(data stored in SCRATCH zone)

SWISSPROT: C8U1C8_ECO10

ID   C8U1C8_ECO10            Unreviewed;       271 AA.
AC   C8U1C8;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 64.
DE   RecName: Full=Co-chaperone protein DjlA {ECO:0000256|HAMAP-Rule:MF_01153};
GN   Name=djlA {ECO:0000256|HAMAP-Rule:MF_01153,
GN   ECO:0000313|EMBL:BAI28936.1};
GN   OrderedLocusNames=ECO103_0058 {ECO:0000313|EMBL:BAI28936.1};
OS   Escherichia coli O103:H2 (strain 12009 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585395 {ECO:0000313|EMBL:BAI28936.1, ECO:0000313|Proteomes:UP000000959};
RN   [1] {ECO:0000313|EMBL:BAI28936.1, ECO:0000313|Proteomes:UP000000959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12009 / EHEC {ECO:0000313|Proteomes:UP000000959};
RX   PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA   Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA   Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA   Hayashi T.;
RT   "Comparative genomics reveal the mechanism of the parallel evolution
RT   of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
CC   -!- FUNCTION: Regulatory DnaK co-chaperone. Direct interaction between
CC       DnaK and DjlA is needed for the induction of the wcaABCDE operon,
CC       involved in the synthesis of a colanic acid polysaccharide
CC       capsule, possibly through activation of the RcsB/RcsC
CC       phosphotransfer signaling pathway. The colanic acid capsule may
CC       help the bacterium survive conditions outside the host.
CC       {ECO:0000256|HAMAP-Rule:MF_01153}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01153}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01153}; Single-pass type III membrane protein
CC       {ECO:0000256|HAMAP-Rule:MF_01153}.
CC   -!- DOMAIN: The transmembrane domain is a dimerization domain.
CC       {ECO:0000256|HAMAP-Rule:MF_01153}.
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DR   EMBL; AP010958; BAI28936.1; -; Genomic_DNA.
DR   RefSeq; WP_001200573.1; NC_013353.1.
DR   SMR; C8U1C8; -.
DR   EnsemblBacteria; BAI28936; BAI28936; ECO103_0058.
DR   KEGG; eoh:ECO103_0058; -.
DR   HOGENOM; HOG000272779; -.
DR   KO; K05801; -.
DR   OMA; MQYWGKL; -.
DR   BioCyc; ECOL585395:ECO103_RS00295-MONOMER; -.
DR   Proteomes; UP000000959; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051087; F:chaperone binding; IEA:InterPro.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   Gene3D; 1.10.3680.10; -; 1.
DR   HAMAP; MF_01153; DjlA; 1.
DR   InterPro; IPR023749; DjlA.
DR   InterPro; IPR007791; DjlA_N.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR029024; TerB-like.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF05099; TerB; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C8U1C8.
DR   SWISS-2DPAGE; C8U1C8.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01153};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01153};
KW   Chaperone {ECO:0000256|HAMAP-Rule:MF_01153};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000959};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01153, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01153,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01153,
KW   ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM      1      6       Periplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01153}.
FT   TRANSMEM      6     30       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM     32    271       Cytoplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01153}.
FT   DOMAIN      205    271       J. {ECO:0000259|PROSITE:PS50076}.
FT   COILED      247    267       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   271 AA;  30565 MW;  F7A0F92DA681758F CRC64;
     MQYWGKIIGV AVALLMGGGF WGVVLGLLIG HMFDKARSRK MAWFANQRER QALFFATTFE
     VMGHLTKSKG RVTEADIHIA SQLMDRMNLH GASRTAAQNA FRVGKSDNYP LREKMRQFRS
     VCFGRFDLIR MFLEIQIQAA FADGSLHPNE RAVLYVIAEE LGISRAQFDQ FLRMMQGGAQ
     FGGGYQQQSG GGNWQQAQRG PTLEDACNVL GVKPTDDATT IKRAYRKLMS EHHPDKLVAK
     GLPPEMMEMA KQKAQEIQQA YELIKQQKGF K
//

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