(data stored in ACNUC7421 zone)

SWISSPROT: SRFAB_BACSU

ID   SRFAB_BACSU             Reviewed;        3583 AA.
AC   Q04747;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 3.
DT   11-DEC-2019, entry version 150.
DE   RecName: Full=Surfactin synthase subunit 2;
GN   Name=srfAB; Synonyms=comL, srfA2; OrderedLocusNames=BSU03490;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3073.
RC   STRAIN=168;
RX   PubMed=8441623; DOI=10.1093/nar/21.1.93;
RA   Fuma S., Fujishima Y., Corbell N., D'Souza C., Nakano M.M., Zuber P.,
RA   Yamane K.;
RT   "Nucleotide sequence of 5' portion of srfA that contains the region
RT   required for competence establishment in Bacillus subtilis.";
RL   Nucleic Acids Res. 21:93-97(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8355609; DOI=10.1111/j.1365-2958.1993.tb01629.x;
RA   Cosmina P., Rodriguez F., de Ferra F., Grandi G., Perego M., Venema G.,
RA   van Sinderen D.;
RT   "Sequence and analysis of the genetic locus responsible for surfactin
RT   synthesis in Bacillus subtilis.";
RL   Mol. Microbiol. 8:821-831(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA   Yamane K., Kumano M., Kurita K.;
RT   "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT   determination of the sequence of a 146 kb segment and identification of 113
RT   genes.";
RL   Microbiology 142:3047-3056(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [5]
RP   SEQUENCE REVISION.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 507-795.
RC   STRAIN=ATCC 21332 / IAM 1213;
RX   PubMed=1601288; DOI=10.1016/0378-1097(92)90508-l;
RA   Borchert S., Patil S.S., Marahiel M.A.;
RT   "Identification of putative multifunctional peptide synthetase genes using
RT   highly conserved oligonucleotide sequences derived from known
RT   synthetases.";
RL   FEMS Microbiol. Lett. 71:175-180(1992).
RN   [7]
RP   PHOSPHOPANTETHEINYLATION [LARGE SCALE ANALYSIS] AT SER-999 AND SER-2040,
RP   AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=168;
RX   PubMed=17218307; DOI=10.1074/mcp.m600464-mcp200;
RA   Macek B., Mijakovic I., Olsen J.V., Gnad F., Kumar C., Jensen P.R.,
RA   Mann M.;
RT   "The serine/threonine/tyrosine phosphoproteome of the model bacterium
RT   Bacillus subtilis.";
RL   Mol. Cell. Proteomics 6:697-707(2007).
CC   -!- FUNCTION: This protein is a multifunctional enzyme able to activate and
CC       polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for
CC       these AA consist of individual domains.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC       Note=Binds 3 phosphopantetheines covalently.;
CC   -!- PATHWAY: Antibiotic biosynthesis; surfactin biosynthesis.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The phosphoserine observed at Ser-999 and Ser-2040 in
CC       PubMed:17218307 may result from the secondary neutral loss of
CC       pantetheine from the phosphodiester linked cofactor. {ECO:0000305}.
DR   EMBL; D13262; BAA02523.1; -; Genomic_DNA.
DR   EMBL; X70356; CAA49817.1; -; Genomic_DNA.
DR   EMBL; D50453; BAA08983.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12143.2; -; Genomic_DNA.
DR   EMBL; X65835; CAA46678.1; -; Genomic_DNA.
DR   PIR; I40486; I40486.
DR   RefSeq; NP_388231.2; NC_000964.3.
DR   RefSeq; WP_010886403.1; NZ_CP019663.1.
DR   SMR; Q04747; -.
DR   IntAct; Q04747; 3.
DR   MINT; Q04747; -.
DR   STRING; 224308.BSU03490; -.
DR   jPOST; Q04747; -.
DR   PaxDb; Q04747; -.
DR   PRIDE; Q04747; -.
DR   EnsemblBacteria; CAB12143; CAB12143; BSU03490.
DR   GeneID; 938303; -.
DR   KEGG; bsu:BSU03490; -.
DR   PATRIC; fig|224308.179.peg.367; -.
DR   HOGENOM; HOG000229991; -.
DR   InParanoid; Q04747; -.
DR   KO; K15655; -.
DR   OMA; FNMQNME; -.
DR   PhylomeDB; Q04747; -.
DR   BioCyc; BSUB:BSU03490-MONOMER; -.
