(data stored in SCRATCH zone)

SWISSPROT: C8U313_ECO10

ID   C8U313_ECO10            Unreviewed;       311 AA.
AC   C8U313;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=Pyrimidine-specific ribonucleoside hydrolase RihA {ECO:0000256|HAMAP-Rule:MF_01431, ECO:0000256|SAAS:SAAS00014539};
DE            EC=3.2.-.- {ECO:0000256|HAMAP-Rule:MF_01431, ECO:0000256|SAAS:SAAS00015510};
DE   AltName: Full=Cytidine/uridine-specific hydrolase {ECO:0000256|HAMAP-Rule:MF_01431};
GN   Name=rihA {ECO:0000256|HAMAP-Rule:MF_01431,
GN   ECO:0000313|EMBL:BAI29521.1};
GN   OrderedLocusNames=ECO103_0658 {ECO:0000313|EMBL:BAI29521.1};
OS   Escherichia coli O103:H2 (strain 12009 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585395 {ECO:0000313|EMBL:BAI29521.1, ECO:0000313|Proteomes:UP000000959};
RN   [1] {ECO:0000313|EMBL:BAI29521.1, ECO:0000313|Proteomes:UP000000959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12009 / EHEC {ECO:0000313|Proteomes:UP000000959};
RX   PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA   Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA   Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA   Hayashi T.;
RT   "Comparative genomics reveal the mechanism of the parallel evolution
RT   of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
CC   -!- FUNCTION: Hydrolyzes with equal efficiency cytidine or uridine to
CC       ribose and cytosine or uracil, respectively. {ECO:0000256|HAMAP-
CC       Rule:MF_01431}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01431, ECO:0000256|SAAS:SAAS00540410}.
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DR   EMBL; AP010958; BAI29521.1; -; Genomic_DNA.
DR   RefSeq; WP_001207502.1; NC_013353.1.
DR   EnsemblBacteria; BAI29521; BAI29521; ECO103_0658.
DR   KEGG; eoh:ECO103_0658; -.
DR   HOGENOM; HOG000218839; -.
DR   KO; K01250; -.
DR   OMA; HAPDIHG; -.
DR   BioCyc; ECOL585395:ECO103_RS03430-MONOMER; -.
DR   Proteomes; UP000000959; Chromosome.
DR   GO; GO:0045437; F:uridine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01431; Pyrim_hydro_RihA; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022975; Pyrim_hydro_RihA.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
DR   PRODOM; C8U313.
DR   SWISS-2DPAGE; C8U313.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000959};
KW   Glycosidase {ECO:0000256|HAMAP-Rule:MF_01431,
KW   ECO:0000256|SAAS:SAAS00111652};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01431,
KW   ECO:0000256|SAAS:SAAS00014523, ECO:0000313|EMBL:BAI29521.1}.
FT   DOMAIN        4    300       IU_nuc_hydro. {ECO:0000259|Pfam:PF01156}.
FT   ACT_SITE    240    240       {ECO:0000256|HAMAP-Rule:MF_01431}.
SQ   SEQUENCE   311 AA;  33793 MW;  9106B17153059C8F CRC64;
     MALPILLDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPEKTLRNVL RMLTLLNRTD
     IPVAGGAVKP LMRELIIADN VHGESGLDGP ALPEPAFAPQ NCTAVELMAK TLRESAEPVT
     IVSTGPQTNV ALLLNSHPEL HSKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
     GIPVVMAGLD VTHKAQIHVE DTERFRAIGN PVSTIVAELL DFFLEYHKDE KWGFVGAPLH
     DPCTIAWLLK PELFTTVERW VGVETQGKYS QGMTVVDYYY LTGNKPNATV MVDVDRQGFV
     DLLADRLKFY A
//

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