(data stored in ACNUC7421 zone)

SWISSPROT: LCTP_BACSU

ID   LCTP_BACSU              Reviewed;         541 AA.
AC   P55910; O31470; O32395;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 3.
DT   11-DEC-2019, entry version 116.
DE   RecName: Full=L-lactate permease;
GN   Name=lctP; Synonyms=ycgC; OrderedLocusNames=BSU03060;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / VKM B-501;
RA   Murata M., Ohki R.;
RT   "Cloning and sequencing of the lct operon from Bacillus subtilis.";
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA   Yamane K., Kumano M., Kurita K.;
RT   "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT   determination of the sequence of a 146 kb segment and identification of 113
RT   genes.";
RL   Microbiology 142:3047-3056(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   SEQUENCE REVISION TO 262; 294; 379; 431; 520 AND 535.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [5]
RP   REGULATION.
RX   PubMed=10809684; DOI=10.1128/jb.182.11.3072-3080.2000;
RA   Cruz Ramos H., Hoffmann T., Marino M., Nedjari H., Presecan-Siedel E.,
RA   Dreesen O., Glaser P., Jahn D.;
RT   "Fermentative metabolism of Bacillus subtilis: physiology and regulation of
RT   gene expression.";
RL   J. Bacteriol. 182:3072-3080(2000).
CC   -!- FUNCTION: May play a role in L-lactate transport.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Strongly induced under anaerobic conditions. Activated by
CC       ResDE, Fnr and ArfM.
CC   -!- SIMILARITY: Belongs to the lactate permease family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA08940.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAA21776.1; Type=Frameshift; Evidence={ECO:0000305};
DR   EMBL; D50097; BAA21776.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; D50453; BAA08940.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL009126; CAB12100.2; -; Genomic_DNA.
DR   PIR; F69649; F69649.
DR   RefSeq; NP_388188.2; NC_000964.3.
DR   RefSeq; WP_003246465.1; NZ_JNCM01000030.1.
DR   STRING; 224308.BSU03060; -.
DR   PaxDb; P55910; -.
DR   PRIDE; P55910; -.
DR   EnsemblBacteria; CAB12100; CAB12100; BSU03060.
DR   GeneID; 938353; -.
DR   KEGG; bsu:BSU03060; -.
DR   PATRIC; fig|224308.179.peg.320; -.
DR   eggNOG; COG1620; LUCA.
DR   HOGENOM; HOG000253321; -.
DR   InParanoid; P55910; -.
DR   KO; K03303; -.
DR   OMA; VIVLWIQ; -.
DR   PhylomeDB; P55910; -.
DR   BioCyc; BSUB:BSU03060-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003; PTHR30003; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
DR   TIGRFAMs; TIGR00795; lctP; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P55910.
DR   SWISS-2DPAGE; P55910.
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..541
FT                   /note="L-lactate permease"
FT                   /id="PRO_0000210373"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        519..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        262
FT                   /note="L -> F (in Ref. 2; BAA08940)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        294
FT                   /note="K -> R (in Ref. 2; BAA08940)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        379
FT                   /note="F -> V (in Ref. 2; BAA08940)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        431
FT                   /note="K -> R (in Ref. 2; BAA08940)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        520
FT                   /note="A -> P (in Ref. 2; BAA08940)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        535
FT                   /note="I -> T (in Ref. 2; BAA08940)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   541 AA;  57604 MW;  4BEC73739F76E3BD CRC64;
     MWEQLYDPFG NEYVSALVAL TPILFFLLAL TVLKMKGILA AFLTLAVSFF VSVWAFHMPV
     EKAISSVLLG IGSGLWPIGY IVLMAVWLYK IAVKTGKFTI IRSSIAGISP DQRLQLLLIG
     FCFNAFLEGA AGFGVPIAIS AALLVELGFK PLKAAALCLI ANAASGAFGA IGIPVITGAQ
     IGDLSALELS RTLMWTLPMI SFLIPFLLVF LLDRMKGIKQ TWPALLVVSG GYTAVQTLTM
     AVLGPELANI LAALFSMGGL ALFLRKWQPK EIYREEGAGD AGEKKAYRAA DIAKAWSPFY
     ILTAAITIWS LPAFKALFQE GGLLYQSTLL FKMPFLHQQI MKMPPIAPSA MPLDAVFKVD
     LLSATGTAIL AAVIVTGLFS KKFSSRDAFA SLKETGKELW VPIMTICFVM GFANLANFAG
     LSSSIGLALA KTGDLFPFVS PVLGWIGVFI TGSVVSNNAL FGHLQVVTGA QIGAGSDLLL
     AANTAGGVMA KLVSPQSIAI AAAAVGQTGK ESKLFKRTVA YSLILLLIIC IWTFILARLG
     V
//

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