DR   UniPathway; UPA00181; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1200.10; -; 3.
DR   Gene3D; 3.30.559.10; -; 4.
DR   Gene3D; 3.40.50.12780; -; 3.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; AMP-dep_Synthh-like_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   SUPFAM; SSF47336; SSF47336; 3.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 3.
DR   TIGRFAMs; TIGR01720; NRPS-para261; 1.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   1: Evidence at protein level;
DR   PRODOM; Q04747.
DR   SWISS-2DPAGE; Q04747.
KW   Antibiotic biosynthesis; Ligase; Multifunctional enzyme;
KW   Phosphopantetheine; Phosphoprotein; Reference proteome; Repeat;
KW   Sporulation.
FT   CHAIN           1..3583
FT                   /note="Surfactin synthase subunit 2"
FT                   /id="PRO_0000193100"
FT   DOMAIN          965..1039
FT                   /note="Carrier 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          2005..2080
FT                   /note="Carrier 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          3034..3108
FT                   /note="Carrier 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   REGION          ?..1040
FT                   /note="Domain 1 (valine-activating)"
FT   REGION          ?..2091
FT                   /note="Domain 2 (aspartate-activating)"
FT   REGION          ?..3110
FT                   /note="Domain 3 (D-leucine-activating)"
FT   MOD_RES         999
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT                   ECO:0000269|PubMed:17218307"
FT   MOD_RES         2040
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258,
FT                   ECO:0000269|PubMed:17218307"
FT   MOD_RES         3069
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   CONFLICT        33
FT                   /note="F -> S (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        42
FT                   /note="G -> A (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        110
FT                   /note="D -> Q (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        113
FT                   /note="R -> A (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        115
FT                   /note="G -> A (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        139
FT                   /note="V -> A (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        259
FT                   /note="W -> L (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        309
FT                   /note="A -> R (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        478..480
FT                   /note="TPA -> SRP (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        507..513
FT                   /note="LVEHGLQ -> ACRTRPS (in Ref. 6; CAA46678)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        595
FT                   /note="Missing (in Ref. 6; CAA46678)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        648
FT                   /note="R -> A (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        680..682
FT                   /note="ETL -> RHV (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        694..698
FT                   /note="EQSIT -> DKRIS (in Ref. 6; CAA46678)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        788
FT                   /note="M -> L (in Ref. 6; CAA46678)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        939..940
FT                   /note="PL -> LV (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1038
FT                   /note="N -> I (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1133
