(data stored in ACNUC7421 zone)

SWISSPROT: GAMR_BACSU

ID   GAMR_BACSU              Reviewed;         235 AA.
AC   O31459; Q7DL45;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   11-DEC-2019, entry version 111.
DE   RecName: Full=HTH-type transcriptional repressor GamR {ECO:0000305};
GN   Name=gamR {ECO:0000303|PubMed:24673833}; Synonyms=ybgA;
GN   OrderedLocusNames=BSU02370;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Haga K., Liu H., Yasumoto K., Takahashi H., Yoshikawa H.;
RT   "Sequence analysis of the 70kb region between 17 and 23 degree of the
RT   Bacillus subtilis chromosome.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION, DNA-BINDING, AND ACTIVITY REGULATION.
RX   PubMed=24673833; DOI=10.1111/mmi.12544;
RA   Gaugue I., Oberto J., Plumbridge J.;
RT   "Regulation of amino sugar utilization in Bacillus subtilis by the GntR
RT   family regulators, NagR and GamR.";
RL   Mol. Microbiol. 92:100-115(2014).
CC   -!- FUNCTION: Transcriptional repressor of genes involved in glucosamine
CC       transport and utilization. Represses the expression of the gamAP operon
CC       by binding to the gamA-gamR intergenic region.
CC       {ECO:0000269|PubMed:24673833}.
CC   -!- ACTIVITY REGULATION: Binding to DNA is allosterically inhibited by the
CC       effector glucosamine-6-phosphate (GlcN6P). N-acetylglucosamine-6-
CC       phosphate (GlcNAc6P) and glucose-6-phosphate (Glc6P) have no effect.
CC       {ECO:0000269|PubMed:24673833}.
DR   EMBL; AB006424; BAA33134.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12031.1; -; Genomic_DNA.
DR   PIR; F69750; F69750.
DR   RefSeq; NP_388119.1; NC_000964.3.
DR   RefSeq; WP_003234841.1; NZ_JNCM01000030.1.
DR   SMR; O31459; -.
DR   STRING; 224308.BSU02370; -.
DR   PaxDb; O31459; -.
DR   PRIDE; O31459; -.
DR   EnsemblBacteria; CAB12031; CAB12031; BSU02370.
DR   GeneID; 938422; -.
DR   KEGG; bsu:BSU02370; -.
DR   PATRIC; fig|224308.179.peg.243; -.
DR   eggNOG; ENOG4108X79; Bacteria.
DR   eggNOG; ENOG4111JSC; LUCA.
DR   HOGENOM; HOG000228717; -.
DR   InParanoid; O31459; -.
DR   KO; K03710; -.
DR   OMA; EWKPGEM; -.
DR   PhylomeDB; O31459; -.
DR   BioCyc; BSUB:BSU02370-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   1: Evidence at protein level;
DR   PRODOM; O31459.
DR   SWISS-2DPAGE; O31459.
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..235
FT                   /note="HTH-type transcriptional repressor GamR"
FT                   /id="PRO_0000360573"
FT   DOMAIN          2..70
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        30..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   235 AA;  26603 MW;  E7AFB934DD2FE570 CRC64;
     MTALYSVIKF KIIELIKSGK YQANDQLPTE SEFCEQYDVS RTTVRLALQQ LELEGYIKRI
     QGKGTFVSAA KIQTPIPHKI TSFAEQMRGL RSESKVLELV VIPADHSIAE LLKMKENEPV
     NKLVRVRYAE GEPLQYHTSY IPWKAAPGLA QEECTGSLFE LLRTKYNIEI SRGTESIEPI
     LTDETISGHL LTNVGAPAFL SESLTYDKNE EVVEYAQIIT RGDRTKFTVE QSYHS
//

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