(data stored in ACNUC16935 zone)


ID   RL40_CHICK              Reviewed;          69 AA.
AC   P62985; P02248; P02249; P02250; P14793; P62973; Q29120; Q91887;
AC   Q91888;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 2.
DT   08-MAY-2019, entry version 73.
DE   RecName: Full=Ubiquitin-60S ribosomal protein L40;
DE   AltName: Full=Ubiquitin A-52 residue ribosomal protein fusion product 1;
DE   Contains:
DE     RecName: Full=Ubiquitin;
DE   Contains:
DE     RecName: Full=60S ribosomal protein L40;
DE     AltName: Full=CEP52;
DE   Flags: Precursor; Fragment;
GN   Name=UBA52; Synonyms=UBCEP2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RC   TISSUE=Spermatid;
RX   PubMed=2850543; DOI=10.1093/nar/16.24.11838;
RA   Mezquita J., Pau M., Mezquita C.;
RT   "cDNA encoding a chicken ubiquitin-fusion protein identical to the
RT   corresponding human protein.";
RL   Nucleic Acids Res. 16:11838-11838(1988).
CC   -!- FUNCTION: Ubiquitin: exists either covalently attached to another
CC       protein, or free (unanchored). When covalently bound, it is
CC       conjugated to target proteins via an isopeptide bond either as a
CC       monomer (monoubiquitin), a polymer linked via different Lys
CC       residues of the ubiquitin (polyubiquitin chains) or a linear
CC       polymer linked via the initiator Met of the ubiquitin (linear
CC       polyubiquitin chains). Polyubiquitin chains, when attached to a
CC       target protein, have different functions depending on the Lys
CC       residue of the ubiquitin that is linked: Lys-6-linked may be
CC       involved in DNA repair; Lys-11-linked is involved in ERAD
CC       (endoplasmic reticulum-associated degradation) and in cell-cycle
CC       regulation; Lys-29-linked is involved in lysosomal degradation;
CC       Lys-33-linked is involved in kinase modification; Lys-48-linked is
CC       involved in protein degradation via the proteasome; Lys-63-linked
CC       is involved in endocytosis, DNA-damage responses as well as in
CC       signaling processes leading to activation of the transcription
CC       factor NF-kappa-B. Linear polymer chains formed via attachment by
CC       the initiator Met lead to cell signaling. Ubiquitin is usually
CC       conjugated to Lys residues of target proteins, however, in rare
CC       cases, conjugation to Cys or Ser residues has been observed. When
CC       polyubiquitin is free (unanchored-polyubiquitin), it also has
CC       distinct roles, such as in activation of protein kinases, and in
CC       signaling (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: 60S ribosomal protein L40: component of the 60S subunit
CC       of the ribosome. {ECO:0000250}.
CC   -!- SUBUNIT: Ribosomal protein L40 is part of the 60S ribosomal
CC       subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: 60S ribosomal protein L40: Cytoplasm
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Ubiquitin is encoded by 4 different genes. Uba52
CC       and Rps27a genes code for a single copy of ubiquitin fused to the
CC       ribosomal proteins L40 and S27a, respectively. UBB and UBC genes
CC       code for a polyubiquitin precursor with exact head to tail
CC       repeats, the number of repeats differ between species and strains.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the ubiquitin
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the eukaryotic
CC       ribosomal protein eL40 family. {ECO:0000305}.
DR   EMBL; X13493; CAA31848.1; -; mRNA.
DR   SMR; P62985; -.
DR   PRIDE; P62985; -.
DR   InParanoid; P62985; -.
DR   OrthoDB; 1536766at2759; -.
DR   PhylomeDB; P62985; -.
DR   Reactome; R-GGA-1227882; TRAF mediated activation of IRF.
DR   Reactome; R-GGA-1227888; Negative Regulation of MDA5 signaling.
DR   Reactome; R-GGA-1227892; TRAF6 mediated NF-kB activation.
DR   Reactome; R-GGA-351465; Fanconi Anemia Pathway in DNA repair.
DR   Reactome; R-GGA-353299; RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases.
DR   Reactome; R-GGA-353303; Nucleotide Excision Repair.
DR   Reactome; R-GGA-433822; NFkB and MAPK activation mediated by TRAF6.
DR   Reactome; R-GGA-433871; TRAF6 mediated induction of proinflammatory cytokines.
DR   Reactome; R-GGA-434001; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
DR   Reactome; R-GGA-434131; NFkB activation mediated by RIP1 complexed with activated TLR3.
DR   Reactome; R-GGA-437980; Activated TAK1 mediates p38 MAP kinase phosphorylation.
DR   Reactome; R-GGA-437986; Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.
DR   Reactome; R-GGA-573298; NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; TAS:Reactome.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D;; -; 1.
DR   InterPro; IPR038587; L40e_sf.
DR   InterPro; IPR001975; Ribosomal_L40e.
DR   InterPro; IPR011332; Ribosomal_zn-bd.
DR   Pfam; PF01020; Ribosomal_L40e; 1.
DR   SMART; SM01377; Ribosomal_L40e; 1.
DR   SUPFAM; SSF57829; SSF57829; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q91888.
DR   SWISS-2DPAGE; Q91888.
KW   Complete proteome; Cytoplasm; Isopeptide bond; Methylation; Nucleus;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   Ubl conjugation.
FT   CHAIN        <1     17       Ubiquitin.
FT                                /FTId=PRO_0000396441.
FT   CHAIN        18     69       60S ribosomal protein L40.
FT                                /FTId=PRO_0000138755.
FT   DOMAIN       <1     17       Ubiquitin-like.
FT   BINDING      13     13       Activating enzyme.
FT   SITE          9      9       Essential for function.
FT   MOD_RES      39     39       N6,N6,N6-trimethyllysine. {ECO:0000250}.
FT   CROSSLNK      4      4       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250}.
FT   CROSSLNK     17     17       Glycyl lysine isopeptide (Gly-Lys)
FT                                (interchain with K-? in acceptor
FT                                proteins). {ECO:0000250}.
FT   NON_TER       1      1
SQ   SEQUENCE   69 AA;  8098 MW;  7ABF8DDDE660A429 CRC64;

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