(data stored in ACNUC7421 zone)

SWISSPROT: ILVH_SALTY

ID   ILVH_SALTY              Reviewed;         163 AA.
AC   P21622; Q9JP76;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   11-DEC-2019, entry version 131.
DE   RecName: Full=Acetolactate synthase isozyme 3 small subunit;
DE            EC=2.2.1.6;
DE   AltName: Full=ALS-III;
DE   AltName: Full=Acetohydroxy-acid synthase III small subunit;
DE            Short=AHAS-III;
GN   Name=ilvH; OrderedLocusNames=STM0117;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=1851954; DOI=10.1007/bf00273623;
RA   Jahreis K., Postma P.W., Lengeler J.W.;
RT   "Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12
RT   and Salmonella typhimurium LT2.";
RL   Mol. Gen. Genet. 226:332-336(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RA   El Hanafi D., Maloriol D., Figueroa-Bossi N., Bossi L.;
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2;
CC         Xref=Rhea:RHEA:25249, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58476; EC=2.2.1.6;
CC   -!- ACTIVITY REGULATION: Sensitive to valine inhibition.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from
CC       pyruvate: step 1/4.
CC   -!- SUBUNIT: Dimer of large and small chains.
CC   -!- MISCELLANEOUS: S.typhimurium contains genes for 3 AHAS isozymes: ilvBN,
CC       ilvGM and ilvIH.
CC   -!- SIMILARITY: Belongs to the acetolactate synthase small subunit family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF65177.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; X55456; CAA39102.1; -; Genomic_DNA.
DR   EMBL; AF117227; AAF65177.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE006468; AAL19081.1; -; Genomic_DNA.
DR   PIR; S15940; S15940.
DR   RefSeq; NP_459122.1; NC_003197.2.
DR   RefSeq; WP_001563086.1; NC_003197.2.
DR   SMR; P21622; -.
DR   PaxDb; P21622; -.
DR   PRIDE; P21622; -.
DR   EnsemblBacteria; AAL19081; AAL19081; STM0117.
DR   GeneID; 1251635; -.
DR   KEGG; stm:STM0117; -.
DR   PATRIC; fig|99287.12.peg.122; -.
DR   eggNOG; ENOG4108ZP8; Bacteria.
DR   eggNOG; COG0440; LUCA.
DR   HOGENOM; HOG000046747; -.
DR   KO; K01653; -.
DR   OMA; EHPDISR; -.
DR   PhylomeDB; P21622; -.
DR   BioCyc; SENT99287:STM0117-MONOMER; -.
DR   UniPathway; UPA00047; UER00055.
DR   UniPathway; UPA00049; UER00059.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005948; C:acetolactate synthase complex; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003984; F:acetolactate synthase activity; IBA:GO_Central.
DR   GO; GO:1990610; F:acetolactate synthase regulator activity; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009099; P:valine biosynthetic process; IBA:GO_Central.
DR   CDD; cd04878; ACT_AHAS; 1.
DR   Gene3D; 3.30.70.1150; -; 1.
DR   InterPro; IPR004789; Acetalactate_synth_ssu.
DR   InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR   InterPro; IPR019455; Acetolactate_synth_ssu_C.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR039557; AHAS_ACT.
DR   PANTHER; PTHR30239; PTHR30239; 1.
DR   Pfam; PF10369; ALS_ss_C; 1.
DR   TIGRFAMs; TIGR00119; acolac_sm; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   3: Inferred from homology;
DR   PRODOM; P21622.
DR   SWISS-2DPAGE; P21622.
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Reference proteome; Transferase.
FT   CHAIN           1..163
FT                   /note="Acetolactate synthase isozyme 3 small subunit"
FT                   /id="PRO_0000151411"
FT   DOMAIN          4..78
FT                   /note="ACT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT   CONFLICT        91..92
FT                   /note="IQ -> ME (in Ref. 1; CAA39102)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   163 AA;  18063 MW;  82066840D433D6B5 CRC64;
     MRRILSVLLE NESGALSRVI GLFSQRGYNI ESLTVAPTDD PTLSRMTIQT VGDEKVLEQI
     EKQLHKLVDV LRVSELGQGA HVEREIMLVK IQASGYGREE VKRNTEIFRG QIIDVTPTLY
     TVQLAGTSDK LDAFLASLRD VAKIVEVARS GVVGLSRGDK IMR
//

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