(data stored in ACNUC7421 zone)

SWISSPROT: FEUC_BACSU

ID   FEUC_BACSU              Reviewed;         336 AA.
AC   P40411;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 3.
DT   11-DEC-2019, entry version 130.
DE   RecName: Full=Iron-uptake system permease protein FeuC;
GN   Name=feuC; OrderedLocusNames=BSU01610;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9274029; DOI=10.1099/00221287-143-8-2763;
RA   Liu H., Haga K., Yasumoto K., Ohashi Y., Yoshikawa H., Takahashi H.;
RT   "Sequence and analysis of a 31 kb segment of the Bacillus subtilis
RT   chromosome in the area of the rrnH and rrnG operons.";
RL   Microbiology 143:2763-2767(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO C-TERMINUS.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-87.
RC   STRAIN=BD99 / MS94;
RX   PubMed=8011666; DOI=10.1016/0005-2728(94)90131-7;
RA   Quirk P.G., Guffanti A.A., Clejan S., Cheng J., Krulwich T.A.;
RT   "Isolation of Tn917 insertional mutants of Bacillus subtilis that are
RT   resistant to the protonophore carbonyl cyanide m-chlorophenylhydrazone.";
RL   Biochim. Biophys. Acta 1186:27-34(1994).
RN   [5]
RP   FUNCTION, AND POSSIBLE SUBUNIT.
RC   STRAIN=168;
RX   PubMed=16672620; DOI=10.1128/jb.188.10.3664-3673.2006;
RA   Ollinger J., Song K.-B., Antelmann H., Hecker M., Helmann J.D.;
RT   "Role of the Fur regulon in iron transport in Bacillus subtilis.";
RL   J. Bacteriol. 188:3664-3673(2006).
RN   [6]
RP   INDUCTION.
RC   STRAIN=168 / CU1065;
RX   PubMed=17725565; DOI=10.1111/j.1365-2958.2007.05905.x;
RA   Gaballa A., Helmann J.D.;
RT   "Substrate induction of siderophore transport in Bacillus subtilis mediated
RT   by a novel one-component regulator.";
RL   Mol. Microbiol. 66:164-173(2007).
CC   -!- FUNCTION: Involved in the uptake of iron. Probably responsible for the
CC       translocation of the substrate across the membrane.
CC       {ECO:0000269|PubMed:16672620}.
CC   -!- FUNCTION: Part of the ABC transporter complex FeuABC/YusV involved in
CC       import of the catecholate siderophores bacillibactin and enterobactin.
CC       {ECO:0000305|PubMed:16672620}.
CC   -!- SUBUNIT: The complex is composed of one ATP-binding protein (YusV), two
CC       transmembrane proteins (FeuB and FeuC) and a solute-binding protein
CC       (FeuA). {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: Induced by Btr in iron-limited conditions.
CC       {ECO:0000269|PubMed:17725565}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA12262.1; Type=Frameshift; Evidence={ECO:0000305};
DR   EMBL; D84213; BAA12262.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL009126; CAB11937.2; -; Genomic_DNA.
DR   EMBL; L19954; AAA64356.1; -; Genomic_DNA.
DR   PIR; G69621; G69621.
DR   RefSeq; NP_388042.2; NC_000964.3.
DR   RefSeq; WP_003234980.1; NZ_JNCM01000030.1.
DR   STRING; 224308.BSU01610; -.
DR   TCDB; 3.A.1.14.15; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P40411; -.
DR   PRIDE; P40411; -.
DR   EnsemblBacteria; CAB11937; CAB11937; BSU01610.
DR   GeneID; 938893; -.
DR   KEGG; bsu:BSU01610; -.
DR   PATRIC; fig|224308.179.peg.167; -.
DR   eggNOG; COG0609; LUCA.
DR   HOGENOM; HOG000045409; -.
DR   InParanoid; P40411; -.
DR   KO; K02015; -.
DR   OMA; SIYNANW; -.
DR   PhylomeDB; P40411; -.
DR   BioCyc; BSUB:BSU01610-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0033214; P:siderophore-dependent iron import into cell; IBA:GO_Central.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P40411.
DR   SWISS-2DPAGE; P40411.
KW   Cell membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..336
FT                   /note="Iron-uptake system permease protein FeuC"
FT                   /id="PRO_0000060025"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   336 AA;  36090 MW;  DF398006A6425F0F CRC64;
     MAKKYALFIA LILVVSYFSL TSGSFSVRPA ELLSTLFQID PNPQYEILLF DLRLPRVVMA
     AIIGLGLGIA GAVIQAITRN GLADPGILGI NAGAGAGIVA FMLLFQGQKE VTSIAAAMGM
     PLFGLIGGLI AAILIYIFAW HRGNLDSGRI ILVGIAINSG FSALSLFLSL KMDPQDYQMA
     MVWKNGSIWS ANWTYITAVL PWMLLFIPIL IGKSRLLDTI RFDEDTVRSL GISSNKEKTI
     LLVACVAIIS ACVSVAGSMA FVGLIAPHIS RRLAGVEHRY ILPLSGLIGM LLVISADFAG
     KLFFQPAEVP AGIILAILGV PYFLYLLFKQ KKGENA
//

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