(data stored in ACNUC7421 zone)

SWISSPROT: MNTH_BACSU

ID   MNTH_BACSU              Reviewed;         425 AA.
AC   P96593;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   11-DEC-2019, entry version 122.
DE   RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN   Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; Synonyms=ydaR;
GN   OrderedLocusNames=BSU04360;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT   "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT   subtilis genome.";
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION IN MANGANESE UPTAKE, INDUCTION, AND GENE NAME.
RC   STRAIN=168;
RX   PubMed=10760146; DOI=10.1046/j.1365-2958.2000.01811.x;
RA   Que Q., Helmann J.D.;
RT   "Manganese homeostasis in Bacillus subtilis is regulated by MntR, a
RT   bifunctional regulator related to the diphtheria toxin repressor family of
RT   proteins.";
RL   Mol. Microbiol. 35:1454-1468(2000).
CC   -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC       Involved in manganese uptake. Can probably also transport cadmium,
CC       cobalt, copper and zinc, but not iron. May be the predominant
CC       transporter of manganese during logarithmic phase growth.
CC       {ECO:0000255|HAMAP-Rule:MF_00221, ECO:0000269|PubMed:10760146}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Repressed by MntR in the presence of manganese.
CC       {ECO:0000269|PubMed:10760146}.
CC   -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
DR   EMBL; AB001488; BAA19273.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12243.1; -; Genomic_DNA.
DR   PIR; A69770; A69770.
DR   RefSeq; NP_388317.1; NC_000964.3.
DR   RefSeq; WP_003234364.1; NZ_JNCM01000031.1.
DR   SMR; P96593; -.
DR   IntAct; P96593; 4.
DR   STRING; 224308.BSU04360; -.
DR   TCDB; 2.A.55.3.3; the metal ion (mn(2+)-iron) transporter (nramp) family.
DR   PaxDb; P96593; -.
DR   PRIDE; P96593; -.
DR   EnsemblBacteria; CAB12243; CAB12243; BSU04360.
DR   GeneID; 938241; -.
DR   KEGG; bsu:BSU04360; -.
DR   PATRIC; fig|224308.179.peg.462; -.
DR   eggNOG; ENOG4105C56; Bacteria.
DR   eggNOG; COG1914; LUCA.
DR   HOGENOM; HOG000152205; -.
DR   InParanoid; P96593; -.
DR   KO; K03322; -.
DR   OMA; LIQYQSA; -.
DR   PhylomeDB; P96593; -.
DR   BioCyc; BSUB:BSU04360-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071281; P:cellular response to iron ion; IBA:GO_Central.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P96593.
DR   SWISS-2DPAGE; P96593.
KW   Cell membrane; Ion transport; Manganese; Membrane; Reference proteome;
KW   Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..425
FT                   /note="Divalent metal cation transporter MntH"
FT                   /id="PRO_0000212611"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        209..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ   SEQUENCE   425 AA;  45686 MW;  45F099720608FBA0 CRC64;
     MMNKDITAQS PRSKAVQDAL DGKIRGFRGL LPFLGPAFIA AIAYIDPGNF ATNISAGSKY
     GYMLLWVILF SNIMALLIQS LSAKLGIATG KNLPEVAREE FPKPVSIGLW IQGELVIIAT
     DLAEFIGAAL GLYLLFGIPM LEASIIAAIG SFAILELQRR GYRSLEAGIA GMLFVVVIAF
     ALQTFFAKPD AVSVMKGLFV PAFHGTDSVL LAAGILGATV MPHAIYLHSA LTQRRVVGKT
     DAERKKIFRF EFIDILIAML IAGAINASML IVAAALFFKN GLFVEDLDVA FQQFGHLVSP
     MSAALFGIGL LVAGLSSSSV GTLSGDVIMQ GFINYRIPLY VRRFITIIPP ILIIASGVNP
     TTALVLSQVV LSFGIAFALI PLIMFTSNKR IMGSLINAKW ITVVSWLIAV LIVALNVFLI
     VDTFR
//

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