(data stored in ACNUC16935 zone)

SWISSPROT: UBB_CHICK

ID   UBB_CHICK               Reviewed;         305 AA.
AC   P0CG62; P02248; P02249; P02250; P62973; Q29120; Q91887; Q91888;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   05-JUL-2017, entry version 60.
DE   RecName: Full=Polyubiquitin-B;
DE   Contains:
DE     RecName: Full=Ubiquitin;
DE   Flags: Precursor;
GN   Name=UBB;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3025663; DOI=10.1128/MCB.6.12.4602;
RA   Bond U., Schlesinger M.J.;
RT   "The chicken ubiquitin gene contains a heat shock promoter and
RT   expresses an unstable mRNA in heat-shocked cells.";
RL   Mol. Cell. Biol. 6:4602-4610(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 149-305.
RX   PubMed=2987683; DOI=10.1128/MCB.5.5.949;
RA   Bond U., Schlesinger M.J.;
RT   "Ubiquitin is a heat shock protein in chicken embryo fibroblasts.";
RL   Mol. Cell. Biol. 5:949-956(1985).
CC   -!- FUNCTION: Ubiquitin exists either covalently attached to another
CC       protein, or free (unanchored). When covalently bound, it is
CC       conjugated to target proteins via an isopeptide bond either as a
CC       monomer (monoubiquitin), a polymer linked via different Lys
CC       residues of the ubiquitin (polyubiquitin chains) or a linear
CC       polymer linked via the initiator Met of the ubiquitin (linear
CC       polyubiquitin chains). Polyubiquitin chains, when attached to a
CC       target protein, have different functions depending on the Lys
CC       residue of the ubiquitin that is linked: Lys-6-linked may be
CC       involved in DNA repair; Lys-11-linked is involved in ERAD
CC       (endoplasmic reticulum-associated degradation) and in cell-cycle
CC       regulation; Lys-29-linked is involved in lysosomal degradation;
CC       Lys-33-linked is involved in kinase modification; Lys-48-linked is
CC       involved in protein degradation via the proteasome; Lys-63-linked
CC       is involved in endocytosis, DNA-damage responses as well as in
CC       signaling processes leading to activation of the transcription
CC       factor NF-kappa-B. Linear polymer chains formed via attachment by
CC       the initiator Met lead to cell signaling. Ubiquitin is usually
CC       conjugated to Lys residues of target proteins, however, in rare
CC       cases, conjugation to Cys or Ser residues has been observed. When
CC       polyubiquitin is free (unanchored-polyubiquitin), it also has
CC       distinct roles, such as in activation of protein kinases, and in
CC       signaling (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Ubiquitin is encoded by 4 different genes. Uba52
CC       and Rps27a genes code for a single copy of ubiquitin fused to the
CC       ribosomal proteins L40 and S27a, respectively. UBB and UBC genes
CC       code for a polyubiquitin precursor with exact head to tail
CC       repeats, the number of repeats differ between species and strains.
CC   -!- MISCELLANEOUS: For the sake of clarity sequence features are
CC       annotated only for the first chain, and are not repeated for each
CC       of the following chains.
CC   -!- SIMILARITY: Belongs to the ubiquitin family. {ECO:0000305}.
DR   EMBL; M14693; AAA49128.1; -; Genomic_DNA.
DR   EMBL; X02650; CAA26488.1; -; mRNA.
DR   RefSeq; XP_004946721.1; XM_004946664.2.
DR   UniGene; Gga.39142; -.
DR   ProteinModelPortal; P0CG62; -.
DR   SMR; P0CG62; -.
DR   STRING; 9031.ENSGALP00000038736; -.
DR   PaxDb; P0CG62; -.
DR   Ensembl; ENSGALT00000039524; ENSGALP00000038735; ENSGALG00000004509.
DR   Ensembl; ENSGALT00000061244; ENSGALP00000053353; ENSGALG00000004509.
