(data stored in SCRATCH zone)

SWISSPROT: HOLB_BACSU

ID   HOLB_BACSU              Reviewed;         329 AA.
AC   P37540;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   11-DEC-2019, entry version 116.
DE   RecName: Full=DNA polymerase III subunit delta';
DE            EC=2.7.7.7;
GN   Name=holB; Synonyms=yaaS; OrderedLocusNames=BSU00310;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7584024; DOI=10.1093/dnares/1.1.1;
RA   Ogasawara N., Nakai S., Yoshikawa H.;
RT   "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis
RT   chromosome containing the replication origin.";
RL   DNA Res. 1:1-14(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130,
CC         Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:83828; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
DR   EMBL; D26185; BAA05267.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB11807.1; -; Genomic_DNA.
DR   PIR; S66061; S66061.
DR   RefSeq; NP_387912.1; NC_000964.3.
DR   RefSeq; WP_003244417.1; NZ_JNCM01000028.1.
DR   SMR; P37540; -.
DR   IntAct; P37540; 2.
DR   STRING; 224308.BSU00310; -.
DR   PaxDb; P37540; -.
DR   PRIDE; P37540; -.
DR   EnsemblBacteria; CAB11807; CAB11807; BSU00310.
DR   GeneID; 935949; -.
DR   KEGG; bsu:BSU00310; -.
DR   PATRIC; fig|224308.179.peg.31; -.
DR   eggNOG; ENOG4105FA2; Bacteria.
DR   eggNOG; COG0470; LUCA.
DR   HOGENOM; HOG000192593; -.
DR   InParanoid; P37540; -.
DR   KO; K02341; -.
DR   OMA; HAYIFEG; -.
DR   PhylomeDB; P37540; -.
DR   BioCyc; BSUB:BSU00310-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IBA:GO_Central.
DR   InterPro; IPR004622; DNA_pol_HolB.
DR   InterPro; IPR015199; DNA_pol_III_delta_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF09115; DNApol3-delta_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00678; holB; 1.
PE   3: Inferred from homology;
DR   PRODOM; P37540.
DR   SWISS-2DPAGE; P37540.
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..329
FT                   /note="DNA polymerase III subunit delta'"
FT                   /id="PRO_0000105509"
SQ   SEQUENCE   329 AA;  37621 MW;  23F97A1E11FA22E5 CRC64;
     MAISWKEMNE LQPRVMKLLY NSIEKDRLSH AYLFEGKKGT GKLDAALLLA KSFFCLEGGA
     EPCESCRNCK RIESGNHPDL HLVQPDGLSI KKAQIQALQE EFSKTGLESH KKLYIISHAD
     QMTANAANSL LKFLEEPNKD TMAVLITEQP QRLLDTIISR CQTLPFQPLQ PKAIEDRLIE
     QDVSPHMARL LANMTNNVAE AVELSRNDEF AESRAKVIKL YEVLHQRKGH AFFFIQDQWM
     PFFKEKTHQE MGLDMLLLIY RDVLSIQIGN EDKLIYQDLF QSIKQHALQS TQQSVTNQIL
     AVLEAKKRLH SNVNVQGLME HLVLMLQEG
//

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