(data stored in ACNUC7421 zone)

SWISSPROT: FEUB_BACSU

ID   FEUB_BACSU              Reviewed;         334 AA.
AC   P40410;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   11-DEC-2019, entry version 123.
DE   RecName: Full=Iron-uptake system permease protein FeuB;
GN   Name=feuB; OrderedLocusNames=BSU01620;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BD99 / MS94;
RX   PubMed=8011666; DOI=10.1016/0005-2728(94)90131-7;
RA   Quirk P.G., Guffanti A.A., Clejan S., Cheng J., Krulwich T.A.;
RT   "Isolation of Tn917 insertional mutants of Bacillus subtilis that are
RT   resistant to the protonophore carbonyl cyanide m-chlorophenylhydrazone.";
RL   Biochim. Biophys. Acta 1186:27-34(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9274029; DOI=10.1099/00221287-143-8-2763;
RA   Liu H., Haga K., Yasumoto K., Ohashi Y., Yoshikawa H., Takahashi H.;
RT   "Sequence and analysis of a 31 kb segment of the Bacillus subtilis
RT   chromosome in the area of the rrnH and rrnG operons.";
RL   Microbiology 143:2763-2767(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   FUNCTION, AND POSSIBLE SUBUNIT.
RC   STRAIN=168;
RX   PubMed=16672620; DOI=10.1128/jb.188.10.3664-3673.2006;
RA   Ollinger J., Song K.-B., Antelmann H., Hecker M., Helmann J.D.;
RT   "Role of the Fur regulon in iron transport in Bacillus subtilis.";
RL   J. Bacteriol. 188:3664-3673(2006).
RN   [5]
RP   INDUCTION.
RC   STRAIN=168 / CU1065;
RX   PubMed=17725565; DOI=10.1111/j.1365-2958.2007.05905.x;
RA   Gaballa A., Helmann J.D.;
RT   "Substrate induction of siderophore transport in Bacillus subtilis mediated
RT   by a novel one-component regulator.";
RL   Mol. Microbiol. 66:164-173(2007).
CC   -!- FUNCTION: Involved in the uptake of iron. Probably responsible for the
CC       translocation of the substrate across the membrane.
CC       {ECO:0000269|PubMed:16672620}.
CC   -!- FUNCTION: Part of the ABC transporter complex FeuABC/YusV involved in
CC       import of the catecholate siderophores bacillibactin and enterobactin.
CC       {ECO:0000305|PubMed:16672620}.
CC   -!- SUBUNIT: The complex is composed of one ATP-binding protein (YusV), two
CC       transmembrane proteins (FeuB and FeuC) and a solute-binding protein
CC       (FeuA). {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: Induced by Btr in iron-limited conditions.
CC       {ECO:0000269|PubMed:17725565}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000305}.
DR   EMBL; L19954; AAA64355.1; -; Genomic_DNA.
DR   EMBL; AB002150; BAA19495.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB11938.1; -; Genomic_DNA.
DR   PIR; I39843; I39843.
DR   RefSeq; NP_388043.1; NC_000964.3.
DR   RefSeq; WP_003234979.1; NZ_JNCM01000030.1.
DR   SMR; P40410; -.
DR   STRING; 224308.BSU01620; -.
DR   TCDB; 3.A.1.14.15; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P40410; -.
DR   PRIDE; P40410; -.
DR   EnsemblBacteria; CAB11938; CAB11938; BSU01620.
DR   GeneID; 938884; -.
DR   KEGG; bsu:BSU01620; -.
DR   PATRIC; fig|224308.179.peg.168; -.
DR   eggNOG; COG0609; LUCA.
DR   HOGENOM; HOG000045410; -.
DR   InParanoid; P40410; -.
DR   KO; K02015; -.
DR   OMA; WYSARLH; -.
DR   PhylomeDB; P40410; -.
DR   BioCyc; BSUB:BSU01620-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEP:CACAO.
DR   GO; GO:0033214; P:siderophore-dependent iron import into cell; IBA:GO_Central.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P40410.
DR   SWISS-2DPAGE; P40410.
KW   Cell membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..334
FT                   /note="Iron-uptake system permease protein FeuB"
FT                   /id="PRO_0000060024"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   334 AA;  35897 MW;  5FD4CF983E51D9E3 CRC64;
     MYSKQWTRII LITSPFAIAL SLLLSILYGA KHLSTDIVFT SLIHFDPGNT DHQIIWHSRI
     PRAAGALLIG AALAVSGALM QGITRNYLAS PSIMGVSDGS AFIITLCMVL LPQSSSIEMM
     IYSFIGSALG AVLVFGLAAM MPNGFTPVQL AIIGTVTSML LSSLSAAMSI YFQISQDLSF
     WYSARLHQMS PDFLKLAAPF FLIGIIMAIS LSKKVTAVSL GDDISKSLGQ KKKTIKIMAM
     LSVIILTGSA VALAGKIAFV GLVVPHITRF LVGSDYSRLI PCSCILGGIF LTLCDLASRF
     INYPFETPIE VVTSIIGVPF FLYLIKRKGG EQNG
//

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