(data stored in SCRATCH zone)

SWISSPROT: C8U297_ECO10

ID   C8U297_ECO10            Unreviewed;       149 AA.
AC   C8U297;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000256|HAMAP-Rule:MF_00440, ECO:0000256|SAAS:SAAS01000175};
GN   Name=ybaD {ECO:0000313|EMBL:BAI29255.1};
GN   Synonyms=nrdR {ECO:0000256|HAMAP-Rule:MF_00440};
GN   OrderedLocusNames=ECO103_0387 {ECO:0000313|EMBL:BAI29255.1};
OS   Escherichia coli O103:H2 (strain 12009 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585395 {ECO:0000313|EMBL:BAI29255.1, ECO:0000313|Proteomes:UP000000959};
RN   [1] {ECO:0000313|EMBL:BAI29255.1, ECO:0000313|Proteomes:UP000000959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12009 / EHEC {ECO:0000313|Proteomes:UP000000959};
RX   PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA   Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA   Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA   Hayashi T.;
RT   "Comparative genomics reveal the mechanism of the parallel evolution
RT   of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000256|HAMAP-Rule:MF_00440,
CC       ECO:0000256|SAAS:SAAS01000154}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000256|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000256|HAMAP-
CC       Rule:MF_00440, ECO:0000256|SAAS:SAAS00918952}.
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DR   EMBL; AP010958; BAI29255.1; -; Genomic_DNA.
DR   RefSeq; WP_000543535.1; NC_013353.1.
DR   EnsemblBacteria; BAI29255; BAI29255; ECO103_0387.
DR   KEGG; eoh:ECO103_0387; -.
DR   HOGENOM; HOG000097653; -.
DR   KO; K07738; -.
DR   OMA; RFTTYET; -.
DR   BioCyc; ECOL585395:ECO103_RS02030-MONOMER; -.
DR   Proteomes; UP000000959; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
DR   PRODOM; C8U297.
DR   SWISS-2DPAGE; C8U297.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00440, ECO:0000256|PROSITE-
KW   ProRule:PRU00492, ECO:0000256|SAAS:SAAS00460659};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000959};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00440,
KW   ECO:0000256|SAAS:SAAS00918953};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00440,
KW   ECO:0000256|SAAS:SAAS01000174};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00440,
KW   ECO:0000256|PROSITE-ProRule:PRU00492, ECO:0000256|SAAS:SAAS00460691};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_00440,
KW   ECO:0000256|SAAS:SAAS00919021};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00440,
KW   ECO:0000256|SAAS:SAAS00919037};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00440,
KW   ECO:0000256|SAAS:SAAS00919032};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00440, ECO:0000256|SAAS:SAAS01000193};
KW   Zinc-finger {ECO:0000256|HAMAP-Rule:MF_00440,
KW   ECO:0000256|SAAS:SAAS01000190}.
FT   DOMAIN       49    139       ATP-cone. {ECO:0000259|PROSITE:PS51161}.
FT   ZN_FING       3     34       {ECO:0000256|HAMAP-Rule:MF_00440}.
SQ   SEQUENCE   149 AA;  17229 MW;  EFF99DD555EF2D26 CRC64;
     MHCPFCFAVD TKVIDSRLVG EGSSVRRRRQ CLVCNERFTT FEVAELVMPR VVKSNDVREP
     FNEEKLRSGM LRALEKRPVS SDDVEMAINH IKSQLRATGE REVPSKMIGN LVMEQLKKLD
     KVAYIRFASV YRSFEDIKEF GEEIARLED
//

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