(data stored in ACNUC8465 zone)

SWISSPROT: Q5B7Q8_EMENI

ID   Q5B7Q8_EMENI            Unreviewed;       539 AA.
AC   Q5B7Q8; C8VHJ9;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   11-DEC-2019, entry version 116.
DE   SubName: Full=MAP kinase kinase (Eurofung) {ECO:0000313|EMBL:CBF82742.1};
GN   ORFNames=ANIA_03422 {ECO:0000313|EMBL:CBF82742.1};
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321 {ECO:0000313|EMBL:CBF82742.1, ECO:0000313|Proteomes:UP000000560};
RN   [1] {ECO:0000313|Proteomes:UP000000560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC   {ECO:0000313|Proteomes:UP000000560};
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.J., Wortman J.R., Batzoglou S.,
RA   Lee S.I., Basturkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M., Hynes M., Paoletti M., Fischer R., Miller B.,
RA   Dyer P., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2] {ECO:0000313|Proteomes:UP000000560}
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC   {ECO:0000313|Proteomes:UP000000560};
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
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DR   EMBL; BN001306; CBF82742.1; -; Genomic_DNA.
DR   RefSeq; XP_661026.1; XM_655934.1.
DR   STRING; 162425.CADANIAP00009617; -.
DR   EnsemblFungi; CBF82742; CBF82742; ANIA_03422.
DR   EnsemblFungi; EAA62899; EAA62899; AN3422.2.
DR   GeneID; 2874551; -.
DR   KEGG; ani:AN3422.2; -.
DR   HOGENOM; HOG000234206; -.
DR   KO; K11226; -.
DR   OMA; REAKVMW; -.
DR   OrthoDB; 688282at2759; -.
DR   Proteomes; UP000000560; Chromosome VI.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0001411; C:hyphal tip; IDA:AspGD.
DR   GO; GO:0005635; C:nuclear envelope; IDA:AspGD.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IBA:GO_Central.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:1900376; P:regulation of secondary metabolite biosynthetic process; IMP:AspGD.
DR   GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0000909; P:sporocarp development involved in sexual reproduction; IMP:AspGD.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
DR   PRODOM; Q5B7Q8.
DR   SWISS-2DPAGE; Q5B7Q8.
KW   Kinase {ECO:0000313|EMBL:CBF82742.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000560};
KW   Transferase {ECO:0000313|EMBL:CBF82742.1}.
FT   DOMAIN          67..334
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          21..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          358..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..453
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..470
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..507
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  58909 MW;  80DE91C47E6BFAD6 CRC64;
     MADQFKARTL KRKNVKGLAL NAAPKSTSTL SNGDSQVPGA AGNGESNRTD TLEIGLEFRL
     DLRSEDLITL KELGAGNGGT VSKVMHASTK VVMARKIIRV DAKENVRKQI LRELQVGHDC
     NSPNIVTFYG AFQNEARDIV LCMEYMDCGS LDRISKDFGP IRVDVLGKIT ESILAGLVYL
     YEAHRIMHRD IKPSNVLVNS RGNIKLCDFG VATETVNSIA DTFVGTSTYM APERIQGGAY
     TVRSDVWSVG LTVMELAVGR FPFDTTDSAA GDRASAGPMG ILDLLQQIVH EPAPKLPRSD
     AFPPVLHEFV AKCLLKKSEE RPTPLELYEK DAFLAAAKRT PVDLQEWAIS MMERHNRKSY
     LAPPAPKSLK ETRESPSPAQ APSPVQKHGT SRPSRGTTGE IPLNVARDSS SHQRQHAPQS
     QSHFSSNPSH YSSNSSHYSS RSSRSSPPIS LEHLSLESKQ DEHRPTRRPS RTPLGDSSSS
     LDQSLRPSIG SRSASSHNTN SRMPLQSTAL PFRVAPTPGG YPTPNSTSWQ RRGDHMGAL
//

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