(data stored in SCRATCH zone)

SWISSPROT: GUDP_BACSU

ID   GUDP_BACSU              Reviewed;         455 AA.
AC   P42237;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   11-DEC-2019, entry version 118.
DE   RecName: Full=Probable glucarate transporter;
DE   AltName: Full=D-glucarate permease;
GN   Name=gudP; Synonyms=ycbE; OrderedLocusNames=BSU02480;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7704254; DOI=10.1099/13500872-141-2-269;
RA   Ogawa K., Akagawa E., Nakamura K., Yamane K.;
RT   "Determination of a 21548 bp nucleotide sequence around the 24 degrees
RT   region of the Bacillus subtilis chromosome.";
RL   Microbiology 141:269-275(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 167.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
CC   -!- FUNCTION: Uptake of D-glucarate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Phthalate
CC       permease family. {ECO:0000305}.
DR   EMBL; D30808; BAA06469.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12042.2; -; Genomic_DNA.
DR   PIR; H69752; H69752.
DR   RefSeq; NP_388130.2; NC_000964.3.
DR   RefSeq; WP_003234818.1; NZ_JNCM01000030.1.
DR   STRING; 224308.BSU02480; -.
DR   TCDB; 2.A.1.14.1; the major facilitator superfamily (mfs).
DR   PaxDb; P42237; -.
DR   PRIDE; P42237; -.
DR   EnsemblBacteria; CAB12042; CAB12042; BSU02480.
DR   GeneID; 938413; -.
DR   KEGG; bsu:BSU02480; -.
DR   PATRIC; fig|224308.179.peg.255; -.
DR   eggNOG; ENOG4105DJB; Bacteria.
DR   eggNOG; ENOG410XPWC; LUCA.
DR   HOGENOM; HOG000113642; -.
DR   InParanoid; P42237; -.
DR   KO; K03535; -.
DR   OMA; CGVPKRY; -.
DR   PhylomeDB; P42237; -.
DR   BioCyc; BSUB:BSU02480-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 2.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; P42237.
DR   SWISS-2DPAGE; P42237.
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..455
FT                   /note="Probable glucarate transporter"
FT                   /id="PRO_0000121384"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        167
FT                   /note="S -> P (in Ref. 1; BAA06469)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   455 AA;  49244 MW;  A069905BC7922757 CRC64;
     MKKDFASVTP AGKKTSVRWF IVFMLFLVTS INYADRATLS ITGDSVQHDL GLDSVAMGYV
     FSAFGWAYVI GQLPGGWLLD RFGSKTIIAL SIFFWSFFTL LQGAIGFFSA GTAIILLFAL
     RFLVGLSEAP SFPGNGRVVA SWFPSSERGT ASAFFNSAQY FAIVIFSPLM GWLTHSFGWH
     SVFVVMGIAG ILLAVIWLKT VYEPKKHPKV NEAELAYIEQ GGGLISMDDS KSKQETESKW
     PYIKQLLTNR MLIGVYIAQY CITTLTYFFL TWFPVYLVQA RGMSILEAGF VASLPALCGF
     AGGVLGGIVS DILLKKGRSL TFARKVPIIA GMLLSCSMIV CNYTDSAWLV VVIMSLAFFG
     KGFGALGWAV VSDTSPKECA GLSGGLFNTF GNIASITTPI IIGYIVNATG SFNGALVFVG
     ANAIAAILSY LLLVGPIKRV VLKKQEQDPD QSLPV
//

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