(data stored in ACNUC7421 zone)

SWISSPROT: LMRA_BACSU

ID   LMRA_BACSU              Reviewed;         188 AA.
AC   O34619; Q797R9;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   11-DEC-2019, entry version 117.
DE   RecName: Full=HTH-type transcriptional regulator LmrA;
GN   Name=lmrA; Synonyms=yccB; OrderedLocusNames=BSU02680;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9274031; DOI=10.1099/00221287-143-8-2775;
RA   Kumano M., Tamakoshi A., Yamane K.;
RT   "A 32 kb nucleotide sequence from the region of the lincomycin-resistance
RT   gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and
RT   identification of the site of the lin-2 mutation.";
RL   Microbiology 143:2775-2782(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RX   PubMed=12718394; DOI=10.1139/w03-014;
RA   Murata M., Ohno S., Kumano M., Yamane K., Ohki R.;
RT   "Multidrug resistant phenotype of Bacillus subtilis spontaneous mutants
RT   isolated in the presence of puromycin and lincomycin.";
RL   Can. J. Microbiol. 49:71-77(2003).
RN   [4]
RP   FUNCTION.
RX   PubMed=15317768; DOI=10.1128/jb.186.17.5640-5648.2004;
RA   Yoshida K., Ohki Y.-H., Murata M., Kinehara M., Matsuoka H., Satomura T.,
RA   Ohki R., Kumano M., Yamane K., Fujita Y.;
RT   "Bacillus subtilis LmrA is a repressor of the lmrAB and yxaGH operons:
RT   identification of its binding site and functional analysis of lmrB and
RT   yxaGH.";
RL   J. Bacteriol. 186:5640-5648(2004).
RN   [5]
RP   REVIEW, AND GENE FAMILY.
RX   PubMed=15944459; DOI=10.1128/mmbr.69.2.326-356.2005;
RA   Ramos J.L., Martinez-Bueno M., Molina-Henares A.J., Teran W., Watanabe K.,
RA   Zhang X., Gallegos M.T., Brennan R., Tobes R.;
RT   "The TetR family of transcriptional repressors.";
RL   Microbiol. Mol. Biol. Rev. 69:326-356(2005).
RN   [6]
RP   FUNCTION.
RX   PubMed=17483215; DOI=10.1128/jb.00079-07;
RA   Hirooka K., Kunikane S., Matsuoka H., Yoshida K., Kumamoto K., Tojo S.,
RA   Fujita Y.;
RT   "Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and
RT   yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and
RT   YxaF, in response to flavonoids.";
RL   J. Bacteriol. 189:5170-5182(2007).
CC   -!- FUNCTION: Acts as repressor of the lincomycin-resistance (lmrAB) and
CC       yxaGH operons. {ECO:0000269|PubMed:12718394,
CC       ECO:0000269|PubMed:15317768, ECO:0000269|PubMed:17483215}.
DR   EMBL; AB000617; BAA22229.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12062.1; -; Genomic_DNA.
DR   PIR; D69652; D69652.
DR   RefSeq; NP_388150.1; NC_000964.3.
DR   RefSeq; WP_003246449.1; NZ_JNCM01000030.1.
DR   SMR; O34619; -.
DR   STRING; 224308.BSU02680; -.
DR   PaxDb; O34619; -.
DR   PRIDE; O34619; -.
DR   EnsemblBacteria; CAB12062; CAB12062; BSU02680.
DR   GeneID; 938385; -.
DR   KEGG; bsu:BSU02680; -.
DR   PATRIC; fig|224308.179.peg.278; -.
DR   eggNOG; ENOG4105J7D; Bacteria.
DR   eggNOG; ENOG4111TWN; LUCA.
DR   HOGENOM; HOG000161263; -.
DR   InParanoid; O34619; -.
DR   KO; K18939; -.
DR   OMA; EIDGWFE; -.
DR   PhylomeDB; O34619; -.
DR   BioCyc; BSUB:BSU02680-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
DR   PRODOM; O34619.
DR   SWISS-2DPAGE; O34619.
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..188
FT                   /note="HTH-type transcriptional regulator LmrA"
FT                   /id="PRO_0000360709"
FT   DOMAIN          4..64
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        27..46
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   188 AA;  20663 MW;  2FE6827325231A5F CRC64;
     MSYGDSREKI LSAATRLFQL QGYYGTGLNQ IIKESGAPKG SLYYHFPGGK EQLAIEAVNE
     MKEYIRQKIA DCMEACTDPA EGIQAFLKEL SCQFSCTEDI EGLPVGLLAA ETSLKSEPLR
     EACHEAYKEW ASVYEEKLRQ TGCSESRAKE ASTVVNAMIE GGILLSLTAK NSTPLLHISS
     CIPDLLKR
//

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