FT                   /note="Q -> H (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1310
FT                   /note="V -> C (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1333
FT                   /note="V -> G (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1384
FT                   /note="P -> R (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1582
FT                   /note="E -> G (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1677
FT                   /note="E -> KRRADG (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1695
FT                   /note="S -> C (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1750
FT                   /note="K -> F (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1782
FT                   /note="T -> S (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1796..1817
FT                   /note="GAIAGRVDLYEPDAFAKRPTIG -> APSPGGLICMSRCICETPDNR (in
FT                   Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1910..1911
FT                   /note="PK -> LG (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2070
FT                   /note="R -> C (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2074
FT                   /note="A -> V (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2134..2141
FT                   /note="SRLRDSLN -> WPARLTP (in Ref. 2; CAA49817 and 3;
FT                   BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2134..2135
FT                   /note="SR -> WP (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2441
FT                   /note="Q -> E (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2481..2485
FT                   /note="ATDLF -> RQICS (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2542..2562
FT                   /note="TVHQLFEETVQRHKDRPAVTY -> DGCISYSKRLSSATKTARLSHT (in
FT                   Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2604..2611
FT                   /note="MSAAVLGV -> KCPPRCSAS (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2640..2641
FT                   /note="KL -> NV (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2709
FT                   /note="H -> D (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2719
FT                   /note="H -> D (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2872..2877
FT                   /note="GELCVA -> RALRG (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2895..2896
FT                   /note="RF -> L (in Ref. 1; BAA02523)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2954..2956
FT                   /note="QDA -> EDR (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2960
FT                   /note="A -> R (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3236..3237
FT                   /note="EQ -> AE (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3533
FT                   /note="Q -> E (in Ref. 2; CAA49817 and 3; BAA08983)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   3583 AA;  400944 MW;  A257AC7643C4C64C CRC64;
     MSKKSIQKVY ALTPMQEGML YHAMLDPHSS SYFTQLELGI HGAFDLEIFE KSVNELIRSY
     DILRTVFVHQ QLQKPRQVVL AERKTKVHYE DISHADENRQ KEHIERYKQD VQRQGFNLAK
     DILFKVAVFR LAADQLYLVW SNHHIMMDGW SMGVLMKSLF QNYEALRAGR TPANGQGKPY
     SDYIKWLGKQ DNEEAESYWS ERLAGFEQPS VLPGRLPVKK DEYVNKEYSF TWDETLVARI
     QQTANLHQVT GPNLFQAVWG IVLSKYNFTD DVIFGTVVSG RPSEINGIET MAGLFINTIP
     VRVKVERDAA FADIFTAVQQ HAVEAERYDY VPLYEIQKRS ALDGNLLNHL VAFENYPLDQ
     ELENGSMEDR LGFSIKVESA FEQTSFDFNL IVYPGKTWTV KIKYNGAAFD SAFIERTAEH
     LTRMMEAAVD QPAAFVREYG LVGDEEQRQI VEVFNSTKAE LPEGMAVHQV FEEQAKRTPA
     STAVVYEGTK LTYRELNAAA NRLARKLVEH GLQKGETAAI MNDRSVETVV GMLAVLKAGA
