(data stored in ACNUC1104 zone)

SWISSPROT: Q9FCK4_STRCO

ID   Q9FCK4_STRCO            Unreviewed;      1222 AA.
AC   Q9FCK4;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   08-MAY-2019, entry version 114.
DE   SubName: Full=Putative ATP-dependent DNA helicase {ECO:0000313|EMBL:CAC01314.1};
GN   OrderedLocusNames=SCO5184 {ECO:0000313|EMBL:CAC01314.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAC01314.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145
RC   {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.H., Kieser T., Larke L., Murphy L., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS01099290};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|SAAS:SAAS00709641}.
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DR   EMBL; AL939122; CAC01314.1; -; Genomic_DNA.
DR   RefSeq; NP_629332.1; NC_003888.3.
DR   RefSeq; WP_011030104.1; NC_003888.3.
DR   STRING; 100226.SCO5184; -.
DR   EnsemblBacteria; CAC01314; CAC01314; CAC01314.
DR   GeneID; 1100625; -.
DR   KEGG; sco:SCO5184; -.
DR   PATRIC; fig|100226.15.peg.5268; -.
DR   eggNOG; ENOG4106AQX; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   eggNOG; COG2887; LUCA.
DR   HOGENOM; HOG000247959; -.
DR   InParanoid; Q9FCK4; -.
DR   KO; K03657; -.
DR   OMA; SGHWWGP; -.
DR   PhylomeDB; Q9FCK4; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0000725; P:recombinational repair; IBA:GO_Central.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q9FCK4.
DR   SWISS-2DPAGE; Q9FCK4.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001973};
KW   DNA damage {ECO:0000256|SAAS:SAAS01099294};
KW   DNA repair {ECO:0000256|SAAS:SAAS01099287};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Exonuclease {ECO:0000256|SAAS:SAAS01033115};
KW   Helicase {ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:CAC01314.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062};
KW   Nuclease {ECO:0000256|SAAS:SAAS01033141};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT   DOMAIN       68    394       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   DOMAIN      395    714       UvrD-like helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51217}.
FT   COILED      265    285       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1222 AA;  131719 MW;  B2BEBF2DDDC58EBA CRC64;
     MWPDRSRPGP PEPPRRAAGV TRRTTRADLH FPPTREDIRH QLSVAAASLS DVPAHITDPE
     QLKELLGIPF TPEQTACIVA PPAPQVIVAG AGSGKTTVMA ARVVWLVGTG QVAPEQVLGL
     TFTNKAAGEL AERVRTALIR AGVTDPDVID PDHPPGEPAI STYHAFAGRL LTDHGLRLGL
     EPTSRLLADA TRYQLAARVL REAPGPYPAL TRSFADLVSD LLALDGELAE HLVRPEDLRA
     WDAGLLDTLD GVRLSNADLR KVPEAAAARR ELADLVIRYR AAKRRQDLLD FGDQIALSAQ
     LAGLPEVGRV LRDDYRVVLL DEYQDTSVAQ RILLAGLFGG GTGHPVTAVG DPCQAIYGWR
     GASVANLDDF PEHFAHADGR PAARQALSEN RRSGGRLLDL ANGLAEPLRA MHAGVEALRP
     APGAERDGMV RCALLSTHAE EIDWIADSVA HLVRTGKAPG EIAVLCRTAT DFAEIQGALV
     ARDVPVEVVG LSGLLHLPEV ADLVAVCEVL QDPGANASLV RLLSGPRWRV GPRDLALLGR
     RARLLVSHAR VEGDDDPDRR LAEAVEGVDP SEVISLADAL DTFLETPLDG TGDDDGLPFS
     ADARVRFARL ATELRELRRA LSDPLMDVLH RVLAVTGLEV ELSASPHALA ARRRETLSNF
     LDVAASFAAG DGEATLLAFL GFLRTAAQYE KGLDNALPGG ENTVKVLTAH KSKGLEWDVV
     AVPGLVTGTF PSGQGREKWT AQGKVLPHGL RGDAETLPDV ASWDARGLKA FHEAMKDHQH
     TEELRLGYVT FTRPRSLLLG SGHWWGPSQK KPRGPSDFLT ALYEHCAAGH GEIEVWADEP
     AEDEENPALH RATADEVWPL PLDDAALARR RSAAETVLAH LDGLAAREDG PPSAPATYED
     PDWPPPPEDD EGLPEEAEPD RAGDPAHWDS WTTERPAAAR EAATAPESPA APQAGPTVPH
     QAPPPEQPPG TAPVPAPARL TPEEARTVAS WDRDLDALTG ELLRARESVT EVPLPASLTA
     SQLLSLAADP DGFAQELARP MPRPPQPAAR RGTRFHAWVE ARFEPLTLPL LEPEELPGGD
     AEIADDHDLE FLKDAFERTE YARRTPFRVE APFQLSLAGR VVRGRIDAVY KEGDGDTATY
     EIVDWKTNRA ATADPLQLAL YRIAWAEQQH VPPASVTAAF LYVRTGEVVR PEGLPDRAAL
     EKLLLAEPVG DEPHDRGVRA GR
//

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