DR   Ensembl; ENSGALT00000088679; ENSGALP00000062271; ENSGALG00000004509.
DR   GeneID; 101747587; -.
DR   KEGG; gga:101747587; -.
DR   eggNOG; KOG0001; Eukaryota.
DR   eggNOG; COG5272; LUCA.
DR   GeneTree; ENSGT00810000125435; -.
DR   InParanoid; P0CG62; -.
DR   KO; K08770; -.
DR   OMA; VHENTRR; -.
DR   OrthoDB; EOG091G178I; -.
DR   PhylomeDB; P0CG62; -.
DR   Reactome; R-GGA-110312; Translesion synthesis by REV1.
DR   Reactome; R-GGA-110320; Translesion Synthesis by POLH.
DR   Reactome; R-GGA-1169091; Activation of NF-kappaB in B cells.
DR   Reactome; R-GGA-1227882; TRAF mediated activation of IRF.
DR   Reactome; R-GGA-1227888; Negative Regulation of MDA5 signaling.
DR   Reactome; R-GGA-1227892; TRAF6 mediated NF-kB activation.
DR   Reactome; R-GGA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR   Reactome; R-GGA-1253288; Downregulation of ERBB4 signaling.
DR   Reactome; R-GGA-1295596; Spry regulation of FGF signaling.
DR   Reactome; R-GGA-1358803; Downregulation of ERBB2:ERBB3 signaling.
DR   Reactome; R-GGA-168638; NOD1/2 Signaling Pathway.
DR   Reactome; R-GGA-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR   Reactome; R-GGA-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR   Reactome; R-GGA-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR   Reactome; R-GGA-174154; APC/C:Cdc20 mediated degradation of Securin.
DR   Reactome; R-GGA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR   Reactome; R-GGA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; R-GGA-179409; APC-Cdc20 mediated degradation of Nek2A.
DR   Reactome; R-GGA-182971; EGFR downregulation.
DR   Reactome; R-GGA-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-GGA-195253; Degradation of beta-catenin by the destruction complex.
DR   Reactome; R-GGA-201681; TCF dependent signaling in response to WNT.
DR   Reactome; R-GGA-202424; Downstream TCR signaling.
DR   Reactome; R-GGA-209543; p75NTR recruits signalling complexes.
DR   Reactome; R-GGA-209560; NF-kB is activated and signals survival.
DR   Reactome; R-GGA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus.
DR   Reactome; R-GGA-2173788; Downregulation of TGF-beta receptor signaling.
DR   Reactome; R-GGA-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
DR   Reactome; R-GGA-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR   Reactome; R-GGA-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR   Reactome; R-GGA-2467813; Separation of Sister Chromatids.
DR   Reactome; R-GGA-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-GGA-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-GGA-2672351; Stimuli-sensing channels.
DR   Reactome; R-GGA-2871837; FCERI mediated NF-kB activation.
DR   Reactome; R-GGA-3134975; Regulation of innate immune responses to cytosolic DNA.
DR   Reactome; R-GGA-3322077; Glycogen synthesis.
DR   Reactome; R-GGA-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR   Reactome; R-GGA-351465; Fanconi Anemia Pathway in DNA repair.
DR   Reactome; R-GGA-353299; RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases.
DR   Reactome; R-GGA-353303; Nucleotide Excision Repair.
DR   Reactome; R-GGA-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Reactome; R-GGA-382556; ABC-family proteins mediated transport.
DR   Reactome; R-GGA-433822; NFkB and MAPK activation mediated by TRAF6.
DR   Reactome; R-GGA-433871; TRAF6 mediated induction of the anti inflammatory cytokines.
DR   Reactome; R-GGA-434001; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
DR   Reactome; R-GGA-434131; NFkB activation mediated by RIP1 complexed with activated TLR3.
DR   Reactome; R-GGA-437980; Activated TAK1 mediates p38 MAP kinase phosphorylation.
DR   Reactome; R-GGA-437986; Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.
