(data stored in SCRATCH zone)

SWISSPROT: C8VN79_EMENI

ID   C8VN79_EMENI            Unreviewed;       682 AA.
AC   C8VN79;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-JUL-2017, entry version 46.
DE   RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU000672};
DE            EC=1.4.3.- {ECO:0000256|RuleBase:RU000672};
GN   ORFNames=ANIA_01586 {ECO:0000313|EMBL:CBF85166.1};
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321 {ECO:0000313|EMBL:CBF85166.1, ECO:0000313|Proteomes:UP000000560};
RN   [1] {ECO:0000313|Proteomes:UP000000560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC   {ECO:0000313|Proteomes:UP000000560};
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.J., Wortman J.R.,
RA   Batzoglou S., Lee S.I., Basturkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M., Hynes M., Paoletti M., Fischer R., Miller B., Dyer P.,
RA   Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2] {ECO:0000313|Proteomes:UP000000560}
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC   {ECO:0000313|Proteomes:UP000000560};
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- COFACTOR:
CC       Name=L-topaquinone; Xref=ChEBI:CHEBI:79027;
CC         Evidence={ECO:0000256|RuleBase:RU000672};
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000672};
CC       Note=Contains 1 topaquinone per subunit.
CC       {ECO:0000256|RuleBase:RU000672};
CC   -!- COFACTOR:
CC       Name=L-topaquinone; Xref=ChEBI:CHEBI:79027;
CC         Evidence={ECO:0000256|PIRSR:PIRSR600269-51};
CC       Note=Contains 1 topaquinone per subunit.
CC       {ECO:0000256|PIRSR:PIRSR600269-51};
CC   -!- PTM: Topaquinone (TPQ) is generated by copper-dependent
CC       autoxidation of a specific tyrosyl residue.
CC       {ECO:0000256|PIRSR:PIRSR600269-51, ECO:0000256|RuleBase:RU000672}.
CC   -!- SIMILARITY: Belongs to the copper/topaquinone oxidase family.
CC       {ECO:0000256|RuleBase:RU000672}.
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DR   EMBL; BN001307; CBF85166.1; -; Genomic_DNA.
DR   STRING; 162425.CADANIAP00008219; -.
DR   EnsemblFungi; CADANIAT00008219; CADANIAP00008219; CADANIAG00008219.
DR   InParanoid; C8VN79; -.
DR   OMA; APYPRKA; -.
DR   OrthoDB; EOG092C1J1W; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0008131; F:primary amine oxidase activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0009308; P:amine metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.70.98.20; -; 1.
DR   InterPro; IPR000269; Cu_amine_oxidase.
DR   InterPro; IPR015798; Cu_amine_oxidase_C.
DR   InterPro; IPR016182; Cu_amine_oxidase_N-reg.
DR   InterPro; IPR015800; Cu_amine_oxidase_N2.
DR   PANTHER; PTHR10638; PTHR10638; 1.
DR   Pfam; PF01179; Cu_amine_oxid; 1.
DR   Pfam; PF02727; Cu_amine_oxidN2; 1.
DR   SUPFAM; SSF49998; SSF49998; 1.
DR   SUPFAM; SSF54416; SSF54416; 2.
DR   PROSITE; PS01164; COPPER_AMINE_OXID_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; C8VN79.
DR   SWISS-2DPAGE; C8VN79.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000560};
KW   Copper {ECO:0000256|RuleBase:RU000672};
KW   Metal-binding {ECO:0000256|RuleBase:RU000672};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000672};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000560};
KW   TPQ {ECO:0000256|PIRSR:PIRSR600269-50, ECO:0000256|RuleBase:RU000672}.
FT   DOMAIN        6     96       Cu_amine_oxidN2. {ECO:0000259|Pfam:
FT                                PF02727}.
FT   DOMAIN      244    655       Cu_amine_oxid. {ECO:0000259|Pfam:
FT                                PF01179}.
FT   ACT_SITE    316    316       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR600269-50}.
FT   ACT_SITE    400    400       Schiff-base intermediate with substrate;
FT                                via topaquinone. {ECO:0000256|PIRSR:
FT                                PIRSR600269-50}.
FT   MOD_RES     400    400       2',4',5'-topaquinone. {ECO:0000256|PIRSR:
FT                                PIRSR600269-51}.
SQ   SEQUENCE   682 AA;  76906 MW;  A9AB369960A9600D CRC64;
     MTGKMHPFDP LSPEEISKAA TIVRGQFPGQ SPAFRFITLK EPSKQEMMPF LESEHRGIPA
     AKRPARVSRV QVVLRGNDGA NQLRELLIDL DSTGVLKNDH LVGRHSYIDS DYMRLVESAC
     LADQRVQDEI KKLKLPPSST VIVEPWAYGT DGTYDGLERV TMCWFYLRLL DNPDANYYAY
     PLDLCAEVSE QLKVIKIYYL PSAQNDRITD QARPFDIKKI HSTAESEYHP SLRPPPRNTT
     KPYQVVQPEG PSFTIKGNHI SWEKWTMRVG FNYREGLTLH DIRYDGRSLF YRLSLSEMFV
     PYGDPRSPYP RKAAFDLGSD GAGINANNLR LGCDCLGLIK YFDGWHNTSS GEPLKLPNVV
     CCHEQDDGIL WKHTNFRTQN AVVTRARILV LQTIITVSNY EYIFAFQFGQ DASIHYEVRA
     TGILSTCPIN LGDQVPYGTI VGPGVLAPYH QHLFCLRMDP WLDGDVRNSL QVEESHPMPV
     NDPSIHNPLG VGYSTTSVIV PEETGLDLDF TKNRTFKLIN ENKINPTTKT PVGFKLLPAY
     SQMLLAHPDS YHSKRSEFGA HAVWVTRYDD EEMFPAGQYT MQSSGGEGIN SAITRRRNDP
     GSKTSVRNED IVLWHTFGST HNPRIEDWPV MPMDRMVVGL KPVNFFSGNP GLDVPVSTQE
     RNRSVLVEGD TVVSTSDACC RL
//

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