKVPRKGGPG VTTADLLVIN
     KTDLAPLVGA DLGVMTADAH RMRGELPVIA QSLVETPDAP AVAEWVLGQL RTLATVR
//

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