DR   Reactome; R-GGA-446652; Interleukin-1 signaling.
DR   Reactome; R-GGA-450302; activated TAK1 mediates p38 MAPK activation.
DR   Reactome; R-GGA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
DR   Reactome; R-GGA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR   Reactome; R-GGA-4641257; Degradation of AXIN.
DR   Reactome; R-GGA-4641258; Degradation of DVL.
DR   Reactome; R-GGA-4641263; Regulation of FZD by ubiquitination.
DR   Reactome; R-GGA-5205685; Pink/Parkin Mediated Mitophagy.
DR   Reactome; R-GGA-532668; N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
DR   Reactome; R-GGA-5357905; Regulation of TNFR1 signaling.
DR   Reactome; R-GGA-5357956; TNFR1-induced NFkappaB signaling pathway.
DR   Reactome; R-GGA-5358346; Hedgehog ligand biogenesis.
DR   Reactome; R-GGA-5607764; CLEC7A (Dectin-1) signaling.
DR   Reactome; R-GGA-5610780; Degradation of GLI1 by the proteasome.
DR   Reactome; R-GGA-5610785; GLI3 is processed to GLI3R by the proteasome.
DR   Reactome; R-GGA-5632684; Hedgehog 'on' state.
DR   Reactome; R-GGA-5654726; Negative regulation of FGFR1 signaling.
DR   Reactome; R-GGA-5654727; Negative regulation of FGFR2 signaling.
DR   Reactome; R-GGA-5654732; Negative regulation of FGFR3 signaling.
DR   Reactome; R-GGA-5654733; Negative regulation of FGFR4 signaling.
DR   Reactome; R-GGA-5655862; Translesion synthesis by POLK.
DR   Reactome; R-GGA-5656121; Translesion synthesis by POLI.
DR   Reactome; R-GGA-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-GGA-5668541; TNFR2 non-canonical NF-kB pathway.
DR   Reactome; R-GGA-5675221; Negative regulation of MAPK pathway.
DR   Reactome; R-GGA-5675482; Regulation of necroptotic cell death.
DR   Reactome; R-GGA-5684264; MAP3K8 (TPL2)-dependent MAPK1/3 activation.
DR   Reactome; R-GGA-5685942; HDR through Homologous Recombination (HRR).
DR   Reactome; R-GGA-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-GGA-5689603; UCH proteinases.
DR   Reactome; R-GGA-5689877; Josephin domain DUBs.
DR   Reactome; R-GGA-5689880; Ub-specific processing proteases.
DR   Reactome; R-GGA-5689896; Ovarian tumor domain proteases.
DR   Reactome; R-GGA-5689901; Metalloprotease DUBs.
DR   Reactome; R-GGA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR   Reactome; R-GGA-5693607; Processing of DNA double-strand break ends.
DR   Reactome; R-GGA-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-GGA-5696395; Formation of Incision Complex in GG-NER.
DR   Reactome; R-GGA-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER.
DR   Reactome; R-GGA-5696400; Dual Incision in GG-NER.
DR   Reactome; R-GGA-573298; NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation.
DR   Reactome; R-GGA-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-GGA-6782135; Dual incision in TC-NER.
DR   Reactome; R-GGA-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-GGA-6783310; Fanconi Anemia Pathway.
DR   Reactome; R-GGA-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-GGA-6804757; Regulation of TP53 Degradation.
DR   Reactome; R-GGA-6804760; Regulation of TP53 Activity through Methylation.
DR   Reactome; R-GGA-6807004; Negative regulation of MET activity.
DR   Reactome; R-GGA-68827; CDT1 association with the CDC6:ORC:origin complex.
DR   Reactome; R-GGA-68949; Orc1 removal from chromatin.
DR   Reactome; R-GGA-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-GGA-69229; Ubiquitin-dependent degradation of Cyclin D1.
DR   Reactome; R-GGA-69231; Cyclin D associated events in G1.
