(data stored in ACNUC7421 zone)

SWISSPROT: NATR_BACSU

ID   NATR_BACSU              Reviewed;         233 AA.
AC   P70955;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   11-DEC-2019, entry version 123.
DE   RecName: Full=Transcriptional regulatory protein NatR {ECO:0000305};
GN   Name=natR {ECO:0000303|PubMed:17322186};
GN   Synonyms=yccH {ECO:0000312|EMBL:BAA22235.1};
GN   OrderedLocusNames=BSU02740 {ECO:0000312|EMBL:CAB12068.1};
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BD99;
RX   PubMed=9106203; DOI=10.1046/j.1365-2958.1997.2951656.x;
RA   Cheng J., Guffanti A.A., Krulwich T.A.;
RT   "A two-gene ABC-type transport system that extrudes Na+ in Bacillus
RT   subtilis is induced by ethanol or protonophore.";
RL   Mol. Microbiol. 23:1107-1120(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9274031; DOI=10.1099/00221287-143-8-2775;
RA   Kumano M., Tamakoshi A., Yamane K.;
RT   "A 32 kb nucleotide sequence from the region of the lincomycin-resistance
RT   gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and
RT   identification of the site of the lin-2 mutation.";
RL   Microbiology 143:2775-2782(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   FUNCTION.
RX   PubMed=11717295; DOI=10.1128/jb.183.24.7365-7370.2001;
RA   Kobayashi K., Ogura M., Yamaguchi H., Yoshida K., Ogasawara N., Tanaka T.,
RA   Fujita Y.;
RT   "Comprehensive DNA microarray analysis of Bacillus subtilis two-component
RT   regulatory systems.";
RL   J. Bacteriol. 183:7365-7370(2001).
RN   [5]
RP   FUNCTION, AND DNA-BINDING.
RC   STRAIN=168;
RX   PubMed=17322186; DOI=10.1099/mic.0.2006/003673-0;
RA   Ogura M., Tsukahara K., Hayashi K., Tanaka T.;
RT   "The Bacillus subtilis NatK-NatR two-component system regulates expression
RT   of the natAB operon encoding an ABC transporter for sodium ion extrusion.";
RL   Microbiology 153:667-675(2007).
CC   -!- FUNCTION: Member of the two-component regulatory system NatK/NatR that
CC       positively regulates the expression of the natAB operon. Acts by
CC       binding directly to the promoter of natAB.
CC       {ECO:0000269|PubMed:11717295, ECO:0000269|PubMed:17322186}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by NatK. {ECO:0000305}.
DR   EMBL; U30873; AAB53021.1; -; Genomic_DNA.
DR   EMBL; AB000617; BAA22235.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12068.1; -; Genomic_DNA.
DR   PIR; A69755; A69755.
DR   RefSeq; NP_388156.1; NC_000964.3.
DR   RefSeq; WP_003234759.1; NZ_JNCM01000030.1.
DR   STRING; 224308.BSU02740; -.
DR   PaxDb; P70955; -.
DR   PRIDE; P70955; -.
DR   EnsemblBacteria; CAB12068; CAB12068; BSU02740.
DR   GeneID; 938379; -.
DR   KEGG; bsu:BSU02740; -.
DR   PATRIC; fig|224308.179.peg.284; -.
DR   eggNOG; ENOG4107Y7X; Bacteria.
DR   eggNOG; COG3279; LUCA.
DR   HOGENOM; HOG000259011; -.
DR   InParanoid; P70955; -.
DR   KO; K11641; -.
DR   OMA; VARQYAH; -.
DR   PhylomeDB; P70955; -.
DR   BioCyc; BSUB:BSU02740-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00156; REC; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P70955.
DR   SWISS-2DPAGE; P70955.
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..233
FT                   /note="Transcriptional regulatory protein NatR"
FT                   /id="PRO_0000081392"
FT   DOMAIN          3..117
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          129..233
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   233 AA;  26969 MW;  1A6B4C9B5C08C67F CRC64;
     MVKVGLVDDY RVDLEKLEAI VSRMQDVEIV FSTDSAKEAY RRVKNGDIDL LLADIEMPHM
     SGYELADLIK SHSLDVDVIF VTGHGGYAVH AFDLNVHDYI MKPYYADRLA ASFDRYLKKK
     TETSLNGRIL IKQKSEMHVL QKKDIIFAER TGRSTTIVTT AEEVQTYQTL NDIKGDLPEK
     DFLRSHRSFI INIHYIKHFS AYTKHSFTVS FEGTSKKAMI TKQQLDYFQN YYF
//

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