(data stored in ACNUC7421 zone)

SWISSPROT: DCTB_BACSU

ID   DCTB_BACSU              Reviewed;         350 AA.
AC   P96600; Q797L6;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   11-DEC-2019, entry version 102.
DE   RecName: Full=C4-dicarboxylate-binding protein DctB;
DE   Flags: Precursor;
GN   Name=dctB; Synonyms=ydbE; OrderedLocusNames=BSU04440;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT   "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT   subtilis genome.";
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RX   PubMed=10708364; DOI=10.1099/00221287-146-2-263;
RA   Asai K., Baik S.-H., Kasahara Y., Moriya S., Ogasawara N.;
RT   "Regulation of the transport system for C4-dicarboxylic acids in Bacillus
RT   subtilis.";
RL   Microbiology 146:263-271(2000).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       uptake of C4-dicarboxylates. Responsible for growth on fumarate and
CC       succinate but not malate. Is not directly involved in C4-dicarboxylate
CC       uptake, but plays a sensory role in the DctS/DctR two-component system
CC       which regulates the expression of the dctA C4-dicarboxylate
CC       transporter. {ECO:0000269|PubMed:10708364}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 7 family.
CC       {ECO:0000305}.
DR   EMBL; AB001488; BAA19281.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12251.1; -; Genomic_DNA.
DR   PIR; H69770; H69770.
DR   RefSeq; NP_388325.1; NC_000964.3.
DR   RefSeq; WP_003234350.1; NZ_JNCM01000031.1.
DR   SMR; P96600; -.
DR   STRING; 224308.BSU04440; -.
DR   PaxDb; P96600; -.
DR   PRIDE; P96600; -.
DR   EnsemblBacteria; CAB12251; CAB12251; BSU04440.
DR   GeneID; 938226; -.
DR   KEGG; bsu:BSU04440; -.
DR   PATRIC; fig|224308.179.peg.470; -.
DR   eggNOG; ENOG4105DR6; Bacteria.
DR   eggNOG; COG1638; LUCA.
DR   HOGENOM; HOG000251308; -.
DR   InParanoid; P96600; -.
DR   OMA; FRIMPSE; -.
DR   PhylomeDB; P96600; -.
DR   BioCyc; BSUB:BSU04440-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.40.190.170; -; 1.
DR   InterPro; IPR004682; TRAP_DctP.
DR   InterPro; IPR018389; TRAP_DctP/TeaA.
DR   InterPro; IPR038404; TRAP_DctP_sf.
DR   PANTHER; PTHR33376; PTHR33376; 1.
DR   Pfam; PF03480; DctP; 1.
DR   PIRSF; PIRSF006470; DctB; 1.
DR   TIGRFAMs; TIGR00787; dctP; 1.
PE   3: Inferred from homology;
DR   PRODOM; P96600.
DR   SWISS-2DPAGE; P96600.
KW   Reference proteome; Secreted; Signal; Sugar transport; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..350
FT                   /note="C4-dicarboxylate-binding protein DctB"
FT                   /id="PRO_0000360643"
SQ   SEQUENCE   350 AA;  39862 MW;  25F40C93E20E0E24 CRC64;
     MKSLLACLAL MIAGIATALF IGFHDHTGNK KIVYDDDQEG LQDQIVFKFS HVVAENTPKG
     LAANKFADLV NEKSGGKIKI EVFPNGSLYS DIEEIEALQN GDVQFIAPST SKLGMLSPEW
     GVLDLPYAFT DYNAVKKGLN GSIGTQLFDS LKKNQLKGLA YWTNGFKQIT TNQGPVKTPD
     DLKGQDLRIM QSDVIEDQFK LLGATPHQES FNSTFQLLEN NVVDGEENTI SNIYSKKFYN
     VQDYLTISSH GYLGYAVMTD EHFWKAQTPE TRRILTEAMK ETTEWNETYA EQMNKEQLEE
     IKKNSAIHIY ELSDKEKQEW MKRLDPVYRQ YEPIFGRELI RELLELRKDS
//

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