DR   Reactome; R-GGA-69298; Association of licensing factors with the pre-replicative complex.
DR   Reactome; R-GGA-69541; Stabilization of p53.
DR   Reactome; R-GGA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR   Reactome; R-GGA-8849469; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
DR   Reactome; R-GGA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR   Reactome; R-GGA-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-GGA-8856828; Clathrin-mediated endocytosis.
DR   Reactome; R-GGA-8863795; Downregulation of ERBB2 signaling.
DR   Reactome; R-GGA-8866652; Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
DR   Reactome; R-GGA-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Reactome; R-GGA-8941858; Regulation of RUNX3 expression and activity.
DR   Reactome; R-GGA-8951664; Neddylation.
DR   Reactome; R-GGA-901032; ER Quality Control Compartment (ERQC).
DR   Reactome; R-GGA-912631; Regulation of signaling by CBL.
DR   Reactome; R-GGA-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   Reactome; R-GGA-917937; Iron uptake and transport.
DR   Reactome; R-GGA-937042; IRAK2 mediated activation of TAK1 complex.
DR   Reactome; R-GGA-937072; TRAF6 mediated induction of TAK1 complex.
DR   Reactome; R-GGA-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
DR   Reactome; R-GGA-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
DR   Reactome; R-GGA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:P0CG62; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000004509; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0006281; P:DNA repair; TAS:Reactome.
DR   GO; GO:0019985; P:translesion synthesis; TAS:Reactome.
DR   InterPro; IPR019956; Ubiquitin.
DR   InterPro; IPR029071; Ubiquitin-rel_dom.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR000626; Ubiquitin_dom.
DR   Pfam; PF00240; ubiquitin; 4.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 4.
DR   SUPFAM; SSF54236; SSF54236; 4.
DR   PROSITE; PS00299; UBIQUITIN_1; 4.
DR   PROSITE; PS50053; UBIQUITIN_2; 4.
PE   2: Evidence at transcript level;
DR   PRODOM; P0CG62.
DR   SWISS-2DPAGE; P0CG62.
KW   Complete proteome; Cytoplasm; Isopeptide bond; Nucleus;
KW   Reference proteome; Repeat; Ubl conjugation.
FT   CHAIN         1     76       Ubiquitin.
FT                                /FTId=PRO_0000114808.
FT   CHAIN        77    152       Ubiquitin.
FT                                /FTId=PRO_0000396246.
FT   CHAIN       153    228       Ubiquitin.
FT                                /FTId=PRO_0000396247.
FT   CHAIN       229    304       Ubiquitin.
FT                                /FTId=PRO_0000396248.
FT   PROPEP      305    305
FT                                /FTId=PRO_0000396249.
FT   DOMAIN        1     76       Ubiquitin-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00214}.
FT   DOMAIN       77    152       Ubiquitin-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00214}.
FT   DOMAIN      153    228       Ubiquitin-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00214}.
FT   DOMAIN      229    304       Ubiquitin-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00214}.
FT   BINDING      54     54       Activating enzyme.
FT   BINDING      72     72       Activating enzyme.
FT   SITE         68     68       Essential for function.
FT   CROSSLNK      6      6       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     11     11       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     27     27       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     29     29       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     33     33       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     48     48       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     63     63       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     76     76       Glycyl lysine isopeptide (Gly-Lys)
FT                                (interchain with K-? in acceptor
FT                                proteins). {ECO:0000255|PROSITE-
FT                                ProRule:PRU00214}.
FT   CONFLICT    149    149       L -> M (in Ref. 2; CAA26488).
FT                                {ECO:0000305}.
FT   CONFLICT    271    271       L -> W (in Ref. 2; CAA26488).
FT                                {ECO:0000305}.
SQ   SEQUENCE   305 AA;  34369 MW;  0B8C7878AE958E68 CRC64;
     MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
     IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI
     FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA
     KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT
     ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR
     LRGGY
//

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