(data stored in ACNUC7421 zone)

SWISSPROT: LIPC_BACSU

ID   LIPC_BACSU              Reviewed;         213 AA.
AC   P42969;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   11-DEC-2019, entry version 111.
DE   RecName: Full=Spore germination lipase LipC;
DE            EC=3.-.-.-;
GN   Name=lipC; Synonyms=ycsK; OrderedLocusNames=BSU04110;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8574415; DOI=10.1099/13500872-141-12-3241;
RA   Akagawa E., Kurita K., Sugawara T., Nakamura K., Kasahara Y., Ogasawara N.,
RA   Yamane K.;
RT   "Determination of a 17,484 bp nucleotide sequence around the 39 degrees
RT   region of the Bacillus subtilis chromosome and similarity analysis of the
RT   products of putative ORFs.";
RL   Microbiology 141:3241-3245(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA   Yamane K., Kumano M., Kurita K.;
RT   "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT   determination of the sequence of a 146 kb segment and identification of 113
RT   genes.";
RL   Microbiology 142:3047-3056(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND EXPRESSION.
RC   STRAIN=168;
RX   PubMed=17220230; DOI=10.1128/jb.01527-06;
RA   Masayama A., Kuwana R., Takamatsu H., Hemmi H., Yoshimura T., Watabe K.,
RA   Moriyama R.;
RT   "A novel lipolytic enzyme, YcsK (LipC), located in the spore coat of
RT   Bacillus subtilis, is involved in spore germination.";
RL   J. Bacteriol. 189:2369-2375(2007).
CC   -!- FUNCTION: Lipase involved in spore germination.
CC       {ECO:0000269|PubMed:17220230}.
CC   -!- SUBCELLULAR LOCATION: Spore wall, spore coat
CC       {ECO:0000269|PubMed:17220230}.
CC   -!- DEVELOPMENTAL STAGE: Transcribed from stage t4 of sporulation.
CC       Expressed in the mother cell compartment at the late stage of
CC       sporulation and localizes around forespores in a CotE, SafA and SpoIVD-
CC       dependent manner.
CC   -!- INDUCTION: Transcribed under the control of SigK and positively
CC       regulated by GerE.
CC   -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC       {ECO:0000305}.
DR   EMBL; D38161; BAA07363.1; -; Genomic_DNA.
DR   EMBL; D50453; BAA09041.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12218.1; -; Genomic_DNA.
DR   PIR; I39900; I39900.
DR   RefSeq; NP_388292.1; NC_000964.3.
DR   RefSeq; WP_003234415.1; NZ_JNCM01000031.1.
DR   STRING; 224308.BSU04110; -.
DR   PaxDb; P42969; -.
DR   PRIDE; P42969; -.
DR   EnsemblBacteria; CAB12218; CAB12218; BSU04110.
DR   GeneID; 938249; -.
DR   KEGG; bsu:BSU04110; -.
DR   PATRIC; fig|224308.179.peg.437; -.
DR   eggNOG; ENOG4105XJB; Bacteria.
DR   eggNOG; COG2755; LUCA.
DR   HOGENOM; HOG000008743; -.
DR   InParanoid; P42969; -.
DR   OMA; LYNPFPG; -.
DR   PhylomeDB; P42969; -.
DR   BioCyc; BSUB:BSU04110-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0031160; C:spore wall; IEA:UniProtKB-SubCell.
DR   GO; GO:0004622; F:lysophospholipase activity; IBA:GO_Central.
DR   GO; GO:0016042; P:lipid catabolic process; IDA:CACAO.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1110; -; 1.
DR   InterPro; IPR013830; SGNH_hydro.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   Pfam; PF13472; Lipase_GDSL_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P42969.
DR   SWISS-2DPAGE; P42969.
KW   Hydrolase; Reference proteome; Sporulation.
FT   CHAIN           1..213
FT                   /note="Spore germination lipase LipC"
FT                   /id="PRO_0000049481"
FT   ACT_SITE        11
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        186
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        189
FT                   /evidence="ECO:0000250"
FT   BINDING         50
FT                   /note="Substrate; via amide nitrogen"
FT                   /evidence="ECO:0000250"
FT   BINDING         82
FT                   /note="Substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   213 AA;  23606 MW;  8A0E5C840D0F9A8E CRC64;
     MVLRYTALGD SLTTGRGSGL FSPGFVQRFG DMMEADLKTR TAINIFARSG LNTEEILGLL
     SYPYVQKCIR DADMITITGC GNDLIDSVLA YQTSKDETIF SRVSAHCHEN FEKMIAKVAE
     IKGENPSPYA IRVFNLYNPF PEIDIAGKWI TSFNSHLETL ASAPHVKIAD AYSIFKGKEQ
     EYLSFDGVHP NSKGYQAMAE AVHKLGYKEL SVS
//

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