(data stored in SCRATCH zone)

SWISSPROT: HXLR_BACSU

ID   HXLR_BACSU              Reviewed;         120 AA.
AC   P42406; O31478;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 3.
DT   11-DEC-2019, entry version 114.
DE   RecName: Full=HTH-type transcriptional activator HxlR;
GN   Name=hxlR; OrderedLocusNames=BSU03470;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7704255; DOI=10.1099/13500872-141-2-277;
RA   Fujishima Y., Yamane K.;
RT   "A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of
RT   srfAA of the Bacillus subtilis chromosome.";
RL   Microbiology 141:277-279(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA   Yamane K., Kumano M., Kurita K.;
RT   "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT   determination of the sequence of a 146 kb segment and identification of 113
RT   genes.";
RL   Microbiology 142:3047-3056(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   SEQUENCE REVISION TO 62.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 111-120.
RX   PubMed=1715856; DOI=10.1128/jb.173.17.5487-5493.1991;
RA   Nakano M.M., Xia L., Zuber P.;
RT   "Transcription initiation region of the srfA operon, which is controlled by
RT   the comP-comA signal transduction system in Bacillus subtilis.";
RL   J. Bacteriol. 173:5487-5493(1991).
RN   [6]
RP   CHARACTERIZATION.
RC   STRAIN=168;
RX   PubMed=10572115;
RA   Yasueda H., Kawahara Y., Sugimoto S.;
RT   "Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose
RT   monophosphate pathway used by methylotrophs, and yckH is required for their
RT   expression.";
RL   J. Bacteriol. 181:7154-7160(1999).
CC   -!- FUNCTION: Positive regulator of hxlAB expression.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA06435.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA08981.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; D30762; BAA06435.1; ALT_INIT; Genomic_DNA.
DR   EMBL; D50453; BAA08981.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL009126; CAB12141.2; -; Genomic_DNA.
DR   EMBL; M64702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B69761; B69761.
DR   RefSeq; NP_388229.2; NC_000964.3.
DR   RefSeq; WP_003246265.1; NZ_JNCM01000030.1.
DR   SMR; P42406; -.
DR   STRING; 224308.BSU03470; -.
DR   PaxDb; P42406; -.
DR   PRIDE; P42406; -.
DR   DNASU; 938311; -.
DR   EnsemblBacteria; CAB12141; CAB12141; BSU03470.
DR   GeneID; 938311; -.
DR   KEGG; bsu:BSU03470; -.
DR   PATRIC; fig|224308.179.peg.364; -.
DR   eggNOG; ENOG4105KVH; Bacteria.
DR   eggNOG; COG1733; LUCA.
DR   HOGENOM; HOG000293547; -.
DR   InParanoid; P42406; -.
DR   OMA; WKAVILI; -.
DR   PhylomeDB; P42406; -.
DR   BioCyc; BSUB:BSU03470-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR002577; HTH_HxlR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01638; HxlR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51118; HTH_HXLR; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P42406.
DR   SWISS-2DPAGE; P42406.
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..120
FT                   /note="HTH-type transcriptional activator HxlR"
FT                   /id="PRO_0000148879"
FT   DOMAIN          11..110
FT                   /note="HTH hxlR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00435"
FT   CONFLICT        62
FT                   /note="L -> R (in Ref. 1; BAA06435 and 2; BAA08981)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   120 AA;  14104 MW;  C53CCB6E84BAE8AF CRC64;
     MSRMDDKRFN CEKELTLAVI GGKWKMLILW HLGKEGTKRF NELKTLIPDI TQKILVNQLR
     ELEQDMIVHR EVYPVVPPKV EYSLTPHGES LMPILEAMYE WGKGYMELID IDKNVMKESL
//

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