(data stored in SCRATCH zone)

SWISSPROT: C7QJ99_CATAD

ID   C7QJ99_CATAD            Unreviewed;       303 AA.
AC   C7QJ99;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   07-JUN-2017, entry version 60.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00667901};
DE            EC=6.3.2.6 {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00337892};
DE   AltName: Full=SAICAR synthetase {ECO:0000256|HAMAP-Rule:MF_00137};
GN   Name=purC {ECO:0000256|HAMAP-Rule:MF_00137};
GN   OrderedLocusNames=Caci_0288 {ECO:0000313|EMBL:ACU69241.1};
OS   Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC
OS   102108 / JCM 14897).
OC   Bacteria; Actinobacteria; Catenulisporales; Catenulisporaceae;
OC   Catenulispora.
OX   NCBI_TaxID=479433 {ECO:0000313|EMBL:ACU69241.1, ECO:0000313|Proteomes:UP000000851};
RN   [1] {ECO:0000313|EMBL:ACU69241.1, ECO:0000313|Proteomes:UP000000851}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897
RC   {ECO:0000313|Proteomes:UP000000851};
RX   PubMed=21304647;
RA   Copeland A., Lapidus A., Glavina Del Rio T., Nolan M., Lucas S.,
RA   Chen F., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chain P., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Chertkov O., Brettin T., Detter J.C., Han C., Ali Z.,
RA   Tindall B.J., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Catenulispora acidiphila type strain (ID
RT   139908).";
RL   Stand. Genomic Sci. 1:119-125(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate +
CC       (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamido)succinate. {ECO:0000256|HAMAP-Rule:MF_00137,
CC       ECO:0000256|SAAS:SAAS00337907}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC       {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00337887}.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00535425}.
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DR   EMBL; CP001700; ACU69241.1; -; Genomic_DNA.
DR   RefSeq; WP_012784536.1; NC_013131.1.
DR   ProteinModelPortal; C7QJ99; -.
DR   STRING; 479433.Caci_0288; -.
DR   EnsemblBacteria; ACU69241; ACU69241; Caci_0288.
DR   KEGG; cai:Caci_0288; -.
DR   eggNOG; ENOG4105C8V; Bacteria.
DR   eggNOG; COG0152; LUCA.
DR   HOGENOM; HOG000230360; -.
DR   KO; K01923; -.
DR   OMA; EMVIRGY; -.
DR   OrthoDB; POG091H01GT; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000000851; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR001636; SAICAR_synth.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C7QJ99.
DR   SWISS-2DPAGE; C7QJ99.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00416489};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000851};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00416508, ECO:0000313|EMBL:ACU69241.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00416561};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00416526};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000851}.
FT   DOMAIN       16    272       SAICAR_synt. {ECO:0000259|Pfam:PF01259}.
SQ   SEQUENCE   303 AA;  34154 MW;  14A30D430399BB93 CRC64;
     MNRRYSERVI TGLNHLASGK IRDLYAVGDD LLLVASDKIS AFDYVLESEI PDKGRILTQL
     SMWWFRQLAD LVPNHVISAD VEQFPAELQP YKEELRGRSM LCRKLSMVQV ECVARGYLTG
     SGLAEYERTR TANGVPLPPG LVDGSRLDRP IFTPAMKAEV GQHDENVSFE DMAERIGDPE
     LAAQLKDLTL AVYSRAREIA EERGIILADT KFEFGRLRGG TLVLADEVLT PDSSRFWPAD
     EWKPGRTQSS FDKQYVRDWL SSPASGWDRK SDTPPPVLPE EVVQATRARY VEAYERLTGA
     KFD
//

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