(data stored in ACNUC7421 zone)

SWISSPROT: PSS_BACSU

ID   PSS_BACSU               Reviewed;         177 AA.
AC   P39823;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   11-DEC-2019, entry version 122.
DE   RecName: Full=CDP-diacylglycerol--serine O-phosphatidyltransferase;
DE            EC=2.7.8.8;
DE   AltName: Full=Phosphatidylserine synthase;
GN   Name=pssA; Synonyms=pss; OrderedLocusNames=BSU02270;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / VKM B-501;
RX   PubMed=8002567; DOI=10.1128/jb.176.24.7456-7461.1994;
RA   Okada M., Matsuzaki H., Shibuya I., Matsumoto K.;
RT   "Cloning, sequencing, and expression in Escherichia coli of the Bacillus
RT   subtilis gene for phosphatidylserine synthase.";
RL   J. Bacteriol. 176:7456-7461(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Haga K., Liu H., Yasumoto K., Takahashi H., Yoshikawa H.;
RT   "Sequence analysis of the 70kb region between 17 and 23 degree of the
RT   Bacillus subtilis chromosome.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + L-serine = 1,2-diacyl-sn-
CC         glycero-3-phospho-L-serine + CMP + H(+); Xref=Rhea:RHEA:16913,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33384, ChEBI:CHEBI:57262,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.8;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000305}.
DR   EMBL; D38022; BAA07225.1; -; Genomic_DNA.
DR   EMBL; AB006424; BAA33124.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12021.1; -; Genomic_DNA.
DR   PIR; A55537; A55537.
DR   RefSeq; NP_388109.1; NC_000964.3.
DR   RefSeq; WP_009966430.1; NZ_JNCM01000030.1.
DR   SMR; P39823; -.
DR   STRING; 224308.BSU02270; -.
DR   PaxDb; P39823; -.
DR   PRIDE; P39823; -.
DR   DNASU; 938427; -.
DR   EnsemblBacteria; CAB12021; CAB12021; BSU02270.
DR   GeneID; 938427; -.
DR   KEGG; bsu:BSU02270; -.
DR   PATRIC; fig|224308.179.peg.233; -.
DR   eggNOG; ENOG4106PT6; Bacteria.
DR   eggNOG; COG1183; LUCA.
DR   HOGENOM; HOG000229370; -.
DR   InParanoid; P39823; -.
DR   KO; K17103; -.
DR   OMA; YSICGML; -.
DR   PhylomeDB; P39823; -.
DR   BioCyc; BSUB:BSU02270-MONOMER; -.
DR   BioCyc; MetaCyc:MONOMER-14512; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004533; CDP-diaglyc--ser_O-PTrfase.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   TIGRFAMs; TIGR00473; pssA; 1.
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE   3: Inferred from homology;
DR   PRODOM; P39823.
DR   SWISS-2DPAGE; P39823.
KW   Cell membrane; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..177
FT                   /note="CDP-diacylglycerol--serine O-
FT                   phosphatidyltransferase"
FT                   /id="PRO_0000056793"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   177 AA;  19613 MW;  55CFCDF1F3C18EE8 CRC64;
     MNYIPCMITI GNFICGLLAI HSLLYHNIHS AVLFIFTGMF LDFFDGMAAR KLNAVSDMGR
     ELDSFADLVT FGVAPSMLAY SVALYTLPFI GILCALTYSI CGMLRLSKFN IEQSKLPTFI
     GMPIPFAGMC LVILSFTYNP ILLAIGTCGL SYLMVSKIKF PHFKKHAAEN LESGRWN
//

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