     AYVPLDPALP GDRLRFMAED SSVRMVLIGN SYTGQAHQLQ VPVLTLDIGF EESEAADNLN
     LPSAPSDLAY IMYTSGSTGK PKGVMIEHKS ILRLVKNAGY VPVTEEDRMA QTGAVSFDAG
     TFEVFGALLN GAALYPVKKE TLLDAKQFAA FLREQSITTM WLTSPLFNQL AAKDAGMFGT
     LRHLIIGGDA LVPHIVSKVK QASPSLSLWN GYGPTENTTF STSFLIDREY GGSIPIGKPI
     GNSTAYIMDE QQCLQPIGAP GELCVGGIGV ARGYVNLPEL TEKQFLEDPF RPGERIYRTG
     DLARWLPDGN IEFLGRIDNQ VKVRGFRIEL GEIETKLNMA EHVTEAAVII RKNKADENEI
     CAYFTADREV AVSELRKTLS QSLPDYMVPA HLIQMDSLPL TPNGKINKKE LPAPQSEAVQ
     PEYAAPKTES EKKLAEIWEG ILGVKAGVTD NFFMIGGHSL KAMMMTAKIQ EHFHKEVPIK
     VLFEKPTIQE LALYLEENES KEEQTFEPIR QASYQQHYPV SPAQRRMYIL NQLGQANTSY
     NVPAVLLLEG EVDKDRLENA IQQLINRHEI LRTSFDMIDG EVVQTVHKNI SFQLEAAKGR
     EEDAEEIIKA FVQPFELNRA PLVRSKLVQL EEKRHLLLID MHHIITDGSS TGILIGDLAK
     IYQGADLELP QIHYKDYAVW HKEQTNYQKD EEYWLDVFKG ELPILDLPAD FERPAERSFA
     GERVMFGLDK QITAQIKSLM AETDTTMYMF LLAAFNVLLS KYASQDDIIV GSPTAGRTHP
     DLQGVPGMFV NTVALRTAPA GDKTFAQFLE EVKTASLQAF EHQSYPLEEL IEKLPLTRDT
     SRSPLFSVMF NMQNMEIPSL RLGDLKISSY SMLHHVAKFD LSLEAVEREE DIGLSFDYAT
     ALFKDETIRR WSRHFVNIIK AAAANPNVRL SDVDLLSSAE TAALLEERHM TQITEATFAA
     LFEKQAQQTP DHSAVKAGGN LLTYRELDEQ ANQLAHHLRA QGAGNEDIVA IVMDRSAEVM
     VSILGVMKAG AAFLPIDPDT PEERIRYSLE DSGAKFAVVN ERNMTAIGQY EGIIVSLDDG
     KWRNESKERP SSISGSRNLA YVIYTSGTTG KPKGVQIEHR NLTNYVSWFS EEAGLTENDK
     TVLLSSYAFD LGYTSMFPVL LGGGELHIVQ KETYTAPDEI AHYIKEHGIT YIKLTPSLFH
     TIVNTASFAK DANFESLRLI VLGGEKIIPT DVIAFRKMYG HTEFINHYGP TEATIGAIAG
     RVDLYEPDAF AKRPTIGRPI ANAGALVLNE ALKLVPPGAS GQLYITGQGL ARGYLNRPQL
     TAERFVENPY SPGSLMYKTG DVVRRLSDGT LAFIGRADDQ VKIRGYRIEP KEIETVMLSL
     SGIQEAVVLA VSEGGLQELC AYYTSDQDIE KAELRYQLSL TLPSHMIPAF FVQVDAIPLT
     ANGKTDRNAL PKPNAAQSGG KALAAPETAL EESLCRIWQK TLGIEAIGID DNFFDLGGHS
     LKGMMLIANI QAELEKSVPL KALFEQPTVR QLAAYMEASA VSGGHQVLKP ADKQDMYPLS
     SAQKRMYVLN QLDRQTISYN MPSVLLMEGE LDISRLRDSL NQLVNRHESL RTSFMEANGE
     PVQRIIEKAE VDLHVFEAKE DEADQKIKEF IRPFDLNDAP LIRAALLRIE AKKHLLLLDM
     HHIIADGVSR GIFVKELALL YKGEQLPEPT LHYKDFAVWQ NEAEQKERMK EHEAYWMSVL
     SGELPELDLP LDYARPPVQS FKGDTIRFRT GSETAKAVEK LLAETGTTLH MVLHAVFHVF
     LSKISGQRDI VIGSVTAGRT NADVQDMPGM FVNTLALRME AKEQQTFAEL LELAKQTNLS
     ALEHQEYPFE DLVNQLDLPR DMSRNPLFNV MVTTENPDKE QLTLQNLSIS PYEAHQGTSK
     FDLTLGGFTD ENGIGLQLEY ATDLFAKETA EKWSEYVLRL LKAVADNPNQ PLSSLLLVTE
     TEKQALLEAW KGKALPVPTD KTVHQLFEET VQRHKDRPAV TYNGQSWTYG ELNAKANRLA
     RILMDCGISP DDRVGVLTKP SLEMSAAVLG VLKAGAAFVP IDPDYPDQRI EYILQDSGAK
     LLLKQEGISV PDSYTGDVIL LDGSRTILSL PLDENDEGNP ETAVTAENLA YMIYTSGTTG
     QPKGVMVEHH ALVNLCFWHH DAFSMTAEDR SAKYAGFGFD ASIWEMFPTW TIGAELHVID
     EAIRLDIVRL NDYFETNGVT ITFLPTQLAE QFMELENTSL RVLLTGGDKL KRAVKKPYTL
     VNNYGPTENT VVATSAEIHP EEGSLSIGRA IANTRVYILG EGNQVQPEGV AGELCVAGRG
     LARGYLNRED ETAKRFVADP FVPGERMYRT GDLVKWVNGG IEYIGRIDQQ VKVRGYRIEL
     SEIEVQLAQL SEVQDAAVTA VKDKGGNTAI AAYVTPETAD IEALKSTLKE TLPDYMIPAF
     WVTLNELPVT ANGKVDRKAL PEPDIEAGSG EYKAPTTDME ELLAGIWQDV LGMSEVGVTD
     NFFSLGGDSI KGIQMASRLN QHGWKLEMKD LFQHPTIEEL TQYVERAEGK QADQGPVEGE
     VILTPIQRWF FEKNFTNKHH WNQSVMLHAK KGFDPERVEK TLQALIEHHD ALRMVYREEN
     GDIVQVYKPI GESKVSFEIV DLYGSDEEML RSQIKLLANK LQSSLDLRNG PLLKAEQYRT
     EAGDHLLIAV HHLVVDGVSW RILLEDFASG YMQAEKEESL VFPQKTNSFK DWAEELAAFS
     QSAHLLQQAE YWSQIAAEQV SPLPKDCETE QRIVKDTSSV LCELTAEDTK HLLTDVHQPY
     GTEINDILLS ALGLTMKEWT KGAKIGINLE GHGREDIIPN VNISRTVGWF TAQYPVVLDI
     SDADASAVIK TVKENLRRIP DKGVGYGILR YFTETAETKG FTPEISFNYL GQFDSEVKTD
     FFEPSAFDMG RQVSGESEAL YALSFSGMIR NGRFVLSCSY NEKEFERATV EEQMERFKEN
     LLMLIRHCTE KEDKEFTPSD FSAEDLEMDE MGDIFDMLEE NLK
//

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